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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Jul 2015.

Glypican 1

glypican-1, GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, syndecan-4, Fibroblast Growth Factor 2, V1a
Papers on glypican-1
Structural aspects of N-glycosylations and the C-terminal region in human glypican-1.
New
Logan et al., Lund, Sweden. In J Biol Chem, 22 Aug 2015
Glypican-1 (Gpc1) is the predominant heparan sulphate (HS) proteoglycan in the developing and adult human brain.
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.
New
Impact
Kalluri et al., Houston, United States. In Nature, 09 Aug 2015
Using mass spectrometry analyses, we identify a cell surface proteoglycan, glypican-1 (GPC1), specifically enriched on cancer-cell-derived exosomes.
Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.
New
Bakkers et al., Utrecht, Netherlands. In Development, 15 Jun 2015
In human, as in most vertebrates, six glypican-encoding genes have been identified (GPC1-6), and mutations in several glypican genes cause multiple malformations including congenital heart defects.
Genome-wide association studies in biliary atresia.
New
Sindhi et al., Pittsburgh, United States. In Wiley Interdiscip Rev Syst Biol Med, 11 Jun 2015
Although distinct, these susceptibility genes share several functions including roles in mechanisms for organogenesis (glypican 1 or GPC1, and adenosine diphosphate ribosylation factor 6, or ARF6) or a greater expression in fetal liver than in adult liver (adducin 3 or ADD3).
Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.
New
Mani et al., Lund, Sweden. In Glycobiology, May 2015
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced S-nitrosothiol-catalyzed reaction.
Proteoglycans as potential microenvironmental biomarkers for colon cancer.
New
Grigorieva et al., Novosibirsk, Russia. In Cell Tissue Res, Mar 2015
According to RT-PCR analysis, normal and cancer colon tissues expressed a specific set of PGs (syndecan-1, perlecan, decorin, biglycan, versican, NG2/CSPG4, serglycin, lumican, CD44), while the expression of glypican-1, brevican and aggrecan was almost undetectable.
Differential expression of glypican-1 in ameloblastoma variants.
New
Molina-Frechero et al., Montevideo, Uruguay. In Appl Immunohistochem Mol Morphol, Feb 2015
The expression of glypican-1 is differentially altered among different types of malignancies, suggesting a possible role in the tumorigenesis and biological behavior of these neoplasms.
Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production.
New
Hsing et al., Tainan City, Taiwan. In Int J Mol Sci, Dec 2014
In vitro, a propofol overdose reduced the expression of syndecan-1, syndecan-4, perlecan, glypican-1 mRNA and HS and induced significant decreases in the nicotinamide adenine dinucleotide (NAD+)/NADH ratio and ATP concentrations in human microvascular endothelial cells (HMEC-1).
The role of glypicans in Hedgehog signaling.
Review
New
Capurro et al., Canada. In Matrix Biol, Apr 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.
Guimaraes et al., Cambridge, United States. In Plos One, 2013
Making use of the biotinylated version of aerolysin, we identify mesothelin, urokinase plasminogen activator surface receptor (uPAR, CD87), glypican-1, and CD59 glycoprotein as aerolysin receptors, all predicted or known to be modified with a glycosylphosphatidylinositol anchor.
Regulation of Zn and Fe transporters by the GPC1 gene during early wheat monocarpic senescence.
Dubcovksy et al., In Bmc Plant Biol, 2013
We have previously shown that the simultaneous downregulation of Grain Protein Content (GPC) transcription factors, GPC1 and GPC2, greatly delays senescence and disrupts nutrient remobilization, and therefore provide a valuable entry point to identify genes involved in micronutrient transport to the wheat grain.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
GeneRIF
Greenberg et al., Novato, United States. In Proc Natl Acad Sci U S A, 2012
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
GeneRIF
Logan et al., Lund, Sweden. In J Biol Chem, 2012
Crystal structure of N-glycosylated human glypican-1 core protein shows the structure of two loops evolutionarily conserved in vertebrate glypican-1
The structural role of N-linked glycans on human glypican-1.
GeneRIF
Mani et al., Lund, Sweden. In Biochemistry, 2011
Mutagenesis and enzymatic cleavage indicated that the potential N-glycosylation sites are invariably occupied.
Glypican-1 facilitates prion conversion in lipid rafts.
Review
Hooper, Leeds, United Kingdom. In J Neurochem, 2011
Recently, the cell-surface HSPG glypican-1 was demonstrated to co-localise with PrP(C) on the cell surface and to promote its association with lipid rafts.
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
GeneRIF
Marquezini et al., São Paulo, Brazil. In Cardiovasc Diabetol, 2010
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Identifying gene regulatory networks in schizophrenia.
Review
Xie et al., Irvine, United States. In Neuroimage, 2010
Glypican 1 and FGF17 mouse models for example, can be used to study such gene regulatory networks.
[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].
GeneRIF
Zuo et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells.
Glypicans.
Review
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
Pancreatic cancer-associated stroma production.
Review
Korc, United States. In Am J Surg, 2007
The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1.
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