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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Dec 2014.

Glutaminase

Glutaminase, LGA
catalyzes the conversion of L-glutamine and H2O to L-glutamate and NH3 in glutamine catabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, AGE
Papers on Glutaminase
Proline metabolism and cancer: emerging links to glutamine and collagen.
New
Fischer et al., Frederick, United States. In Curr Opin Clin Nutr Metab Care, 31 Jan 2015
Although the interconvertibility of proline and glutamine has been long established, recent findings showed that the proto-oncogene, cellular myelocytomatosis oncogene, upregulates glutamine utilization (glutaminase) and routes glutamate to proline biosynthesis (pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate reductases).
Impact of singlehood during pregnancy on dietary intake and birth outcomes- a study in the Norwegian Mother and Child Cohort Study.
New
Brantsæter et al., In Bmc Pregnancy Childbirth, 05 Jan 2015
We used nonparametric tests to compare dietary intakes by marital status, and multiple logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for infants being small for gestational age (SGA), large for gestational age (LGA), and preterm delivery (defined as delivery before gestational week 37).ResultsSingle women living with parents had lower intakes of fruits and vegetables, higher intake of total energy, higher proportion of energy from added sugar, and lower intake of fibre than the reference group.
Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer.
New
Qian et al., Wuhan, China. In Biochem Biophys Res Commun, 04 Jan 2015
Glutaminase (GLS1) is a key enzyme that converts glutamine to glutamate.
Glutaminase1 heterozygous mice show enhanced trace fear conditioning and Arc/Arg3.1 expression in hippocampus and cingulate cortex.
New
Gaisler-Salomon et al., Haifa, Israel. In Eur Neuropsychopharmacol, 31 Dec 2014
Mice heterozygous for a mutation in the glutaminase (GLS1) gene (GLS1 HZ mice), with reduced glutamate recycling and release, display reduced hippocampal function as well as memory of contextual cues in a delay fear conditioning (FC) paradigm.
Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period.
New
Gammie et al., Madison, United States. In Brain Res, 23 Nov 2014
In postpartum females (relative to virgins), tissue levels of glutamate and GABA were elevated in LS and increased mRNA was found for the respective enzymes producing glutamate and GABA, glutaminase (Gls) and glutamate decarboxylase 1 and 2 (Gad1 and Gad2).
Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute on chronic liver failure.
Review
New
Jalan et al., Sevilla, Spain. In J Hepatol, Oct 2014
The exact pathophysiological mechanisms of HE in this group of patients are unclear but hyperammonemia, systemic inflammation (including sepsis, bacterial translocation and insulin resistance) and oxidative stress modulated by glutaminase gene alteration remain as key factors.
pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function.
Review
New
Gstraunthaler et al., Innsbruck, Austria. In Am J Physiol Renal Physiol, Aug 2014
LLC-PK1-FBPase(+) cells grow in the absence of hexoses and pentoses and exhibit enhanced oxidative metabolism and increased levels of phosphate-dependent glutaminase.
Asparaginase in the treatment of non-ALL hematologic malignancies.
Review
New
Sausville et al., Baltimore, United States. In Cancer Chemother Pharmacol, May 2014
Indeed, both Escherichia coli and Erwinia chrysanthemi asparaginases possess glutaminase enzymatic activity, and their administrations have shown to reduce serum glutamine level by deamidating glutamine to glutamate and ammonia.
Actinobacteriological research in India.
Review
New
Kamat et al., Taleigao, India. In Indian J Exp Biol, Aug 2013
Research on enzymes mostly covered lipases, amylases, proteases, endoglucanases, a-galactosidases, pectin lyases, xylanases, L-asparaginases, L-glutaminase and cellulases.
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
New
Impact
Iliopoulos et al., United States. In Cell Metab, Apr 2013
Lastly, HIF rendered VHL-deficient cells sensitive to glutamine deprivation in vitro, and systemic administration of glutaminase inhibitors suppressed the growth of RCC cells as mice xenografts.
Cancer cell metabolism: implications for therapeutic targets.
Review
Lee et al., Seoul, South Korea. In Exp Mol Med, 2012
In this review, we will discuss dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as hexokinase, phosphofructokinase, pyruvate kinase M2, lactate dehydrogenase, pyruvate dehydrogenase kinase and glutaminase.
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
GeneRIF
Sivaraman et al., Singapore, Singapore. In Proc Natl Acad Sci U S A, 2012
KGA activity in cells is stimulated by EGF, and KGA associates with all three kinase components of the Raf-1/Mek2/Erk signaling module.
Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation.
GeneRIF
Rayport et al., New York City, United States. In Hippocampus, 2012
In wild-type (WT) mice, GLS1 gene expression was highest in the hippocampus and cortex, where it was reduced by about 50% in Glutaminase-deficient mice.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Impact
GeneRIF
Bishop et al., San Francisco, United States. In Cell Metab, 2012
Inhibition of Gls1 kills lung cancer cells that overexpress MYC and catabolize glutamine.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Impact
Dang et al., Baltimore, United States. In Cell Metab, 2012
The essential role of glutamine metabolism in cell survival and proliferation under hypoxia and glucose deficiency makes them susceptible to the glutaminase inhibitor BPTES and hence could be targeted for cancer therapy.
Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders.
GeneRIF
Zheng et al., Omaha, United States. In Plos One, 2011
Data indicate that both HIV-1 infection and IFN-alpha treatment increase glutaminase 1 (GLS1) expression through STAT1 phosphorylation and by binding to the GLS1 promoter.
Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism.
GeneRIF
Márquez et al., Málaga, Spain. In Plos One, 2011
Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
Impact
Cerione et al., Ithaca, United States. In Cancer Cell, 2010
We identify the target of this inhibitor to be the metabolic enzyme glutaminase, which catalyzes the hydrolysis of glutamine to glutamate.
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Impact
GeneRIF
Dang et al., Baltimore, United States. In Nature, 2009
c-Myc transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells
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