gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glypican 1

glypican-1, GPC1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, syndecan-4, Fibroblast Growth Factor 2, V1a
Papers on glypican-1
MicroRNA regulation of myogenic satellite cell proliferation and differentiation.
New
Velleman et al., Wooster, United States. In Mol Cell Biochem, Jan 2016
Two genes essential to satellite cell function are syndecan-4 and glypican-1.
Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines.
New
Grigorieva et al., Novosibirsk, Russia. In Oncotarget, Jan 2016
In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2, HS6ST1/2, SULF1/2, HPSE) and extracellular matrix (ECM) components (collagen 1A1, fibronectin, elastin) in primary B cells and EBV carrying cell lines with different phenotypes, patterns of EBV-host cell interaction and viral latency stages (type I-III) was investigated.
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination.
New
Haupt et al., Brisbane, Australia. In Stem Cell Res, Jan 2016
Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions.
Regional specific modulation of the glycocalyx and smooth muscle cell contractile apparatus in conduit arteries of tail-suspended rats.
New
Deng et al., Beijing, China. In J Appl Physiol, Jan 2016
The relative mRNA levels of syndecan-2, 3, 4, glypican-1, smooth muscle protein 22 (SM22), smoothelin (SMTN), and calponin were enhanced to 1.40, 1.53, 1.70, 1.90, 2.93, 2.30, and 5.23-fold respectively in the common carotid artery of the TS rat.
Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.
New
Mani et al., Lund, Sweden. In Glycoconj J, Dec 2015
Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.
Proteoglycans as potential microenvironmental biomarkers for colon cancer.
New
Grigorieva et al., Novosibirsk, Russia. In Cell Tissue Res, Sep 2015
According to RT-PCR analysis, normal and cancer colon tissues expressed a specific set of PGs (syndecan-1, perlecan, decorin, biglycan, versican, NG2/CSPG4, serglycin, lumican, CD44), while the expression of glypican-1, brevican and aggrecan was almost undetectable.
Genome-wide association studies in biliary atresia.
Review
New
Sindhi et al., Pittsburgh, United States. In Wiley Interdiscip Rev Syst Biol Med, Sep 2015
Although distinct, these susceptibility genes share several functions including roles in mechanisms for organogenesis (glypican 1 or GPC1, and adenosine diphosphate ribosylation factor 6, or ARF6) or a greater expression in fetal liver than in adult liver (adducin 3 or ADD3).
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.
New
Impact
Kalluri et al., Houston, United States. In Nature, Aug 2015
Using mass spectrometry analyses, we identify a cell surface proteoglycan, glypican-1 (GPC1), specifically enriched on cancer-cell-derived exosomes.
Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.
New
Bakkers et al., Utrecht, Netherlands. In Development, Jun 2015
In human, as in most vertebrates, six glypican-encoding genes have been identified (GPC1-6), and mutations in several glypican genes cause multiple malformations including congenital heart defects.
Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character.
Quirós et al., Spain. In Bmc Cancer, 2014
RESULTS: Changes in proteoglycan core proteins differ depending on their location; those located intracellularly or in the extracellular matrix show very similar alteration patterns, while those located on the cell surface vary greatly depending on the nature of the tumor: glypicans 1, 3, 6 and betaglycan are affected in the non-metastatic tumors, whereas in the metastatic, only glypican-1 and syndecan-1 are modified, the latter showing opposing alterations in levels of RNA and of protein, suggesting post-transcriptional regulation in these tumors.
Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production.
Hsing et al., Tainan City, Taiwan. In Int J Mol Sci, 2014
In vitro, a propofol overdose reduced the expression of syndecan-1, syndecan-4, perlecan, glypican-1 mRNA and HS and induced significant decreases in the nicotinamide adenine dinucleotide (NAD+)/NADH ratio and ATP concentrations in human microvascular endothelial cells (HMEC-1).
The role of glypicans in Hedgehog signaling.
Review
Capurro et al., Canada. In Matrix Biol, 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
GeneRIF
Greenberg et al., Novato, United States. In Proc Natl Acad Sci U S A, 2012
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
GeneRIF
Logan et al., Lund, Sweden. In J Biol Chem, 2012
Crystal structure of N-glycosylated human glypican-1 core protein shows the structure of two loops evolutionarily conserved in vertebrate glypican-1
The structural role of N-linked glycans on human glypican-1.
GeneRIF
Mani et al., Lund, Sweden. In Biochemistry, 2011
Mutagenesis and enzymatic cleavage indicated that the potential N-glycosylation sites are invariably occupied.
Glypican-1 facilitates prion conversion in lipid rafts.
Review
Hooper, Leeds, United Kingdom. In J Neurochem, 2011
Recently, the cell-surface HSPG glypican-1 was demonstrated to co-localise with PrP(C) on the cell surface and to promote its association with lipid rafts.
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
GeneRIF
Marquezini et al., São Paulo, Brazil. In Cardiovasc Diabetol, 2010
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Identifying gene regulatory networks in schizophrenia.
Review
Xie et al., Irvine, United States. In Neuroimage, 2010
Glypican 1 and FGF17 mouse models for example, can be used to study such gene regulatory networks.
[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].
GeneRIF
Zuo et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells.
Glypicans.
Review
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
share on facebooktweetadd +1mail to friends