Global profiling of the signaling network of papillary thyroid carcinoma.
New York City, United States. In Life Sci, Feb 2016
KEY FINDINGS: 11 were differentially expressed between tumors and surrounding tissues, 8 of which were up-regulated (cytokeratin 18, Stat 1, HMG-1, p-p70 S6 kinase, Raf-B, glutamine synthetase, p-PKC δ, and HDAC1), while 3 of which were down-regulated (cytokeratin 5, BECN1, and p-ERK).
Current concepts in the immunohistochemical evaluation of liver tumors.
New York City, United States. In World J Hepatol, Jul 2015
Recent advances have established a classification system for hepatocellular adenomas (HCAs) based on morphology, molecular alterations, and immunohistochemistry. Specifically, loss of liver fatty acid binding protein is seen in HNF1α-inactivated HCA, staining with serum amyloid A is seen in inflammatory HCA, and diffuse staining with glutamine synthetase (GS) is seen in β-catenin activated HCA.
An overview of biological production of L-theanine.
Wuxi, China. In Biotechnol Adv, May 2015
Four kinds of bacterial enzymes, including L-glutamine synthetase, γ-glutamylmethylamide synthetase, γ-glutamyltranspeptidase, and L-glutaminase, have been characterized to have L-theanine-producing ability.
Role of astrocytes in epilepsy.
Bonn, Germany. In Cold Spring Harb Perspect Med, Mar 2015
In addition, malfunction of glutamate transporters and the astrocytic glutamate-converting enzyme, glutamine synthetase, has been observed in epileptic tissue.
A current review for biological monitoring of manganese with exposure, susceptibility, and response biomarkers.
Seoul, South Korea. In J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2014
In this study, we review current statuses of Mn exposure via various exposure routes including food, high susceptible population, effects of genetic polymorphisms of metabolic enzymes or transporters (CYP2D6, PARK9, SLC30A10, etc.), alterations of the Mn-responsive proteins (i.e., glutamine synthetase, Mn-SOD, metallothioneins, and divalent metal trnsporter1), and epigenetic changes due to the Mn exposure.