Pharmacogenetic study of long-term response to interferon-β treatment in multiple sclerosis.
Milano, Italy. In Pharmacogenomics J, Jan 2016
Finally, we found an enrichment of pathways related to inflammatory processes and presynaptic membrane, the latter with involvement of genes related to glutamatergic system (GRM3 and GRIK2), confirming its potential role in the response to IFNβ.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.85.
Gene polymorphisms and oral cancer risk in tobacco habitués.
Mumbai, India. In Tumour Biol, Dec 2015
The SNPs rs2124437 (RASGRP3), rs1335022 (GRIK2), rs4512367 (PREX2), rs4748011 (CCDC3), and rs1435218 (LNX1) were analyzed in 500 histopathologically confirmed oral cancers and 500 healthy controls with a minimum of 10 years of tobacco usage.
Suita, Japan. In Handb Exp Pharmacol, 2013
We further demonstrated that Trpm1 is a component of the transduction cation channel negatively regulated by the metabotropic glutamate receptor 6 (mGulR6) cascade in ON-bipolar cells through a reconstitution experiment using CHO cells expressing Trpm1, mGluR6, and Goα.