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Duffy blood group, chemokine receptor

glycoprotein D, DARC, Duffy blood group antigen
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on glycoprotein D
Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche.
Deng et al., Shanghai, China. In Sci China Life Sci, 2012
Data suggest that DARC (Duffy antigen receptor for chemokines) gene may play an important role in regulating the metabolisms of both lean body mass (LBM) and age at menarche (AAM).
DARC alleles and Duffy phenotypes in African Americans.
Flegel et al., Bethesda, United States. In Transfusion, 2012
We developed a phylogenetic tree for DARC alleles and postulated a distinct FY*B allele as ancestral for the extant DARC alleles in humans.
The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
National Heart et al., San Francisco, United States. In Chest, 2012
Our results provide evidence that the functional rs2814778 polymorphism in the gene encoding DARC is associated with worse clinical outcomes among African Americans with ALI, possibly via an increase in circulating IL-8.
Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria.
Zimmerman et al., Cleveland, United States. In Proc Natl Acad Sci U S A, 2012
findings show that Fy(a), compared with Fy(b), significantly diminishes binding of Pv Duffy binding protein (PvDBP) at the erythrocyte surface, and is associated with a reduced risk of clinical Plasmodium vivax in humans
The genetics of benign neutropenia.
Ziv et al., Israel. In Isr Med Assoc J, 2011
Here we describe the recent success in mapping the gene that underlies benign neutropenia in African American populations. We discuss the known function of the gene and consider potential mechanisms for the effect on neutropenia.[review]
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