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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Glypican 1

glypican-1, GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, syndecan-4, Fibroblast Growth Factor 2, V1a
Papers on glypican-1
Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.
Mani et al., Lund, Sweden. In Glycobiology, 31 May 2015
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced S-nitrosothiol-catalyzed reaction.
Proteoglycans as potential microenvironmental biomarkers for colon cancer.
Grigorieva et al., Novosibirsk, Russia. In Cell Tissue Res, 26 Mar 2015
According to RT-PCR analysis, normal and cancer colon tissues expressed a specific set of PGs (syndecan-1, perlecan, decorin, biglycan, versican, NG2/CSPG4, serglycin, lumican, CD44), while the expression of glypican-1, brevican and aggrecan was almost undetectable.
Differential expression of glypican-1 in ameloblastoma variants.
Molina-Frechero et al., Montevideo, Uruguay. In Appl Immunohistochem Mol Morphol, 28 Feb 2015
The expression of glypican-1 is differentially altered among different types of malignancies, suggesting a possible role in the tumorigenesis and biological behavior of these neoplasms.
The effect of nutritional status on myogenic gene expression of satellite cells derived from different muscle types.
Velleman et al., Armidale, Australia. In Poult Sci, Sep 2014
These genes included the myogenic regulatory factors myogenic determination factor 1 (MyoD) and myogenin, the cell-membrane associated proteoglycans syndecan-4 and glypican-1, the extracellular matrix proteoglycan decorin, and the transcription factor paired box 7. Protein synthesis potential varied by the concentration of the sulfur amino acids Met and Cys during SC proliferation and differentiation.
Hippocampal proteoglycans brevican and versican are linked to spatial memory of Sprague-Dawley rats in the morris water maze.
Lubec et al., Vienna, Austria. In J Neurochem, Sep 2014
PGs agrin, amyloid beta A4 protein, brevican, glypican-1, neurocan, phosphacan, syndecan-4, and versican were identified in the hippocampi.
EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.
Karamanos et al., Pátrai, Greece. In Biochim Biophys Acta, Aug 2014
However, glypican-1 upregulation by EGF is mainly mediated via HER2.
Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.
Mani et al., In J Biol Chem, Aug 2014
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 is generated in endosomes by an endogenously or ascorbate-induced S-nitrosothiolcatalyzed reaction.
Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth.
Blobe et al., In J Clin Invest, Jul 2014
We demonstrated that expression of heparan sulfate proteoglycans (HSPGs), including TβRIII, GPC1, GPC3, SDC3, and SDC4, is low in neuroblasts and high in the Schwannian stroma.
The role of glypicans in Hedgehog signaling.
Capurro et al., Canada. In Matrix Biol, Apr 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
Regulation of Zn and Fe transporters by the GPC1 gene during early wheat monocarpic senescence.
Dubcovksy et al., In Bmc Plant Biol, 2013
We have previously shown that the simultaneous downregulation of Grain Protein Content (GPC) transcription factors, GPC1 and GPC2, greatly delays senescence and disrupts nutrient remobilization, and therefore provide a valuable entry point to identify genes involved in micronutrient transport to the wheat grain.
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.
Guimaraes et al., Cambridge, United States. In Plos One, 2013
Making use of the biotinylated version of aerolysin, we identify mesothelin, urokinase plasminogen activator surface receptor (uPAR, CD87), glypican-1, and CD59 glycoprotein as aerolysin receptors, all predicted or known to be modified with a glycosylphosphatidylinositol anchor.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Greenberg et al., Novato, United States. In Proc Natl Acad Sci U S A, 2012
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
Logan et al., Lund, Sweden. In J Biol Chem, 2012
Crystal structure of N-glycosylated human glypican-1 core protein shows the structure of two loops evolutionarily conserved in vertebrate glypican-1
The structural role of N-linked glycans on human glypican-1.
Mani et al., Lund, Sweden. In Biochemistry, 2011
Mutagenesis and enzymatic cleavage indicated that the potential N-glycosylation sites are invariably occupied.
Glypican-1 facilitates prion conversion in lipid rafts.
Hooper, Leeds, United Kingdom. In J Neurochem, 2011
Recently, the cell-surface HSPG glypican-1 was demonstrated to co-localise with PrP(C) on the cell surface and to promote its association with lipid rafts.
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Marquezini et al., São Paulo, Brazil. In Cardiovasc Diabetol, 2010
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Identifying gene regulatory networks in schizophrenia.
Xie et al., Irvine, United States. In Neuroimage, 2010
Glypican 1 and FGF17 mouse models for example, can be used to study such gene regulatory networks.
[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].
Zuo et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells.
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
Pancreatic cancer-associated stroma production.
Korc, United States. In Am J Surg, 2007
The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1.
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