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Glutamic pyruvate transaminase

glutamic-pyruvic transaminase, ALT2, GPT2
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, AGE, Serum albumin
Papers on glutamic-pyruvic transaminase
Development of monoclonal antibodies and immunochromatographic lateral flow device for rapid test of alanine aminotransferase isoenzyme 1.
New
Zhang et al., Chongqing, China. In Protein Expr Purif, Mar 2016
But measurement of ALT isoenzymes, ALT1 and ALT2, was reported to be of more diagnostic value.
Antioxidant and Hepatoprotective Activities of Mycelia Selenium Polysaccharide by Hypsizigus marmoreus SK-02.
New
Jia et al., China. In Biol Trace Elem Res, Feb 2016
The treatment of MSPS for CCl4-induced animal experiment demonstrated that the MSPS could reduce the levels of malondiadehyde (MDA), lipid peroxide (LPO), glutamic oxalacetic transaminase (AST), and glutamic-pyruvic transaminase (ALT) activities and improve the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), total cholesterol (TC), and triglyceride (TG) in serum/liver homogenate against CCl4-induced injures.
Ultrafast Singlet Fission in a Push-Pull Low-Bandgap Polymer Film.
New
Ito et al., Kyoto, Japan. In J Am Chem Soc, Jan 2016
Excited-state dynamics in poly[4,6-(dodecyl-thieno[3,4-b]thiophene-2-carboxylate)-alt-2,6-(4,8-dioctoxylbenzo[1,2-b:4,5-b]dithiophene)] (PTB1) was studied by transient absorption spectroscopy.
High-Efficiency Polymer LEDs with Fast Response Times Fabricated via Selection of Electron-Injecting Conjugated Polyelectrolyte Backbone Structure.
New
Kim et al., Taejŏn, South Korea. In Acs Appl Mater Interfaces, Jan 2016
Imidazolium ionic side-group-containing fluorene-based conjugated polyelectrolytes (CPEs) with different π-conjugated structures, poly[(9,9-bis(8'-(3″-methyl-1″-imidazolium)octyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)] dibromide (F8im-Br) and poly[(9,9-bis(8'-(3″-methyl-1″-imidazolium)octyl)-2,7-fluorene)-alt-(benzo(2,1,3)thiadiazol-4,8-diyl) dibromide (F8imBT-Br), are synthesized and utilized as an electron injection layer (EIL) in green-emitting F8BT polymer light-emitting diodes (PLEDs).
Circulating mitochondrial biomarkers for drug-induced liver injury.
New
Beger et al., United States. In Biomark Med, Nov 2015
The tissue specificity of ALT was improved by differentiating cytosolic ALT1 and mitochondrial ALT2 isoforms released in circulation.
Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo.
New
Datta et al., Delhi, India. In Int J Obes (lond), Nov 2015
Serum levels of cholesterol, triglyceride and serum glutamic oxaloacetic transaminase/serum glutamic-pyruvic transaminase (SGOT/SGPT) were evaluated.
Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness.
New
Fulda et al., Italy. In Sleep Med, Oct 2015
RESULTS: Despite a high correlation between methods, only the Alt2 algorithm provided significantly different results, with PLMS/PLMW indices being consistently lower than those provided by the other two methods.
Methods to Estimate V˙O2max upon Acute Hypoxia Exposure.
Review
New
Lohse et al., Vancouver, Canada. In Med Sci Sports Exerc, Sep 2015
The final model included altitude, baseline V˙O2max, Alt2, baseline V˙O2max2, and the interaction of altitude with baseline V˙O2max.
Psychological and physiological correlates of childhood obesity in Taiwan.
Chen et al., Taipei, Taiwan. In Sci Rep, 2014
We found that regarding physiological characteristics, compared with the healthy-weight children, the overweight/obese children had significantly higher values for body fat estimated using the bioelectrical impedance method (p < 0.001), systolic blood pressure (p < 0.001), and diastolic blood pressure (p = 0.001); lower values for high-density lipoprotein (p < 0.001); and worse values for glutamic-pyruvic transaminase (p < 0.001), triglycerides (p < 0.001), and fasting blood glucose (p = 0.049).
The role of plastidial glucose-6-phosphate/phosphate translocators in vegetative tissues of Arabidopsis thaliana mutants impaired in starch biosynthesis.
GeneRIF
Schneider et al., Köln, Germany. In Plant Biol (stuttg), 2010
GPT2 contributes significantly to the measurable Glc6P transport activity in leaves of mutants impaired in starch biosynthesis. A knockout of GPT2 in the background of adg1-1 additionally impairs growth under short-day conditions.
Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia.
Impact
Berlin-Frankfurt-Münster group et al., Gießen, Germany. In J Clin Oncol, 2010
National Cancer Institute Common Toxicity Criteria 3/4 toxicities attributable to rituximab were general condition, 15%; fatigue, 13%; anaphylaxis, 7%; infection, 3%; glutamic-oxaloacetic transaminase/glutamic-pyruvic transaminase, 8%; no capillary leakage; and no toxic death.
Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma.
GeneRIF
Cotgreave et al., Södertälje, Sweden. In Int J Mol Med, 2009
A clinical method for selective measurement of ALT1 and 2 in human plasma is described.
A comparison of associations of alanine aminotransferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes.
GeneRIF
Lawlor et al., Bristol, United Kingdom. In Hepatology, 2007
Elevation of liver enzymes and hepatic insulin resistance as reflected by fasting insulin occur in the early stages of insulin resistance and highlight the central role of the liver in insulin resistance in the general population.
Alterations of biliary biochemical constituents and cytokines in infantile hepatitis syndrome.
GeneRIF
Zhang et al., Wuhan, China. In World J Gastroenterol, 2006
The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase.
GeneRIF
Gong et al., Baltimore, United States. In Genomics, 2002
expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis.
[Acute hepatitis A (HA) presenting findings of meningoencephalitis].
Review
Shinohara et al., Funaishikawa, Japan. In Rinsho Shinkeigaku, 1992
Laboratory test results included the following: GOT 1,740 U/l, GPT 2,800 U/l, bilirubin 1.2 mg/dl, serum IgM-HA antibody cut-off index 6.8.
Bioactivity of neolignans from fructus Schizandrae.
Review
Li, Matera, Italy. In Mem Inst Oswaldo Cruz, 1990
Fructus Schizandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis.
[Clinical efficacy of ceftriaxone administered once daily against pyelonephritis].
Review
Nagata et al., Hiratsuka, Japan. In Hinyokika Kiyo, 1989
No abnormal values were observed in any cases except for a slight increase in glutamic-pyruvic transaminase and alkaline phosphatase in one case and skin rash in another case which appeared following the initial dose and required the immediate withdrawal of the drug.
Mediterranean spotted fever: a cooperative study of 227 cases.
Review
Segura-Porta et al., In Rev Infect Dis, 1985
Hepatic function tests (serum glutamic-pyruvic transaminase, serum glutamic-oxaloacetic transaminase) gave abnormal results in 55% of all cases.
Polymorphism of soluble glutamic-pyruvic transaminase: a new genetic marker in man.
Impact
Giblett et al., In Science, 1971
Soluble glutamic-pyruvic transaminase (GPT) has three common phenotypes, each representing the homozygous and heterozygous expression of two alleles, Gpt(1) and Gpt(2) at an autosomal locus.
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