New targets for rapid antidepressant action.
Bethesda, United States. In Prog Neurobiol, Jan 2016
We also briefly discuss several other theoretical glutamate receptor targets with preclinical antidepressant-like efficacy that have yet to be studied clinically; these include α-amino-3-hydroxyl-5-methyl-4-isoxazoleproprionic acid (AMPA) agonists and mGluR2/3 negative allosteric modulators.
Building models for postmortem abnormalities in hippocampus of schizophrenics.
Belmont, United States. In Schizophr Res, Sep 2015
Abnormal expression changes in the expression of kainate receptor (KAR) subunits 5, 6 and 7, as well as an inwardly-rectifying hyperpolarization-activated cationic channel (Ih3; HCN3) may play important roles in regulating GABA cell activity at the SO CA3/2 locus.
Structural mechanism of glutamate receptor activation and desensitization.
Bethesda, United States. In Nature, 2014
To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional states and analysed the resulting structures using cryo-electron microscopy.