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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, ionotrophic, AMPA 4

GluR4, mGluR4
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GluR2, GluR1, ACID, GluR3, mGluR
Papers on GluR4
Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies.
New
Śmiałowska et al., Kraków, Poland. In Neuropharmacology, Mar 2016
In the in vitro study, we also demonstrated the neuroprotective potential of mGluR4 positive allosteric modulators (PAMs), PHCCC (30 μM) and VU0155041 (10 and 30 μM) and synergism in neuroprotective action of low concentrations of ACPT-I and mGluR4 PAMs suggesting an important role of mGluR4 activation in prevention of ischemic neuronal cell death.
Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4).
New
Zhang et al., Chiba, Japan. In Bioorg Med Chem Lett, Feb 2016
ADX88178 (1) has been recently developed as a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4).
7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
New
Sabio et al., Hoboken, United States. In Bioorg Med Chem Lett, Feb 2016
Similarly, using homology models that we built for mGluR2 and mGluR4, we have identified the factors leading to the selectivity between group I and groups II and III for ligands occupying the deepest portion of the mGluR5 binding cavity.
Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells.
New
Delay et al., Burlington, United States. In Neuroscience, Jan 2016
These include the heterodimer taste receptor type 1 member 1 (T1r1)+taste receptor type 1 member 3 (T1r3), taste and brain variants of mGluR4 and mGluR1, and calcium sensors.
BMP4: a Possible Key Factor in Differentiation of Auditory Neuron-Like Cells from Bone-Derived Mesenchymal Stromal Cells.
Xie et al., In Clin Lab, 2014
In the presence of BMP4, the inner ear genes NF-M, Neurog1, GluR4, NeuroD, Calretinin, NeuN, Tau, and GATA3 were up-regulated in MSCs.
Umami the Fifth Basic Taste: History of Studies on Receptor Mechanisms and Role as a Food Flavor.
Review
Kurihara, Aomori, Japan. In Biomed Res Int, 2014
Three umami receptors (T1R1 + T1R3, mGluR4, and mGluR1) were identified.
Group III metabotropic glutamate receptors and drug addiction.
Review
Wang et al., In Front Med, 2013
Emerging evidence also identifies Gαi/o-coupled group III mGluRs (mGluR4/7/8 subtypes enriched in the limbic system) as direct substrates of drugs of abuse and active regulators of drug action.
Orthosteric versus allosteric GPCR activation: the great challenge of group-III mGluRs.
Review
Acher et al., Regensburg, Germany. In Biochem Pharmacol, 2012
Group-III metabotropic glutamate receptors (mGluRs) comprise four structurally related brain and retinal G protein-coupled receptors (GPCRs), mGluR4, mGluR6, mGluR7 and mGluR8, which receive much attention as promising targets for nervous system drugs.
Bergmann glial AMPA receptors are required for fine motor coordination.
Impact
GeneRIF
Kirchhoff et al., Homburg, Germany. In Science, 2012
study found the majority of cerebellar GluA1/A4-type AMPARs are expressed in Bergmann glial (BG) cells; BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life
Native presynaptic metabotropic glutamate receptor 4 (mGluR4) interacts with exocytosis proteins in rat cerebellum.
GeneRIF
Le Maréchal et al., Orsay, France. In J Biol Chem, 2012
native mGluR4 interacts with several exocytosis proteins such as Munc18-1, synapsins, and syntaxin.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
GeneRIF
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that gira4 gene expression in mouse dorsal raphe nucleus
Measures of anxiety, sensorimotor function, and memory in male and female mGluR4⁻/⁻ mice.
GeneRIF
Raber et al., Portland, United States. In Behav Brain Res, 2012
These data indicate that effects of mGluR4 on sensorimotor function and measures of anxiety, but not cued fear conditioning, are critically modulated by sex and age.
Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders.
Review
Campo et al., Genève, Switzerland. In Expert Opin Drug Discov, 2012
INTRODUCTION: The metabotropic glutamate receptor type 4 (mGluR4) plays a pivotal role in a plethora of therapeutic areas, as recently demonstrated in preclinical validation studies with several chemical classes of compounds in rodent models of central nervous system (CNS) and peripheral disorders.
Selective reduction of AMPA currents onto hippocampal interneurons impairs network oscillatory activity.
GeneRIF
Monyer et al., Heidelberg, Germany. In Plos One, 2011
The GluA4 subunit of the AMPA receptor in the hippocampus (GluA4(HC-/-) mice) was ablated, thereby selectively reducing AMPA receptor-mediated currents onto a subgroup of hippocampal interneurons expressing GluA4.
mGluRs modulate strength and timing of excitatory transmission in hippocampal area CA3.
Review
Meriney et al., Chicago, United States. In Mol Neurobiol, 2011
Within area CA3 of the hippocampus, group I mGluRs (mGluR1 and mGluR5) are expressed postsynaptically, whereas group II (mGluR2 and mGluR3) and III mGluRs (mGluR4, mGluR7, and mGluR8) are expressed presynaptically.
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.
Impact
GeneRIF
Di Marco et al., Perugia, Italy. In Nat Med, 2010
Grm4 modulates adaptive immunity and restrains neuroinflammation.
Detection of sweet and umami taste in the absence of taste receptor T1r3.
Impact
Margolskee et al., New York City, United States. In Science, 2003
Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors.
Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells.
Impact
Ozawa et al., Maebashi, Japan. In Nat Med, 2002
Here, we showed that glioblastoma cells express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptors assembled from the GluR1 and/or GluR4 subunits, and that their conversion to Ca(2+)-impermeable receptors by adenovirus-mediated transfer of the GluR2 cDNA inhibited cell locomotion and induced apoptosis.
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb.
Impact
Nakanishi et al., Kyoto, Japan. In Nature, 1994
The metabotropic glutamate receptors (mGluRs) consists of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown.
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA.
Impact
Heinemann et al., Los Angeles, United States. In Nature, 1991
Sequence homology between complementary DNA clones encoding non-NMDA glutamate receptor subunits reveals at least two subunit classes: the GluR1 to GluR4 class and the GluR5 class.
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