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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutathione synthetase

glutathione synthetase, Glutathione Synthase
Top mentioned proteins: ACID, HAD, CAN, STEP, catalase
Papers on glutathione synthetase
Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase.
New
Ye et al., Shanghai, China. In J Ind Microbiol Biotechnol, Jan 2016
Recently, a novel bifunctional GSH synthetase was identified to be less sensitive to GSH.
Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment - Comparative proteomic study.
New
Dziedzicka-Wasylewska et al., Kraków, Poland. In Neuroscience, Jan 2016
CLO exclusively up-regulated proteins involved in neuroprotection, such as glutathione synthetase, heat-shock 70-kDa protein 8 and mitochondrial heat-shock protein 75.
Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.
New
Mungan et al., In J Pediatr Endocrinol Metab, Jan 2016
BACKGROUND: Glutathione synthetase (GS) deficiency is a rare inborn error of glutathione (GSH) metabolism manifested by severe metabolic acidosis, hemolytic anemia, neurological problems and massive excretion of pyroglutamic acid (5-oxoproline) in the urine.
[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].
Review
New
Kullak-Ublick et al., Innsbruck, Austria. In Ther Umsch, Dec 2015
The etiology seems to be a drug-induced reversible inhibition of glutathione synthetase or 5-oxoprolinase leading to elevated serum and urine levels of 5-oxoproline.
Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production.
New
Ye et al., Shanghai, China. In J Biotechnol, Dec 2015
In this study, four different vector systems, pET28a, pUC18, pUC19-P32, and pUC19-Pabb, were applied for expression of gshF, encoding the bifunctional glutathione synthetase of Streptococcus thermophiles.
Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA.
New
Pan et al., Wenzhou, China. In Chemosphere, Nov 2015
The altered factors include AKT-1, DAF-16, glutathione synthetase (GSS-1), glutathione S-transferase-24 (GST-24), mitogen-activated protein kinase kinase-4 (MKK-4), multidrug resistance-associated protein-1 (MRP-1), and pyruvate dehydrogenase kinase-2 (PDHK-2) (P<0.05).
Genes related to antioxidant metabolism are involved in Methylobacterium mesophilicum-soybean interaction.
New
Dourado et al., São Paulo, Brazil. In Antonie Van Leeuwenhoek, Oct 2015
Further evaluation of stress- and methylotrophic-related genes expression by qPCR showed that glutathione peroxidase and glutathione synthetase genes were up-regulated during the Methylobacterium-soybean interaction.
Cultivating the uncultured: growing the recalcitrant cluster-2 Frankia strains.
Boudabous et al., Tunisia. In Sci Rep, 2014
Analysis of the draft genome confirmed its close proximity to the Candidatus Frankia datiscae Dg1 genome with the absence of 38 genes (trehalose synthase, fumarylacetoacetase, etc) in BMG5.1 and the presence of 77 other genes (CRISPR, lanthionine synthase, glutathione synthetase, catalase, Na+/H+ antiporter, etc) not found in Dg1.
Three-pathway combination for glutathione biosynthesis in Saccharomyces cerevisiae.
Wang et al., Beijing, China. In Microb Cell Fact, 2014
BACKGROUND: Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (Gsh1 or GshA) and glutathione synthetase (Gsh2 or GshB); (2) a bifunctional γ-glutamylcysteine synthetase/glutathione synthetase (GshF); (3) an alternative condensation of γ-glutamyl phosphate synthesized by γ-glutamyl kinase (Pro1 or ProB) with cysteine to form γ-glutamylcysteine which was further conjugated to glycine by glutathione synthetase.
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Review
Mullins et al., Saint Louis, United States. In Clin Toxicol (phila), 2013
When HAGMA is diagnosed, the 5-oxoproline concentration and the glutathione synthetase activity should be measured.
Thiol-based redox signaling in the nitrogen-fixing symbiosis.
Review
Becana et al., Nice, France. In Front Plant Sci, 2012
A combination of enzymatic, immunological, pharmacological and molecular analyses has allowed us to conclude that glutathione and its legume-specific homolog, homoglutathione, are abundant in meristematic and infected cells, that their spatio-temporally distribution is correlated with the corresponding (homo)glutathione synthetase activities, and that they are crucial for nodule development and function.
Glutathione synthesis and its role in redox signaling.
Review
Forman et al., Los Angeles, United States. In Semin Cell Dev Biol, 2012
It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change.
The role of glutathione in brain tumor drug resistance.
Review
Reigan et al., Aurora, United States. In Biochem Pharmacol, 2012
Glutamate cysteine ligase (GCL), glutathione synthetase (GS), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferases (GST), and GSH complex export transporters (GS-X pumps) are major components of the GSH-dependent enzyme system that function in a dynamic cascade to maintain redox homeostasis.
Mutations in the glutathione synthetase gene cause 5-oxoprolinuria.
Impact
Lieberman et al., Houston, United States. In Nat Genet, 1996
5-Oxoprolinuria (pyroglutamic aciduria) resulting from glutathione synthetase (GSS) deficiency is an inherited autosomal recessive disorder characterized, in its severe form, by massive urinary excretion of 5-oxoproline, metabolic acidosis, haemolytic anaemia and central nervous system damage.
Protection of granulocytes by vitamin E in glutathione synthetase deficiency.
Impact
Schulman et al., In N Engl J Med, 1979
The administration of vitamin E (alpha-tocopherol) was found to improve polymorphonuclear leukocyte function in an infant with congenital deficiency of glutathione synthetase activity.
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