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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 18 Mar 2014.

Glypican 1

glypican-1, GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, Fibroblast Growth Factor 2, syndecan-4, V1a
Papers on glypican-1
Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity.
Haupt et al., Brisbane, Australia. In J Cell Biochem, 31 May 2014
We examined the expression profile of HSPG core protein syndecans (SDC1-4) and glypicans (GPC1-6) along with the enzymes that initiate or modify their glycosaminoglycan chains in human breast cancer (HBC) epithelial cells.
Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1.
Tarbell et al., United States. In Integr Biol (camb), 24 Apr 2014
We hypothesized that the glypican-1 (GPC1) HS core protein mediates flow-induced EC NO synthase (eNOS) activation because GPC1 is anchored to caveolae where eNOS resides.
Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells.
Suárez et al., New Haven, United States. In J Cell Sci, 15 Apr 2014
MicroRNA-149 (miR-149) is located within the first intron of the glypican-1 (GPC1) gene.
The role of glypicans in Hedgehog signaling.
Capurro et al., Canada. In Matrix Biol, 08 Feb 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
The effect of nutritional status and myogenic satellite cell age on turkey satellite cell proliferation, differentiation, and expression of myogenic transcriptional regulatory factors and heparan sulfate proteoglycans syndecan-4 and glypican-1.
Velleman et al., Wooster, United States. In Poult Sci, Jan 2014
The objective of the current study was to determine the effect of restricting protein synthesis on the proliferation and differentiation, expression of myogenic transcriptional regulatory factors myogenic determination factor 1, myogenin, and myogenic regulatory factor 4, and expression of the heparan sulfate proteoglycans syndecan-4 and glypican-1 in satellite cells isolated from 1-d-, 7-wk-, and 16-wk-old turkey pectoralis major muscle (1 d, 7 wk, and 16 wk cells, respectively) by using variable concentrations of Met and Cys.
The effect of syndecan-4 and glypican-1 expression on age-related changes in myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness.
Velleman et al., Wooster, United States. In Comp Biochem Physiol A Mol Integr Physiol, Dec 2013
Satellite cell proliferation, differentiation, and responsiveness to fibroblast growth factor 2 (FGF2) is, in part, regulated by the heparan sulfate proteoglycans syndecan-4 and glypican-1.
Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products.
Mani et al., In Glycobiology, Dec 2013
Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells.
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells.
Brandan et al., Santiago, Chile. In Skelet Muscle, Dec 2013
Glypican-1 is the only HSPG expressed in myoblasts that localize in lipid raft membrane domains, controlling cell responses to extracellular stimuli.
Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.
Logan et al., Lund, Sweden. In Acta Crystallogr D Biol Crystallogr, Dec 2013
A study has been carried out to establish whether controlled dehydration could be used to improve the anisotropy of crystals of the core protein of the human proteoglycan glypican-1.
The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress.
Tarbell et al., Chengdu, China. In Plos One, Dec 2013
After exposure to shear stress for 24 h, the glycocalyx components heparan sulfate, chondroitin sulfate, glypican-1 and syndecan-1, were enhanced on the apical surface, with nearly uniform spatial distributions close to baseline levels that differed greatly from the 30 min distributions.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Greenberg et al., Novato, United States. In Proc Natl Acad Sci U S A, 2012
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
Logan et al., Lund, Sweden. In J Biol Chem, 2012
Crystal structure of N-glycosylated human glypican-1 core protein shows the structure of two loops evolutionarily conserved in vertebrate glypican-1
The structural role of N-linked glycans on human glypican-1.
Mani et al., Lund, Sweden. In Biochemistry, 2011
Mutagenesis and enzymatic cleavage indicated that the potential N-glycosylation sites are invariably occupied.
Glypican-1 facilitates prion conversion in lipid rafts.
Hooper, Leeds, United Kingdom. In J Neurochem, 2011
Recently, the cell-surface HSPG glypican-1 was demonstrated to co-localise with PrP(C) on the cell surface and to promote its association with lipid rafts.
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Marquezini et al., São Paulo, Brazil. In Cardiovasc Diabetol, 2010
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Identifying gene regulatory networks in schizophrenia.
Xie et al., Irvine, United States. In Neuroimage, 2010
Glypican 1 and FGF17 mouse models for example, can be used to study such gene regulatory networks.
[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].
Zuo et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells.
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
Pancreatic cancer-associated stroma production.
Korc, United States. In Am J Surg, 2007
The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1.
Extracellular matrix of ovarian tumors.
Rodgers et al., Adelaide, Australia. In Semin Reprod Med, 2006
Elevated levels of laminin-gamma2, collagen types I and III, fibronectin, syndecan-1, glypican-1, versican, and hyaluronan and its receptors CD44 have all been associated with a poor prognosis of ovarian cancers.
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