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Hydroxyacid oxidase

glycolate oxidase, hydroxyacid oxidase, Hao-1
catalyzes the oxidation of glycolate to glyoxylate and H2O2; may be involved in response to oxidative stress [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, catalase, CAN, HAD, V1a
Papers on glycolate oxidase
Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
New
Holmes et al., Birmingham, United States. In Biochim Biophys Acta, Feb 2016
To determine if blocking steps in hydroxyproline and glycolate metabolism would decrease urinary oxalate excretion, mice were injected with siRNA targeting the liver enzymes glycolate oxidase and hydroxyproline dehydrogenase.
NADPH oxidases differentially regulate ROS metabolism and nutrient uptake under cadmium toxicity.
New
Sandalio et al., Granada, Spain. In Plant Cell Environ, Feb 2016
Cadmium increased catalase activity in WT plants and decreased it in Atrboh mutants, while glutathione reductase and glycolate oxidase activities increased in Atrboh mutants, and superoxide dismutases were down-regulated in AtrbohC.
Inhibition of Glycolate Oxidase with Dicer-Substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type I.
New
Lai et al., Santa Cruz de Tenerife, Spain. In Mol Ther, Feb 2016
We explored an alternative approach to prevent glyoxylate production using Dicer-substrate small interfering RNAs (DsiRNAs) targeting hydroxyacid oxidase 1 (HAO1) mRNA which encodes glycolate oxidase (GO), to reduce the hepatic conversion of glycolate to glyoxylate.
Glycolate oxidase is a safe and efficient target for substrate reduction therapy in a mouse model of Primary Hyperoxaluria Type I.
New
Salido et al., Santa Cruz de Tenerife, Spain. In Mol Ther, Jan 2016
Glycolate is one of the best-known substrates leading to glyoxylate production, via peroxisomal glycolate oxidase (GO).
Towards an effective biosensor for monitoring AD leachate: a knockout E. coli mutant that cannot catabolise lactate.
New
McDonnell et al., Dublin, Ireland. In Appl Microbiol Biotechnol, Dec 2015
Successive gene knockouts of E.coli W3110 D-lactate dehydrogenase (dld), L-lactate dehydrogenase (lldD), glycolate oxidase (glcD) and a suspected L-lactate dehdrogenase (ykgF) were performed.
GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis.
New
Maurino et al., Potsdam, Germany. In Plant Physiol, Oct 2015
Here, we identify the Arabidopsis glycolate oxidase (GOX) paralogs GOX1, GOX2, and GOX3 as putative l-lactate-metabolizing enzymes based on their homology to CYB2, the l-lactate cytochrome c oxidoreductase from the yeast Saccharomyces cerevisiae.
Activation of cyclic electron flow by hydrogen peroxide in vivo.
New
Kramer et al., Düsseldorf, Germany. In Proc Natl Acad Sci U S A, May 2015
CEF was strongly increased by H2O2 both by infiltration or in situ production by chloroplast-localized glycolate oxidase, implying that H2O2 can activate CEF either directly by redox modulation of key enzymes, or indirectly by affecting other photosynthetic processes.
The Ala95-to-Gly substitution in Aerococcus viridans l-lactate oxidase revisited - structural consequences at the catalytic site and effect on reactivity with O2 and other electron acceptors.
New
Nidetzky et al., Graz, Austria. In Febs J, Feb 2015
The increased steric volume available in the active site allows the A95G variant to exhibit a similar trend with the related glycolate oxidase in electron acceptor substrate specificities, despite the latter containing an alanine at the analogous position.
Experimental evidence for a hydride transfer mechanism in plant glycolate oxidase catalysis.
New
Hodges et al., Orsay, France. In J Biol Chem, Feb 2015
In plants, glycolate oxidase is involved in the photorespiratory cycle, one of the major fluxes at the global scale.
Peroxisomal enzymes in the liver of rats with experimental diabetes mellitus type 2.
Mojto et al., Bratislava, Slovakia. In Physiol Res, 2013
Despite of well-known induction of peroxisomal beta-oxidation, the activities of catalase, aminoacid oxidase and NADH-cytochrome b(5) reductase were not significantly changed and the activities of glycolate oxidase and NADP-isocitrate dehydrogenase were significantly decreased.
Role of peroxisomes as a source of reactive oxygen species (ROS) signaling molecules.
Review
del Río et al., Granada, Spain. In Subcell Biochem, 2012
The use of catalase and glycolate oxidase loss-of-function mutants has allowed to study the consequences of changes in the levels of endogenous H2O2 in peroxisomes and has improved our knowledge of the transcriptomic profile of genes regulated by peroxisomal ROS.
Involvement of ionizable groups in catalysis of human liver glycolate oxidase.
GeneRIF
Gadda et al., Atlanta, United States. In J Biol Chem, 2009
The turnover of the enzyme and the rate constant for flavin were pH-independent, suggesting the involvement of an unprotonated group acting as a base in the chemical step of glycolate oxidation.
Plant peroxisomes respire in the light: some gaps of the photorespiratory C2 cycle have become filled--others remain.
Review
Weber et al., Göttingen, Germany. In Biochim Biophys Acta, 2006
The H2O2-producing enzyme glycolate oxidase, catalase, and several aminotransferases of the photorespiratory cycle are located in peroxisomes, with catalase representing the major constituent of the peroxisomal matrix in photosynthetic tissues.
Oxidative stress-mediated down-regulation of rat hydroxyacid oxidase 1, a liver-specific peroxisomal enzyme.
GeneRIF
Cairo et al., Milano, Italy. In Hepatology, 2003
Down-regulation of Hao1 during oxidative stress may provide mechanism to prevent excessive H2O2 formation in liver peroxisomes. May be prototype of response to oxidative injury involving down-regulation of reactive oxygen species-producing enzymes.
Biochemical dissection of photorespiration.
Review
Neuburger et al., Grenoble, France. In Curr Opin Plant Biol, 1999
Progress has been made in the understanding of photorespiration and related proteins (Rubisco, glycolate oxidase and glycine decarboxylase) in the context of recent structural information.
Pharmacological approaches in the treatment of primary hyperoxaluria.
Review
Holmes, Winston-Salem, United States. In J Nephrol, 1998
It is suggested that an ideal drug may be an antisense oligonucleotide that blocks the expression of glycolate oxidase, a key enzyme in hepatic oxalate synthesis.
How proteins get into microbodies (peroxisomes, glyoxysomes, glycosomes).
Review
Borst, In Biochim Biophys Acta, 1986
In contrast, D-amino-acid oxidase, L-alpha-hydroxyacid oxidase and catalase levels are normal.
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