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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glycophorin A

Glycophorin, glycophorin A
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, CD45, erythropoietin
Papers using Glycophorin antibodies
Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
Supplier
Rouhi Arefeh et al., In Molecular Cancer, 2002
... expressing the following lineage (lin) markers: CD2, CD3, CD14, CD16, CD19, CD24, CD56, CD66b and glycophorin A were removed immunomagnetically using a column (StemSep, StemCell Technologies, Vancouver, BC) as recommended ...
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
Supplier
Yaacob Nik Soriani et al., In Clinical and Developmental Immunology, 1998
... , and glycophorin A (Miltenyi Biotec, Germany) ...
Papers on Glycophorin
Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms.
Review
New
Sugita et al., Wako, Japan. In Biochim Biophys Acta, Feb 2016
As application examples, we introduce recent simulation studies of glycophorin A, phospholamban, amyloid precursor protein, and mixed lipid bilayers and discuss the accuracy and efficiency of each simulation model and method.
Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase.
New
Call et al., Australia. In J Am Chem Soc, Jan 2016
Here we examine this issue using the glycophorin A (GpA) model system, whose homodimeric TM helix interface has been characterized by solution and solid-state NMR and biochemical techniques but never crystallographically.
Applicability of three commercially available kits for forensic identification of blood stains.
New
Mrsic et al., Zagreb, Croatia. In J Forensic Leg Med, Jan 2016
This study evaluated two hemoglobin tests, ABAcard(®) HemaTrace(®) and HemDirect Hemoglobin against glycophorin A test-RSID™-Blood for following parameters: sensitivity, specificity, effectiveness using various substrates, stain remover and aged blood stains.
Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function.
New
Ghiran et al., Kyoto, Japan. In Plos One, Dec 2015
In this study, using luminometric- and fluorescence-based methods, we show that ligation of glycophorin A (GPA) on human red blood cells (RBCs) results in a 2.1-fold, NADPH-oxidase-dependent increase in intracellular ROS that, in turn, trigger multiple downstream cascades leading to caspase-3 activation, ATP release, and increased band 3 phosphorylation.
Crosstalk between red blood cells and the immune system and its impact on atherosclerosis.
Review
Riganò et al., Roma, Italy. In Biomed Res Int, 2014
This review reports current knowledge on the impact of oxidative stress in RBC modifications with the surface appearance of senescent signals characterized by reduced expression of CD47 and glycophorin A and higher externalization of phosphatidylserine.
Pathology of human plaque vulnerability: mechanisms and consequences of intraplaque haemorrhages.
Review
Ho-Tin-Noé et al., Paris, France. In Atherosclerosis, 2014
The presence of iron, glycophorin A and ceroids provides evidence of RBCs.
Pathology of plaque haemorrhage and neovascularization of coronary artery.
Review
Arbustini et al., Pavia, Italy. In J Cardiovasc Med (hagerstown), 2012
In the past decade, the use of anti-Glycophorin A antibodies that specifically and uniquely label membranes of the red cells triggered a cascade of pathologic and experimental studies concordantly documenting not only the presence but also the major role of IPH in plaque progression and complications.
Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1.
GeneRIF
Alper et al., Boston, United States. In Biochem Cell Biol, 2011
Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1, that G719D mutation renders Ae1 mutant constructs GPA-unresponsive, and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness.
Beta-branched residues adjacent to GG4 motifs promote the efficient association of glycophorin A transmembrane helices.
GeneRIF
Deber et al., Toronto, Canada. In Biopolymers, 2010
Beta-branched residues adjacent to GG4 motifs promote the efficient association of glycophorin A transmembrane helices.
Chromosome 4q31 locus in COPD is also associated with lung cancer.
GeneRIF
Gamble et al., Auckland, New Zealand. In Eur Respir J, 2010
the GG genotype of the rs 1489759 HHIP single-nucleotide polymorphism (SNP) and the CC genotype of the rs 2202507 GYPA SNP confers a ''protective'' effect on COPD (OR 0.59, p50.006 for HHIP and OR50.65, p50.006 for GYPA) and lung cancer.
The membrane environment modulates self-association of the human GpA TM domain--implications for membrane protein folding and transmembrane signaling.
GeneRIF
Schneider et al., Mainz, Germany. In Biochim Biophys Acta, 2010
Data indicate that changes of the glycophorin A dimerization propensities in different lipid bilayers suggest that the lipid bilayer thickness severely influences the monomer-dimer equilibrium of the transmembrane domain.
ABH blood group antigens in N-glycan of human glycophorin A.
GeneRIF
Krotkiewski et al., Umeå, Sweden. In Arch Biochem Biophys, 2010
ABH blood group antigens in N-glycan of human glycophorin A.
Molecular dynamics simulations of the dimerization of transmembrane alpha-helices.
Impact
Sansom et al., Oxford, United Kingdom. In Acc Chem Res, 2010
The glycophorin A (GpA) TM helix dimer represents a paradigm for helix-helix packing, mediated by a GxxxG sequence motif.
MNS blood group system: a review.
Review
Reid, New York City, United States. In Immunohematology, 2008
The MNS antigens are carried on glycophorin A (GPA), glycophorin B (GPB), or hybrids thereof, which arise from single-nucleotide substitution, unequal crossing over, or gene conversion between the glycophorin genes.
Helix Interactions in Membranes:  Lessons from Unrestrained Monte Carlo Simulations.
Efremov et al., Moscow, Russia. In J Chem Theory Comput, 2005
The method is tested in calculations of two hydrophobic segments of human glycophorin A (GpA), known to form membrane-spanning dimers in real lipid bilayers.
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.
Impact
Joshua-Tor et al., New York City, United States. In Cell, 2005
Erythrocyte binding antigen 175 (EBA-175) is a P. falciparum protein that binds the major glycoprotein found on human erythrocytes, glycophorin A, during invasion.
Environmental Effects on Glycophorin A Folding and Structure Examined through Molecular Simulations.
Woolf et al., New Haven, United States. In J Chem Theory Comput, 2005
The human erythrocyte sialoglycoprotein glycophorin A (GpA) has been used extensively in experiment and simulations as a model of transmembrane helix-dimer formation, emphasizing the critical role of specific residue-residue interactions between helices in dimer stability.
Intraplaque hemorrhage and progression of coronary atheroma.
Impact
Virmani et al., Washington, D.C., United States. In N Engl J Med, 2004
METHODS: We stained multiple coronary lesions from 24 randomly selected patients who had died suddenly of coronary causes with an antibody against glycophorin A (a protein specific to erythrocytes that facilitates anion exchange) and Mallory's stain for iron (hemosiderin), markers of previous intraplaque hemorrhage.
Expression of Bcl-x in erythroid precursors from patients with polycythemia vera.
Impact
Fernández-Luna et al., Santander, Spain. In N Engl J Med, 1998
Bone marrow mononuclear cells from 8 healthy bone marrow donors, 14 patients with polycythemia vera, 19 patients with other myeloproliferative syndromes, and 12 patients with secondary erythrocytosis were analyzed by flow cytometry with antibodies against Bcl-x and glycophorin A, an erythroid marker.
A transmembrane helix dimer: structure and implications.
Impact
Engelman et al., New Haven, United States. In Science, 1997
The three-dimensional structure of the dimeric transmembrane domain of glycophorin A (GpA) was determined by solution nuclear magnetic resonance spectroscopy of a 40-residue peptide solubilized in aqueous detergent micelles.
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