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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Nov 2015.

Glypican 1

glypican-1, GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, syndecan-4, Fibroblast Growth Factor 2, V1a
Papers on glypican-1
Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines.
Grigorieva et al., Novosibirsk, Russia. In Oncotarget, 16 Nov 2015
In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2, HS6ST1/2, SULF1/2, HPSE) and extracellular matrix (ECM) components (collagen 1A1, fibronectin, elastin) in primary B cells and EBV carrying cell lines with different phenotypes, patterns of EBV-host cell interaction and viral latency stages (type I-III) was investigated.
Genome-wide association studies in biliary atresia.
Sindhi et al., Pittsburgh, United States. In Wiley Interdiscip Rev Syst Biol Med, Sep 2015
Although distinct, these susceptibility genes share several functions including roles in mechanisms for organogenesis (glypican 1 or GPC1, and adenosine diphosphate ribosylation factor 6, or ARF6) or a greater expression in fetal liver than in adult liver (adducin 3 or ADD3).
Proteoglycans as potential microenvironmental biomarkers for colon cancer.
Grigorieva et al., Novosibirsk, Russia. In Cell Tissue Res, Sep 2015
According to RT-PCR analysis, normal and cancer colon tissues expressed a specific set of PGs (syndecan-1, perlecan, decorin, biglycan, versican, NG2/CSPG4, serglycin, lumican, CD44), while the expression of glypican-1, brevican and aggrecan was almost undetectable.
Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.
Mani et al., Lund, Sweden. In Glycoconj J, Sep 2015
UNASSIGNED: Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.
Kalluri et al., Houston, United States. In Nature, Aug 2015
Using mass spectrometry analyses, we identify a cell surface proteoglycan, glypican-1 (GPC1), specifically enriched on cancer-cell-derived exosomes.
Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.
Bakkers et al., Utrecht, Netherlands. In Development, Jun 2015
In human, as in most vertebrates, six glypican-encoding genes have been identified (GPC1-6), and mutations in several glypican genes cause multiple malformations including congenital heart defects.
Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.
Mani et al., Lund, Sweden. In Glycobiology, May 2015
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced S-nitrosothiol-catalyzed reaction.
Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character.
Quirós et al., Spain. In Bmc Cancer, Dec 2014
RESULTS: Changes in proteoglycan core proteins differ depending on their location; those located intracellularly or in the extracellular matrix show very similar alteration patterns, while those located on the cell surface vary greatly depending on the nature of the tumor: glypicans 1, 3, 6 and betaglycan are affected in the non-metastatic tumors, whereas in the metastatic, only glypican-1 and syndecan-1 are modified, the latter showing opposing alterations in levels of RNA and of protein, suggesting post-transcriptional regulation in these tumors.
Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production.
Hsing et al., Tainan City, Taiwan. In Int J Mol Sci, Dec 2014
In vitro, a propofol overdose reduced the expression of syndecan-1, syndecan-4, perlecan, glypican-1 mRNA and HS and induced significant decreases in the nicotinamide adenine dinucleotide (NAD+)/NADH ratio and ATP concentrations in human microvascular endothelial cells (HMEC-1).
The role of glypicans in Hedgehog signaling.
Capurro et al., Canada. In Matrix Biol, Apr 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
Regulation of Zn and Fe transporters by the GPC1 gene during early wheat monocarpic senescence.
Dubcovksy et al., In Bmc Plant Biol, 2013
We have previously shown that the simultaneous downregulation of Grain Protein Content (GPC) transcription factors, GPC1 and GPC2, greatly delays senescence and disrupts nutrient remobilization, and therefore provide a valuable entry point to identify genes involved in micronutrient transport to the wheat grain.
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.
Guimaraes et al., Cambridge, United States. In Plos One, 2013
Making use of the biotinylated version of aerolysin, we identify mesothelin, urokinase plasminogen activator surface receptor (uPAR, CD87), glypican-1, and CD59 glycoprotein as aerolysin receptors, all predicted or known to be modified with a glycosylphosphatidylinositol anchor.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Greenberg et al., Novato, United States. In Proc Natl Acad Sci U S A, 2012
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
Logan et al., Lund, Sweden. In J Biol Chem, 2012
Crystal structure of N-glycosylated human glypican-1 core protein shows the structure of two loops evolutionarily conserved in vertebrate glypican-1
The structural role of N-linked glycans on human glypican-1.
Mani et al., Lund, Sweden. In Biochemistry, 2011
Mutagenesis and enzymatic cleavage indicated that the potential N-glycosylation sites are invariably occupied.
Glypican-1 facilitates prion conversion in lipid rafts.
Hooper, Leeds, United Kingdom. In J Neurochem, 2011
Recently, the cell-surface HSPG glypican-1 was demonstrated to co-localise with PrP(C) on the cell surface and to promote its association with lipid rafts.
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Marquezini et al., São Paulo, Brazil. In Cardiovasc Diabetol, 2010
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Identifying gene regulatory networks in schizophrenia.
Xie et al., Irvine, United States. In Neuroimage, 2010
Glypican 1 and FGF17 mouse models for example, can be used to study such gene regulatory networks.
[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].
Zuo et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells.
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
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