Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
Philadelphia, United States. In Curr Opin Hematol, Jan 2016
Furthermore, several endogenous inhibitory mechanisms of leukocyte recruitment have been identified, including the secreted molecules Del-1, PTX3, and GDF-15, which block distinct steps of the leukocyte adhesion cascade, as well as novel regulatory signaling pathways, involving the protein kinase AKT1 and IFN-λ2/IL-28A.
Diabetes mellitus related biomarker: The predictive role of growth-differentiation factor-15.
Ukraine. In Diabetes Metab Syndr, Nov 2015
UNASSIGNED: Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the regulation of the inflammatory response, growth and cell differentiation.