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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate-ammonia ligase

glutamine synthetase, Glutamate-Ammonia Ligase
Top mentioned proteins: ACID, CAN, HAD, V1a, Glial Fibrillary Acidic Protein
Papers using glutamine synthetase antibodies
Auxin biosynthesis and its role in plant development
Supplier
Kirby Edward G. et al., In Journal of Experimental Botany, 2009
... Transgenic lines with ectopic expression of pine glutamine synthetase GS1a (Gallardo et al., 1999) and non-transgenic controls were grown in ...
Papers on glutamine synthetase
Glutamate and histidine improve both solvent yields and the acid tolerance response of Clostridium beijerinckii NCP 260.
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Reid et al., Cape Town, South Africa. In J Appl Microbiol, Feb 2016
Using quantitative PCR, the transcription of the glutamine synthetase, nitrogen regulator and glutamate synthase operon (glnA-nitR-gltAB) was monitored during acid shock conditions, and expression of both the nitR and gltA genes was shown to be increased two-fold.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
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Kakar et al., San Francisco, United States. In Mod Pathol, Feb 2016
This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting.
Global profiling of the signaling network of papillary thyroid carcinoma.
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Zhang et al., New York City, United States. In Life Sci, Feb 2016
KEY FINDINGS: 11 were differentially expressed between tumors and surrounding tissues, 8 of which were up-regulated (cytokeratin 18, Stat 1, HMG-1, p-p70 S6 kinase, Raf-B, glutamine synthetase, p-PKC δ, and HDAC1), while 3 of which were down-regulated (cytokeratin 5, BECN1, and p-ERK).
Negative impact of AQP-4 channel inhibition on survival of retinal ganglion cells and glutamate metabolism after crushing optic nerve.
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Ikeda et al., Ōsaka, Japan. In Exp Eye Res, Feb 2016
The expressions of glutamine synthetase, glutamate-aspartate transporter (GLAST), and AQP4 were determined on day 3 by immunoblotting.
Effect of Liver Damage and Hyperbaric Oxygenation on Glutamine Synthetase of Hepatocytes.
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Yakovlev et al., Voronezh, Russia. In Bull Exp Biol Med, Jan 2016
Activity of glutamine synthetase in the hepatocytes of healthy animals and animals with chronic CCl4-induced hepatitis was studied on white mature female rats after liver resection (15-20% of organ weight) and hyperbaric oxygenation (3 atm, 50 min, 3 times).
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.
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Impact
Zong et al., Stony Brook, United States. In Cell Metab, Jan 2016
Here we report that in a number of human and murine cells and cancers, Myc induces elevated expression of glutamate-ammonia ligase (GLUL), also termed glutamine synthetase (GS), which catalyzes the de novo synthesis of glutamine from glutamate and ammonia.
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
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Impact
Gottlieb et al., Luxembourg, Luxembourg. In Nat Cell Biol, Dec 2015
Instead, the conversion of Glu to Gln by glutamine synthetase (GS; cataplerosis) confers Gln prototrophy, and fuels de novo purine biosynthesis.
Current concepts in the immunohistochemical evaluation of liver tumors.
Review
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Lagana et al., New York City, United States. In World J Hepatol, Jul 2015
Recent advances have established a classification system for hepatocellular adenomas (HCAs) based on morphology, molecular alterations, and immunohistochemistry. Specifically, loss of liver fatty acid binding protein is seen in HNF1α-inactivated HCA, staining with serum amyloid A is seen in inflammatory HCA, and diffuse staining with glutamine synthetase (GS) is seen in β-catenin activated HCA.
An overview of biological production of L-theanine.
Review
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Jiang et al., Wuxi, China. In Biotechnol Adv, May 2015
Four kinds of bacterial enzymes, including L-glutamine synthetase, γ-glutamylmethylamide synthetase, γ-glutamyltranspeptidase, and L-glutaminase, have been characterized to have L-theanine-producing ability.
Role of astrocytes in epilepsy.
Review
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Steinhäuser et al., Bonn, Germany. In Cold Spring Harb Perspect Med, Mar 2015
In addition, malfunction of glutamate transporters and the astrocytic glutamate-converting enzyme, glutamine synthetase, has been observed in epileptic tissue.
Excretion of cytosolic proteins (ECP) in bacteria.
Review
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Ebner et al., Tübingen, Germany. In Int J Med Microbiol, Feb 2015
When microbiologists first began to study this subject in 1990, mainly singular cytoplasmic proteins were investigated, such as GAPDH at the cell surface and in the supernatant of pathogenic streptococci or glutamine synthetase (GlnA) as a major extracellular protein in pathogenic mycobacteria.
A current review for biological monitoring of manganese with exposure, susceptibility, and response biomarkers.
Review
Yang et al., Seoul, South Korea. In J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2014
In this study, we review current statuses of Mn exposure via various exposure routes including food, high susceptible population, effects of genetic polymorphisms of metabolic enzymes or transporters (CYP2D6, PARK9, SLC30A10, etc.), alterations of the Mn-responsive proteins (i.e., glutamine synthetase, Mn-SOD, metallothioneins, and divalent metal trnsporter1), and epigenetic changes due to the Mn exposure.
FOXOphagy path to inducing stress resistance and cell survival.
Impact
Sandri, In Nat Cell Biol, 2012
A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
Impact
Coffer et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
Using this pathway approach, we identified glutamine synthetase as being transcriptionally regulated by PI(3)K-PKB-FOXO signalling.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Impact
Bishop et al., San Francisco, United States. In Cell Metab, 2012
Increased glutamine catabolism in MYC-induced liver tumors is associated with decreased levels of glutamine synthetase (Glul) and the switch from Gls2 to Gls1 glutaminase.
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