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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate dehydrogenase 1b

Glutamate Dehydrogenase
Top mentioned proteins: ACID, CAN, HAD, V1a, STEP
Papers on Glutamate Dehydrogenase
Multilocus genotyping of Giardia duodenalis and Enterocytozoon bieneusi in dairy and native beef (Qinchuan) calves in Shaanxi province, northwestern China.
New
Zhao et al., China. In Parasitol Res, Feb 2016
Seventeen, eight, five, and two G. duodenalis subtypes were detected at the triose phosphate isomerase (tpi), β-giardin (bg), glutamate dehydrogenase (gdh), and small subunit ribosomal RNA (SSU-rRNA) loci, with five and two novel subtypes detected at the tpi and bg loci, forming 25 multiple genotypes (MLGs) (15 and 11 in dairy and Qinchuan calves, respectively).
Prevalence, Risk Factors and Multilocus Genotyping of Giardia intestinalis in Dairy Cattle, Northwest China.
New
Zhu et al., Lanzhou, China. In J Eukaryot Microbiol, Feb 2016
Intra-variations were also detected at tpi, glutamate dehydrogenase (gdh) and beta giardin (bg) loci within assemblage E, showing seven, three and five new subtypes, respectively.
Calcium regulates glutamate dehydrogenase and poly-γ-glutamic acid synthesis in Bacillus natto.
New
Chen et al., Xi'an, China. In Biotechnol Lett, Jan 2016
OBJECTIVE: To study the effect of Ca(2+) on glutamate dehydrogenase (GDH) and its role in poly-γ-glutamic acid (γ-PGA) synthesis in Bacillus natto HSF 1410.
Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells.
Review
New
Lammert et al., Düsseldorf, Germany. In Trends Endocrinol Metab, Jan 2016
Mitochondrial degradation of glutamate also contributes to insulin release when glutamate dehydrogenase is allosterically activated.
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.
New
Wang et al., Tainan City, Taiwan. In Plos One, Dec 2015
At the same time, we observed an increase in the activity of the two enzymes that convert glutamate to α-KG, glutamate dehydrogenase (GDH) and aspartate aminotransferase (ASAT).
Molecular mechanisms of congenital hyperinsulinism.
Review
New
Hussain et al., London, United Kingdom. In J Mol Endocrinol, Apr 2015
Mutations in GLUD1 and HADH lead to leucine-induced HH, and these two genes encode the key enzymes glutamate dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase which play a key role in amino acid and fatty acid regulation of insulin secretion respectively.
Diagnostic pitfalls in Clostridium difficile infection.
Review
New
Wilcox et al., Leeds, United Kingdom. In Infect Dis Clin North Am, Mar 2015
Rapid commercial assays, including nucleic acid amplification tests and immunoassays for C difficile toxin and glutamate dehydrogenase, have largely superseded the use of older assays.
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
New
Impact
Kang et al., Atlanta, United States. In Cancer Cell, Mar 2015
Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated in human cancers.
Comparison of a novel chemiluminescent based algorithm to three algorithmic approaches for the laboratory diagnosis of Clostridium difficile infection.
Mégraud et al., Bordeaux, France. In Gut Pathog, 2014
They are included in a two-step algorithm diagnosis, including first the detection of the glutamate dehydrogenase (GDH) as a screening method and second the detection of toxins as a confirmatory method.
Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia.
Review
Hussain et al., Singapore, Singapore. In World J Diabetes, 2014
The observation of protein induced hypoglycaemia in patients with mutations in GLUD1 gene, encoding the enzyme glutamate dehydrogenase (GDH) and HADH gene, encoding for the enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase has provided new mechanistic insights into the regulation of insulin secretion by amino acid and fatty acid metabolism.
Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells.
Review
Kim et al., Seoul, South Korea. In J Cancer Prev, 2013
The tumor suppressor SIRT4 inhibits glutamate dehydrogenase, which converts glutamic acid to α-ketoglutarate, an intermediate in the TCA cycle.
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
Impact
Blenis et al., Boston, United States. In Cell, 2013
Here, we show that mTORC1 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH).
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Impact
Kimmelman et al., Boston, United States. In Nature, 2013
Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-derived glutamate into α-ketoglutarate in the mitochondria to fuel the tricarboxylic acid cycle, PDAC relies on a distinct pathway in which glutamine-derived aspartate is transported into the cytoplasm where it can be converted into oxaloacetate by aspartate transaminase (GOT1).
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Impact
Simon et al., Philadelphia, United States. In Cancer Cell, 2012
MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis.
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Impact
Guarente et al., Cambridge, United States. In Cell, 2006
We show that SIRT4 is a mitochondrial enzyme that uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH) activity.
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