Sequential Notch activation regulates ventricular chamber development.
Madrid, Spain. In Nat Cell Biol, Jan 2016
We show that Notch signalling first connects chamber endocardium and myocardium to sustain trabeculation, and later coordinates ventricular patterning and compaction with coronary vessel development to generate the mature chamber, through a temporal sequence of ligand signalling determined by the glycosyltransferase manic fringe (MFng).
Phylogeny, structure, function, biosynthesis and evolution of sulfated galactose-containing glycans.
Rio de Janeiro, Brazil. In Int J Biol Macromol, Jan 2016
Although future investigations in molecular biology must be still performed in order to assure certain hypotheses, empirical evidences based on structural biology of the sulfated galactose-containing glycans among different species particularly their backbone and sulfation patterns clearly indicate great specificity in terms of glycosyltransferase and sulfotransferase activity.
Bacterial glycosyltransferase toxins.
Freiburg, Germany. In Cell Microbiol, Dec 2015
Prototypic for this group of glycosyltransferase toxins are Clostridium difficile toxins A and B, which modify guanine nucleotide-binding proteins of the Rho family.
Engineered CHO cells for production of diverse, homogeneous glycoproteins.
Copenhagen, Denmark. In Nat Biotechnol, Aug 2015
We conducted a comprehensive knockout screen of glycosyltransferase genes controlling N-glycosylation in CHO cells and constructed a design matrix that facilitates the generation of desired glycosylation, such as human-like α2,6-linked sialic acid capping.
Synthetic self-adjuvanting glycopeptide cancer vaccines.
Sydney, Australia. In Front Chem, 2014
Due to changes in glycosyltransferase expression during oncogenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Boston, United States. In Science, 2014
Host cell factor-1 (HCF-1), a transcriptional co-regulator of human cell-cycle progression, undergoes proteolytic maturation in which any of six repeated sequences is cleaved by the nutrient-responsive glycosyltransferase, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT).