Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
Malmö, Sweden. In Diabetes, Feb 2016
UNASSIGNED: The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear.
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.
Miami, United States. In Curr Diab Rep, Dec 2015
T1DR is typically characterized by (1) variable degree of insulitis and loss of insulin staining, on pancreas transplant biopsy (with most often absent), minimal to moderate and rarely severe pancreas, and/or kidney transplant rejection; (2) the conversion of T1D-associated autoantibodies (to the autoantigens GAD65, IA-2, and ZnT8), preceding hyperglycemia by a variable length of time; and (3) the presence of autoreactive T cells in the peripheral blood, pancreas transplant, and/or peripancreatic transplant lymph nodes.
How and why does tomato accumulate a large amount of GABA in the fruit?
Tsukuba, Japan. In Front Plant Sci, 2014
The GABA shunt bypasses two steps (the oxidation of α-ketoglutarate to succinate) of the tricarboxylic acid (TCA) cycle via reactions catalyzed by three enzymes: glutamate decarboxylase, GABA transaminase, and succinic semialdehyde dehydrogenase.
Variant GADL1 and response to lithium therapy in bipolar I disorder.
Aş Şanamayn, Syria. In N Engl J Med, 2014
We sequenced the exons, exon-intron boundaries, and part of the promoter of the gene encoding glutamate decarboxylase-like protein 1 (GADL1) in 94 patients who had a response to lithium and in 94 patients who did not have a response in the genomewide association sample.
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
München, Germany. In Jama, 2013
DESIGN, SETTING, AND PARTICIPANTS: Data were pooled from prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland (recruitment, 1994-2009), and Germany (recruitment, 1989-2006) examining children genetically at risk for type 1 diabetes for the development of insulin autoantibodies, glutamic acid decarboxylase 65 (GAD65) autoantibodies, insulinoma antigen 2 (IA2) autoantibodies, and diabetes.