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Serine hydroxymethyltransferase 1

Glycine Hydroxymethyltransferase, SHMT, 14 kDa protein, SHMT1
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, methylenetetrahydrofolate reductase, HAD, CAN, SRA
Papers on Glycine Hydroxymethyltransferase
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.
Smith et al., Houston, United States. In Faseb J, Jan 2016
We investigated 5 polymorphisms in the methionine synthase reductase (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cystathionine β-synthase (CBS) genes and their association with ophthalmic changes after flight in 49 astronauts.
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells.
Cutruzzolà et al., Roma, Italy. In Oncotarget, Jan 2016
UNASSIGNED: Serine hydroxymethyltransferase (SHMT) is a central enzyme in the metabolic reprogramming of cancer cells, providing activated one-carbon units in the serine-glycine one-carbon metabolism.
Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
Chopra et al., Pune, India. In Pharmacogenomics, Dec 2015
RESULTS: Polymorphisms in GGH, SHMT1 and TS were associated with MTX-related adverse events while SNPs in MTHFR and RFC1/SLC19A1 were associated with MTX efficacy.
miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.
Zhao et al., Zhengzhou, China. In Tumour Biol, Dec 2015
In this study, quantitative real-time PCR was applied to study miR-198 and serine hydroxymethyltransferase 1 (SHMT1) expression in 47 paired lung adenocarcinoma tissues and adjacent nontumor lung tissues.
Comparative analysis of four disease prediction models of Parkinson's disease.
Kutala et al., Hyderābād, India. In Mol Cell Biochem, Nov 2015
The RP model showed SHMT C1420T as important determinant of PD risk.
Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.
Veysey et al., Newcastle, Australia. In Bba Clin, Jun 2015
Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS.
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
Zheng et al., Shanghai, China. In Ai Zheng, Mar 2015
BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit.
The molecular cloning and clarification of a photorespiratory mutant, oscdm1, using enhancer trapping.
Lu et al., Beijing, China. In Front Genet, 2014
An analysis of the T-DNA flanking sequence in the oscdm1 plants showed that the T-DNA was inserted into the promoter region of a serine hydroxymethyltransferase (SHMT) gene.
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
Chen et al., Nanjing, China. In Genet Mol Res, 2014
Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results.
2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica.
Downs et al., Athens, United States. In J Bacteriol, 2014
Previous work showed that 2AA accumulation in ridA strains of Salmonella enterica led to the inactivation of multiple target enzymes, including serine hydroxymethyltransferase (GlyA).
Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?
Wrenger et al., São Paulo, Brazil. In Biomed Res Int, 2013
The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
Folate and B12 in prostate cancer.
Collin, Bristol, United Kingdom. In Adv Clin Chem, 2012
In a meta-analysis of folate-pathway polymorphisms, MTR 2756A > G (eight studies, OR = 1.06; 95% CI 1.00, 1.12; P = 0.06) and SHMT1 1420C > T (two studies, OR = 1.11; 95% CI 1.00, 1.22; P = 0.05) were positively associated with prostate cancer risk.
Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.
Weinshilboum et al., Rochester, United States. In J Neurochem, 2012
The present study not only describes individual genetic variation that directly affects SHMT1 and SHMT2 activity, but provided insight into the overall regulation of the Folate and Methionine Cycles.
Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus.
Stover et al., United States. In J Biol Chem, 2012
SUMO and ubiquitin modification of SHMT1 occurs on the same lysine residue and determine the localization and accumulation of SHMT1 in the nucleus.
Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia.
Filipenko et al., Novosibirsk, Russia. In Bull Exp Biol Med, 2012
No statistically significant association with prostate cancer was detected for the polymorphic locus C1420T of SHMT1 gene.
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Hitre et al., Budapest, Hungary. In Pharmacogenet Genomics, 2012
The univariate and multivariate analyses demonstrated that the SHMT1 1420T allele was associated with better response (P=0.025) and longer progression-free survival (PFS) (P=0.00004) and overall survival (OS)
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.
Stover et al., Ithaca, United States. In J Biol Chem, 2012
SHMT1 and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Vitamin B6 deficiency, genome instability and cancer.
Lu et al., Kunming, China. In Asian Pac J Cancer Prev, 2011
It comprises a group of three related 3-hydroxy-2-methyl-pyrimidine derivatives: pyridoxine (PN), pyridoxal (PL), pyridoxamine (PM) and their phosphorylated derivatives [pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP)], In the folate metabolism pathway, PLP is a cofactor for the mitochondrial and cytoplasmic isozymes of serine hydroxymethyltransferase (SHMT2 and SHMT1), the P-protein of the glycine cleavage system, cystathionine β-synthase (CBS) and γ-cystathionase, and betaine hydroxymethyltransferase (BHMT), all of which contribute to homocysteine metabolism either through folate- mediated one-carbon metabolism or the transsulfuration pathway.
[Analysis of mouse strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia].
Watanabe et al., Saitama, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2010
It is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans. (review)
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