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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 May 2015.

Glutaminase

Glutaminase, LGA
catalyzes the conversion of L-glutamine and H2O to L-glutamate and NH3 in glutamine catabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, AGE
Papers on Glutaminase
Viral protein R of human immunodeficiency virus type-1 induces retrotransposition and upregulates glutamate synthesis by the signal transducer and activator of transcription 1 signaling pathway.
New
Ishizaka et al., Tokyo, Japan. In Microbiol Immunol, 20 Jun 2015
Moreover, rVpr increased production of glutaminase C, a regulator of glutamate synthesis, which was also dependent on the cGAS-STING pathway.
Effect of dietary protein restriction on renal ammonia metabolism.
New
Weiner et al., China. In Am J Physiol Renal Physiol, 29 May 2015
The expression of multiple proteins involved in renal ammonia metabolism was altered, including the ammonia generating enzymes, phosphate-dependent glutaminase (PDG) and phosphoenolpyruvate-carboxykinase (PEPCK), and the ammonia metabolizing enzyme, glutamine synthetase.
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
New
Dang et al., In J Clin Invest, 27 May 2015
UNASSIGNED: Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation.
Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines.
New
Mittelman et al., Los Angeles, United States. In Leuk Res, 22 May 2015
To evaluate the importance of glutaminase activity, we exploited a recently developed mutant of Helicobacter pylori ASNase (dm HpA), with amino acid substitutions M121C/T169M.
An overview of biological production of L-theanine.
Review
New
Jiang et al., Wuxi, China. In Biotechnol Adv, 11 May 2015
Four kinds of bacterial enzymes, including L-glutamine synthetase, γ-glutamylmethylamide synthetase, γ-glutamyltranspeptidase, and L-glutaminase, have been characterized to have L-theanine-producing ability.
The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.
Review
New
Sweet et al., Morgantown, United States. In Ann N Y Acad Sci, Mar 2015
Studies of the glutamate metabolic pathway have been limited, although there is some evidence that excitatory amino acid transporter-2, glutamine synthetase, and glutaminase have altered expression in schizophrenia.
Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
Review
New
Jalan et al., Sevilla, Spain. In J Hepatol, Feb 2015
The exact pathophysiological mechanisms of HE in this group of patients are unclear but hyperammonemia, systemic inflammation (including sepsis, bacterial translocation, and insulin resistance) and oxidative stress, modulated by glutaminase gene alteration, remain as key factors.
PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins.
Review
New
Banerjee et al., Stillwater, United States. In Biology (basel), Dec 2014
Human Tax-interacting protein 1 (TIP-1), also known as glutaminase interaction protein (GIP), is a Class I PDZ domain protein that recognizes the consensus binding motif X-S/T-X-V/I/L-COOH of the C-terminus of its target proteins.
pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function.
Review
New
Gstraunthaler et al., Innsbruck, Austria. In Am J Physiol Renal Physiol, Aug 2014
LLC-PK1-FBPase(+) cells grow in the absence of hexoses and pentoses and exhibit enhanced oxidative metabolism and increased levels of phosphate-dependent glutaminase.
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
Impact
Iliopoulos et al., United States. In Cell Metab, 2013
Lastly, HIF rendered VHL-deficient cells sensitive to glutamine deprivation in vitro, and systemic administration of glutaminase inhibitors suppressed the growth of RCC cells as mice xenografts.
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
GeneRIF
Sivaraman et al., Singapore, Singapore. In Proc Natl Acad Sci U S A, 2012
KGA activity in cells is stimulated by EGF, and KGA associates with all three kinase components of the Raf-1/Mek2/Erk signaling module.
Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation.
GeneRIF
Rayport et al., New York City, United States. In Hippocampus, 2012
In wild-type (WT) mice, GLS1 gene expression was highest in the hippocampus and cortex, where it was reduced by about 50% in Glutaminase-deficient mice.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Impact
GeneRIF
Bishop et al., San Francisco, United States. In Cell Metab, 2012
Inhibition of Gls1 kills lung cancer cells that overexpress MYC and catabolize glutamine.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Impact
Dang et al., Baltimore, United States. In Cell Metab, 2012
The essential role of glutamine metabolism in cell survival and proliferation under hypoxia and glucose deficiency makes them susceptible to the glutaminase inhibitor BPTES and hence could be targeted for cancer therapy.
Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders.
GeneRIF
Zheng et al., Omaha, United States. In Plos One, 2011
Data indicate that both HIV-1 infection and IFN-alpha treatment increase glutaminase 1 (GLS1) expression through STAT1 phosphorylation and by binding to the GLS1 promoter.
Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism.
GeneRIF
Márquez et al., Málaga, Spain. In Plos One, 2011
Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
Impact
Cerione et al., Ithaca, United States. In Cancer Cell, 2010
We identify the target of this inhibitor to be the metabolic enzyme glutaminase, which catalyzes the hydrolysis of glutamine to glutamate.
Brain glutaminases.
Alonso et al., In Biomol Concepts, 2010
Glutaminase is considered as the main glutamate producer enzyme in brain.
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Impact
GeneRIF
Dang et al., Baltimore, United States. In Nature, 2009
c-Myc transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells
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