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Glycerol phosphate dehydrogenase 2, mitochondrial

Glycerolphosphate Dehydrogenase, GPDH, glycerol-3-phosphate dehydrogenase
a mitochondrial glycerol 3-phosphate dehydrogenase active in testis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, Insulin, GPD1
Papers on Glycerolphosphate Dehydrogenase
Staphylococcus epidermidis: metabolic adaptation and biofilm formation in response to different oxygen concentrations.
Uribe-Carvajal et al., Mexico. In Pathog Dis, Feb 2016
Under aerobiosis, S. epidermidis expressed high oxidoreductase activities, including glycerol-3-phosphate dehydrogenase, pyruvate dehydrogenase, ethanol dehydrogenase and succinate dehydrogenase, as well as cytochromes bo and aa3; while little tendency to form biofilms was observed.
Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants.
Nandi et al., New Delhi, India. In J Plant Res, Feb 2016
Arabidopsis thaliana glycerol-3-phosphate dehydrogenase (G3pDH), coded by SUPPRESSOR OF FATTY ACID DESATURASE 1 (SFD1; alias GLY1) gene, catalyzes the formation of glycerol 3-phosphate (G3p), the backbone of many membrane lipids.
Pathway analysis using (13) C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila.
Hilbi et al., München, Germany. In Mol Microbiol, Jan 2016
We show here that glycerol promotes intracellular replication of L. pneumophila in amoeba or macrophages (but not extracellular growth) dependent on glycerol-3-phosphate dehydrogenase, GlpD.
The enhanced lipid accumulation in oleaginous microalga by the potential continuous nitrogen-limitation (CNL) strategy.
Wang et al., Xiangtan, China. In Bioresour Technol, Jan 2016
Furthermore, the identified lipid accumulation-related metabolic checkpoints (MDH and GPDH) provide the possibilities to develop high-lipid engineering microalgae.
A nontargeted study of muscle proteome in severely obese women with androgen excess compared with severely obese men and non-hyperandrogenic women.
Escobar-Morreale et al., Madrid, Spain. In Eur J Endocrinol, Jan 2016
RESULTS: Women with hyperandrogenism presented the lowest abundances of glycogen phosphorylase, pyruvate kinase, -enolase, glycerol-3-phosphate dehydrogenase, creatine kinase M-type and desmin, whereas the abundances of these molecules were similar in control women and men.
Flavor impacts of glycerol in the processing of yeast fermented beverages: a review.
Becker et al., Freising, Germany. In J Food Sci Technol, Dec 2015
Meanwhile the yeast overexpressing GPD1 (encoding glycerol-3-phosphate dehydrogenase) produced up to 6 folds more glycerol for beer and wine.
Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels.
Jeyakumar et al., Hyderābād, India. In Biochim Biophys Acta, Dec 2015
These changes could be partly explained by the decreased activity of glycerol 3-phosphate dehydrogenase (GPDH) and the down-regulation of stearoyl CoA desaturase 1 (SCD1), both at gene and protein levels, the key determinants of triglyceride biosynthesis.
[Activity of Enzymes Involved in the Energy and Carbohydrate Metabolism and the Level of Some Molecular-Genetic Characteristics in Young Salmons (Salmo salar L.) with Different Age and Weight].
Nemova et al., In Ontogenez, Sep 2015
There was a positive correlation between the activities of cytochrome oxidase, lactate dehydrogenase, aldolase, and myosin gene expression in the muscles, cytochrome oxidase activity, glucose-6-phosphate dehydrogenase, and glycerol-3-phosphate dehydrogenase in the liver with the body weight of salmon specimens within the age groups.
Inborn errors of cytoplasmic triglyceride metabolism.
Mitchell et al., Montréal, Canada. In J Inherit Metab Dis, 2015
Two inborn errors of glycerol metabolism are known: glycerol kinase (GK, causing pseudohypertriglyceridemia) and glycerol-3-phosphate dehydrogenase (GPD1, childhood hepatic steatosis).
Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness.
Duška et al., Praha, Czech Republic. In Crit Care, 2014
We found a depletion of complex III and IV concentrations and relative increases in functional capacities of complex II and glycerol-3-phosphate dehydrogenase/complex III.
Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source.
Chen et al., Wuxi, China. In Microb Cell Fact, 2014
Glycerol kinase and glycerol-3-phosphate dehydrogenase control the first two steps of glycerol decomposition.
HypoxamiRs and cancer: from biology to targeted therapy.
Ivan et al., Sydney, Australia. In Antioxid Redox Signal, 2014
Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.
Control of gluconeogenesis by metformin: does redox trump energy charge?
Birnbaum et al., Philadelphia, United States. In Cell Metab, 2014
A new study reveals that metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase, triggering reduction of the cytosolic NADH/NAD(+) pool and impaired utilization of redox-dependent substrates for gluconeogenesis (Madiraju et al., 2014).
The role of mitochondrial function and cellular bioenergetics in ageing and disease.
Quinlan et al., Novato, United States. In Br J Dermatol, 2013
In vitro, the native rates and the relative importance of different sites both depend on the substrate being oxidized, with sites IQ, IIF, GPDH, IF and IIIQo each being important with particular substrates.
Diabetes and infections-hepatitis C: is there type 2 diabetes excess in hepatitis C infection?
Maung et al., Kuala Lumpur, Malaysia. In Curr Diab Rep, 2013
PPARα upregulates glycerol-3-phosphate dehydrogenase, glycerol kinase, and glycerol transport proteins, which allows for glucose synthesis during fasting states.
Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
Kobayashi et al., Tokushima, Japan. In Mol Genet Metab, 2011
hepatic metabolite perturbations in citrin-mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency
Glycerol-3-phosphate dehydrogenase expression and oxygen consumption in liver mitochondria of female and male rats with chronic alteration of thyroid status.
Soukup et al., Praha, Czech Republic. In Horm Metab Res, 2011
GPDH expression was significantly increased in the hyperthyroid and decreased in the hyporthyroid status in both sexes.
Role of glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation.
Shivaji et al., Hyderābād, India. In Mol Reprod Dev, 2010
GPD2 activity is required for generation of reactive oxygen species in mouse spermatozoa during capacitation, failing which, capacitation is impaired.
The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.
MacIntyre et al., Ithaca, United States. In J Hered, 2010
Gene trees for the GPDH and GPO paralogs indicate that the genes expressed in the flight muscles are evolving very slowly presumably under strong purifying selection whereas the paralogs expressed in the testes are evolving more rapidly.
The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
MacIntyre et al., Ithaca, United States. In J Hered, 2010
Molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
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