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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glycine N-methyltransferase

Glycine N-Methyltransferase, GNMT, glycine methyltransferase
catalyzes the conversion of S-adenosyl-L-methionine and glycine to S-adenosyl-L-homocysteine and sarcosine; involved in S-adenosylmethionine and folate metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, HAD, AdoMet, CAN, V1a
Papers on Glycine N-Methyltransferase
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
New
Varela-Rey et al., Spain. In J Hepatol, Feb 2016
BACKGROUND & AIMS: Glycine N-methyltransferase (GNMT) expression is decreased in some patients with severe non-alcoholic fatty liver disease.
Proteomics analysis of liver tissues from C57BL/6J mice receiving low-dose (137)Cs radiation.
New
Ding et al., Hengyang, China. In Environ Sci Pollut Res Int, Feb 2016
Western blot analysis showed that catalase (CAT), glycine N-methyltransferase (GNMT), and glutathione S-transferase P1 (GSTP1) were up-regulated in the irradiated group; these results were in agreement with qPCR results.
Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer-induced cachexia progression in Walker-256 tumor-bearing rats.
New
Guarnier et al., Londrina, Brazil. In Amino Acids, Feb 2016
Impaired Hcy metabolism was evidenced by decreased hepatic betaine-homocysteine methyltransferase (Bhmt), glycine N-methyltransferase (Gnmt) and cystathionine beta synthase (CBS) gene expression.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
New
Zhao et al., Nanjing, China. In Sci Rep, Dec 2015
Homocysteine concentration in follicular fluid was significantly higher in PCO group, which was associated with significantly up-regulated one-carbon metabolic enzymes betaine homocysteine methyltransferase (BHMT), glycine N-methyltransferase (GNMT) and the DNA methyltransferase DNMT1.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver.
New
Richter et al., Valdivia, Chile. In Physiol Genomics, Dec 2015
Different markers of nonalcoholic fatty liver disease were either upregulated (e.g., Ndn and Pnpla3) or downregulated (e.g., Gnmt, Bhmt1/2, Sult1a1, Mpo, and Mat1a).
Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
New
Zhao et al., Nanjing, China. In J Agric Food Chem, Dec 2015
Concurrently, maternal betaine supplementation increased the plasma betaine concentration and muscle expression of methyl transfer enzymes (p < 0.05), BHMT and GNMT, in offspring piglets.
Population-specific renal proteomes of marine and freshwater three-spined sticklebacks.
New
Almaas et al., Davis, United States. In J Proteomics, Nov 2015
It contains 33 of 49 proteins that are elevated in marine compared to freshwater sticklebacks, including the most highly elevated proteins (dimethylaniline monooxygenase, alanine-glyoxylate aminotransferase, glycine N-methyltransferase). Freshwater stickleback kidneys contain elevated levels of proteolytic, cytoskeletal, extracellular matrix, and calcium signaling proteins.
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Miura et al., Tokyo, Japan. In Nat Commun, 2014
Here, we show that, as an alternative to inhibiting SAM synthesis, enhancement of SAM catabolism by glycine N-methyltransferase (Gnmt) extends the lifespan in Drosophila.
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Chiang et al., Zhongxing, China. In J Nutr Sci Vitaminol (tokyo), 2014
We extensively investigated how gene-nutrient interactions may modulate human cancer risk in 2 major folate metabolic genes, MTHFR and GNMT.
Mathematical analysis of the regulation of competing methyltransferases.
Nijhout et al., Durham, United States. In Bmc Syst Biol, 2014
RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity.
The role of genetics in the establishment and maintenance of the epigenome.
Review
Fraga et al., Oviedo, Spain. In Cell Mol Life Sci, 2013
In addition, mutations in glycine-N-methyltransferase (GNMT) could be associated with a higher risk of hepatocellular carcinoma and liver disease due to an unbalanced S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio, which leads to aberrant methylation reactions.
The multi-functional roles of GNMT in toxicology and cancer.
Review
Chen et al., Taipei, Taiwan. In Toxicol Appl Pharmacol, 2013
Although glycine N-methyltransferase (GNMT) has been discovered for five decades, its function was not elucidated until recently.
S-adenosylmethionine in liver health, injury, and cancer.
Review
Impact
Mato et al., Los Angeles, United States. In Physiol Rev, 2012
This can result from inactive mutation of the enzyme glycine N-methyltransferase (GNMT).
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
GeneRIF
Martínez-Chantar et al., Spain. In Gastroenterology, 2012
Reduced expression of GNMT in mouse hepatoma cells appears to increase the activity of LKB1/RAS signaling.
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase.
GeneRIF
Beraza et al., Spain. In Hepatology, 2012
NK cells from GNMT(-/-) mice were spontaneously activated, expressed more TRAIL, and had strong cytotoxic activity, suggesting their contribution to the proinflammatory environment in the liver.
Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.
GeneRIF
Chen et al., Taipei, Taiwan. In Mol Med, 2011
In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway
Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis.
GeneRIF
Chen et al., Taipei, Taiwan. In Mol Med, 2011
This is the first report demonstrating that GNMT plays an important role in regulating cholesterol homeostasis via interaction with NPC2
Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice.
GeneRIF
Lee et al., Taipei, Taiwan. In Mol Med, 2011
GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis.
Hypermethioninemias of genetic and non-genetic origin: A review.
Review
Mudd, Bethesda, United States. In Am J Med Genet C Semin Med Genet, 2011
(3) Glycine N-methyltrasferase (GNMT) deficiency.
Inherited disorders in the conversion of methionine to homocysteine.
Review
Barić, Zagreb, Croatia. In J Inherit Metab Dis, 2009
Interest has been stimulated by the discovery of two novel disorders, glycine N-methyltransferase deficiency and S-adenosylhomocysteine hydrolase deficiency.
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