Inborn errors of cytoplasmic triglyceride metabolism.
Montréal, Canada. In J Inherit Metab Dis, 2015
Two inborn errors of glycerol metabolism are known: glycerol kinase (GK, causing pseudohypertriglyceridemia) and glycerol-3-phosphate dehydrogenase (GPD1, childhood hepatic steatosis).
HypoxamiRs and cancer: from biology to targeted therapy.
Sydney, Australia. In Antioxid Redox Signal, 2014
Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.
Control of gluconeogenesis by metformin: does redox trump energy charge?
Philadelphia, United States. In Cell Metab, 2014
A new study reveals that metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase, triggering reduction of the cytosolic NADH/NAD(+) pool and impaired utilization of redox-dependent substrates for gluconeogenesis (Madiraju et al., 2014).