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Glutamate decarboxylase 2

Glutamate Decarboxylase, GAD65
catalyzes synthesis of gamma-Aminobutyric acid (GABA), the most widely distributed inhibitory neurotransmitter [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Rdl, Glutamate Decarboxylase, CAN, HAD
Papers using Glutamate Decarboxylase antibodies
GABA-A receptors: a viable target for novel anxiolytics?
Supplier
Capogna Marco et al., In Frontiers in Neural Circuits, 2005
... Acute coronal slices were prepared from 2 to 3 weeks-old glutamate decarboxylase 65 (GAD65)-GFP transgenic mice (Lopez-Bendito et al., ...
Papers on Glutamate Decarboxylase
Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up.
New
Zhou et al., Changsha, China. In Diabetes Metab Res Rev, Feb 2016
This study aimed to investigate the persistent status of glutamic acid decarboxylase antibody (GADA) in patients with LADA and its association with clinical characteristics.
Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95).
New
Wu et al., Taipei, Taiwan. In Mol Neurobiol, Feb 2016
Previously, we reported the effect of phosphorylation on the two well-defined GAD isoforms, namely, GAD65 and GAD67, using highly purified preparations of recombinant human brain GAD65 (hGAD65) and GAD67.
Dual projections of single orexin- or CART-immunoreactive, lateral hypothalamic neurons to the paraventricular thalamic nucleus and nucleus accumbens shell in the rat: Light microscopic study.
New
Lee et al., Seoul, South Korea. In Brain Res, Feb 2016
At the light microscopic level, ORX (or CART) terminals formed close appositions to choline acetyltransferase (ChAT)-, glutamate decarboxylase (GAD)-, or enkephalin (Enk)-immunoreactive neuronal elements in the AcbSh.
Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
New
Better Diabetes Diagnosis (BDD) Study Group et al., Malmö, Sweden. In Diabetes, Feb 2016
UNASSIGNED: The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear.
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.
Review
New
Pugliese et al., Miami, United States. In Curr Diab Rep, Dec 2015
T1DR is typically characterized by (1) variable degree of insulitis and loss of insulin staining, on pancreas transplant biopsy (with most often absent), minimal to moderate and rarely severe pancreas, and/or kidney transplant rejection; (2) the conversion of T1D-associated autoantibodies (to the autoantigens GAD65, IA-2, and ZnT8), preceding hyperglycemia by a variable length of time; and (3) the presence of autoreactive T cells in the peripheral blood, pancreas transplant, and/or peripancreatic transplant lymph nodes.
Oral Administration of Silkworm-Produced GAD65 and Insulin Bi-Autoantigens against Type 1 Diabetes.
New
Jin et al., Hangzhou, China. In Plos One, Dec 2015
In this study, we generated a fusion protein CTB-Ins-GAD composed of CTB (cholera toxin B subunit), insulin, and three copies of GAD65 peptide 531-545, which were efficiently produced in silkworm pupae, to evaluate its protective effect against T1D.
Mechanisms of acid tolerance in bacteria and prospects in biotechnology and bioremediation.
Review
New
Xu et al., Shanghai, China. In Biotechnol Adv, Dec 2015
Common mechanisms for acid resistance in bacteria are proton pumping by F1-F0-ATPase, the glutamate decarboxylase system, formation of a protective cloud of ammonia, high cytoplasmic urease activity, repair or protection of macromolecules, and biofilm formation.
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.
Review
New
Wang et al., Toronto, Canada. In Autoimmun Rev, Nov 2015
Autoimmunity against glutamic acid decarboxylase 65 (GAD65; synthesizes GABA) occurs in T1D.
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.
New
Impact
Ding et al., Palo Alto, United States. In Science, Nov 2015
Here, we show that GABA co-release in dopamine neurons does not use the conventional GABA-synthesizing enzymes, glutamate decarboxylases GAD65 and GAD67.
Paraneoplastic disorders.
Review
New
Lancaster, In Continuum (minneap Minn), Apr 2015
A final group of disorders involves antibodies to intracellular synaptic proteins, such as glutamic acid decarboxylase 65 (GAD65), and it is unclear whether these diseases involve antibody or T-cell mechanisms.
How and why does tomato accumulate a large amount of GABA in the fruit?
Review
Ezura et al., Tsukuba, Japan. In Front Plant Sci, 2014
The GABA shunt bypasses two steps (the oxidation of α-ketoglutarate to succinate) of the tricarboxylic acid (TCA) cycle via reactions catalyzed by three enzymes: glutamate decarboxylase, GABA transaminase, and succinic semialdehyde dehydrogenase.
Variant GADL1 and response to lithium therapy in bipolar I disorder.
Impact
Taiwan Bipolar Consortium et al., Aş Şanamayn, Syria. In N Engl J Med, 2014
We sequenced the exons, exon-intron boundaries, and part of the promoter of the gene encoding glutamate decarboxylase-like protein 1 (GADL1) in 94 patients who had a response to lithium and in 94 patients who did not have a response in the genomewide association sample.
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
Impact
Harrison et al., Australia. In Nat Immunol, 2013
Humans with type 1 diabetes had a lower frequency and diminished function of CD52(hi)CD4(+) T cells responsive to the autoantigen GAD65.
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
Impact
Eisenbarth et al., München, Germany. In Jama, 2013
DESIGN, SETTING, AND PARTICIPANTS: Data were pooled from prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland (recruitment, 1994-2009), and Germany (recruitment, 1989-2006) examining children genetically at risk for type 1 diabetes for the development of insulin autoantibodies, glutamic acid decarboxylase 65 (GAD65) autoantibodies, insulinoma antigen 2 (IA2) autoantibodies, and diabetes.
Identification of novel DNA methylation markers in colorectal cancer using MIRA-based microarrays.
GeneRIF
Yang et al., Yinchuan, China. In Oncol Rep, 2012
PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue
Lateral regions of the rodent striatum reveal elevated glutamate decarboxylase 1 mRNA expression in medium-sized projection neurons.
GeneRIF
Sugimoto et al., Moriguchi, Japan. In Eur J Neurosci, 2012
The mouse lateral striatum concentrates medium-sized projection neurons with high-level expression of GAD1, but not of GAD2, mRNA.
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.
Impact
Baron et al., Linköping, Sweden. In N Engl J Med, 2012
BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes.
Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.
GeneRIF
Marsala et al., San Diego, United States. In Plos One, 2011
Treatment with orally bioavailable GABA-mimetic drugs if combined with spinal-segment-specific GAD65 gene overexpression can represent a novel and highly effective anti-spasticity treatment.
Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission.
GeneRIF
Wu et al., Boca Raton, United States. In Plos One, 2011
The levels of tGAD65 in the focal cerebral ischemic rat brain tissue increased corresponding to the elevation of local glutamate as indicated by microdialysis and were also proportional to the degree of cell death when exposed to high KCl.
Glutamic acid decarboxylase immunoreactivity in the mossy fiber terminals of the hippocampus of genetic absence epileptic rats.
GeneRIF
San et al., İstanbul, Turkey. In Turk Neurosurg, 2010
GAD65 is found in mossy fiber terminals of Wistar and GAERS rat hippocampus. This enzyme does not show an increase in these terminals in absence epilepsy.
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