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Solute carrier family 2,

GLUT8, GLUT12, glucose transporter 8
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Insulin, HAD, ACID, V1a, CAN
Papers on GLUT8
AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle.
Lacombe et al., Stillwater, United States. In Vet J, Sep 2015
While GLUT4 and GLUT1 protein expression remained unchanged, GLUT8 was increased (P <0.05) following AICAR treatment.
Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
Lostao et al., Pamplona, Spain. In Am J Physiol Cell Physiol, Jul 2015
GLUT12 is a member of the facilitative family of glucose transporters.
GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.
Marín-Juez et al., Utrecht, Netherlands. In J Endocrinol, 2015
In this light, to assist in the understanding of the role of insulin-regulated glucose transporters (GLUTs) and the development of cardiomyopathies, we have developed a model for glut12 deficiency in zebrafish.
Role of adiponectin in delayed embryonic development of the short-nosed fruit bat, Cynopterus sphinx.
Krishna et al., Benares, India. In Mol Reprod Dev, 2014
An in vitro study further confirmed the in vivo findings that adiponectin treatment increases PCNA levels together with increased uptake of glucose by increasing the abundance of glucose transporter 8 (GLUT8) in the utero-embryonic unit.
Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria.
Lacombe et al., Oklahoma City, United States. In Plos One, 2014
Although GLUT4 is the major isoform in the heart, GLUT8 has recently emerged as a novel cardiac isoform.
Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet.
Lacombe et al., Oklahoma City, United States. In Plos One, 2014
TLR4-mutant mice fed a HFD also had increased expression of GLUT8, a novel isoform, compared to mice fed a normal diet.
Cloning and functional analysis of goat SWEET1.
Yu et al., Nanjing, China. In Genet Mol Res, 2014
Goat SWEET1 overexpression can reduce glucose absorption in mammary gland epithelial cells with increasing expression of GLUT1, GLUT4, and GLUT12, which may be attributed to glucose efflux arising from the leading role played by goat SWEET1.
Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report.
Evans et al., Pamplona, Spain. In J Cancer, 2014
BACKGROUND: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.
Phylogenesis and Biological Characterization of a New Glucose Transporter in the Chicken (Gallus gallus), GLUT12.
Métayer-Coustard et al., France. In Plos One, 2014
A nucleotide sequence is predicted to encode a chicken GLUT12 ortholog and, interestingly, GLUT12 has been described to act as an insulin-sensitive GLUT in mammals.
Biology of glucose transport in the mammary gland.
Zhao, Burlington, United States. In J Mammary Gland Biol Neoplasia, 2014
Mammary glands mainly express GLUT1 and GLUT8, and GLUT1 is the predominant isoform with a Km of ~10 mM and transport activity for mannose and galactose in addition to glucose.
Glucose transport in brain - effect of inflammation.
Jurcovicova, In Endocr Regul, 2014
GLUT4 and GLUT8 are insulin-regulated glucose transporters in neuronal cell bodies in the cortex and cerebellum, but mainly in the hippocampus and amygdala, where they maintain hippocampus-dependent cognitive functions.
Response gene to complement 32 (RGC-32) in endothelial cells is induced by glucose and helpful to maintain glucose homeostasis.
Wu et al., Beijing, China. In Int J Clin Exp Med, 2013
DNA array analysis and qPCR results showed that glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1), solute carrier family 2 (facilitated glucose transporter), member 12 (SLC2A12, GLUT12) and glucagon-like peptide 2 receptor (GLP2R) may be among possible glucose metabolism related downstream genes of RGC-32.
Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization.
Moley et al., Saint Louis, United States. In Endocrinology, 2012
Data conclude that GLUT8 regulates enterocyte fructose transport by regulating GLUT12, and that disrupted GLUT8 function has deleterious long-term metabolic sequelae.
Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.
Shanmugam et al., Chicago, United States. In Blood, 2012
Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer.
Glucose transporters GLUT4 and GLUT8 are upregulated after facial nerve axotomy in adult mice.
Terrado et al., Moncada, Spain. In J Anat, 2011
increased in regenerating motoneurons on Day 8 post-lesion
Improved insulin sensitivity by GLUT12 overexpression in mice.
Moley et al., Saint Louis, United States. In Diabetes, 2011
Increased expression of GLUT12 results in improved whole-body insulin sensitivity mediated by an increased glucose clearance rate in insulin-responsive tissues under insulin-stimulated, but not basal, conditions.
The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12.
Moley et al., Saint Louis, United States. In Mol Membr Biol, 2011
XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12
GLUT8, the enigmatic intracellular hexose transporter.
Schürmann et al., Potsdam, Germany. In Am J Physiol Endocrinol Metab, 2009
GLUT8 is a class III sugar transporter predominantly expressed in testis and brain.
Expression and regulation of glucose transporters in the bovine mammary gland.
Keating et al., Burlington, United States. In J Dairy Sci, 2007
However, the bovine lactating mammary gland also expresses GLUT3, GLUT4, GLUT5, GLUT8, GLUT12, and sodium-dependent SGLT1 and SGLT2 at different levels.
The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.
Schürmann et al., Potsdam, Germany. In Jpen J Parenter Enteral Nutr, 2004
Furthermore, some transporters (eg, GLUT4 and GLUT8) are regulated by their subcellular distribution.
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