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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, ionotropic, AMPA 2

GluR2, kainate receptor, mGluR2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GluR1, CAN, V1a, HAD
Papers using GluR2 antibodies
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... GluR2Abcam ...
Papers on GluR2
Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway.
Niu et al., Taiyuan, China. In Neurotox Res, Feb 2016
Our results reveal that Al treatment produces a dose-dependent suppression of LTP and decreases in the AMPAR subunits GluR1 and GluR2, in both membrane and total cell extracts.
Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans.
Kellner et al., Hamburg, Germany. In Int Clin Psychopharmacol, Feb 2016
UNASSIGNED: Group II metabotropic glutamate receptors (mGluR2/3) are suggested to modulate anxiety, arousal, and stress including autonomic control.
Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.
Luhmann et al., Mainz, Germany. In Neurobiol Dis, Feb 2016
In addition, the AMPA/kainate receptor antagonist CNQX suppressed the remaining epileptiform activity.
New targets for rapid antidepressant action.
Zarate et al., Bethesda, United States. In Prog Neurobiol, Jan 2016
We also briefly discuss several other theoretical glutamate receptor targets with preclinical antidepressant-like efficacy that have yet to be studied clinically; these include α-amino-3-hydroxyl-5-methyl-4-isoxazoleproprionic acid (AMPA) agonists and mGluR2/3 negative allosteric modulators.
Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands.
Celada et al., Barcelona, Spain. In Eur Neuropsychopharmacol, Dec 2015
However, the enhancement of GABAA-R-mediated neurotransmission (using muscimol, diazepam or valproate) and the reduction of excitatory neurotransmission (using the mGluR2/3 agonist LY379268 and the preferential kainite/AMPA antagonist CNQX - but not the preferential AMPA/kainate antagonist NBQX) partially or totally countered PCP effects.
Toward a better understanding of the central consequences of intestinal inflammation.
Pittman et al., Calgary, Canada. In Ann N Y Acad Sci, Sep 2015
There are significant changes in excitatory, AMPA receptor-mediated transmission, in part due to increased numbers of AMPA receptors lacking the GluR2 subunit.
Building models for postmortem abnormalities in hippocampus of schizophrenics.
Benes, Belmont, United States. In Schizophr Res, Sep 2015
Abnormal expression changes in the expression of kainate receptor (KAR) subunits 5, 6 and 7, as well as an inwardly-rectifying hyperpolarization-activated cationic channel (Ih3; HCN3) may play important roles in regulating GABA cell activity at the SO CA3/2 locus.
Conformational dynamics of a class C G-protein-coupled receptor.
Isacoff et al., Berkeley, United States. In Nature, Sep 2015
Unlike mGluR2, mGluR3 displays basal dynamics, which are Ca(2+)-dependent and lead to basal protein activation.
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.
Traynelis et al., United States. In Mol Pharmacol, Jul 2015
Similarly, the most common phenotype for kainate receptor variants is intellectual disability.
Emerging structural insights into the function of ionotropic glutamate receptors.
Furukawa et al., United States. In Trends Biochem Sci, Jun 2015
These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers.
Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat.
Leem et al., Seoul, South Korea. In Mediators Inflamm, 2014
When intraplantar ( injection was administered into the L4 dermatome before ES, NMDAR and group-I metabotropic Glu receptor (mGluR) antagonists and group-II mGluR agonist but not AMPA/kainate receptor antagonist prevented ES-induced hypersensitivity.
Structural mechanism of glutamate receptor activation and desensitization.
Subramaniam et al., Bethesda, United States. In Nature, 2014
To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional states and analysed the resulting structures using cryo-electron microscopy.
LTP requires a reserve pool of glutamate receptors independent of subunit type.
Nicoll et al., San Francisco, United States. In Nature, 2013
In fact, replacement with the GluA2 subunit showed normal LTP, as did an artificially expressed kainate receptor not normally found at these synapses.
Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function.
Swanson et al., Chicago, United States. In Nat Rev Neurosci, 2012
Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.
Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival.
Kim et al., Seoul, South Korea. In Br J Cancer, 2012
We demonstrated that the expression of GRIA2 among the differentially expressed genes provides better prognosis of patients with advanced serous papillary ovarian adenocarcinoma.
Calcium-permeable AMPA receptors provide a common mechanism for LTP in glutamatergic synapses of distinct hippocampal interneuron types.
Lamsa et al., Oxford, United Kingdom. In J Neurosci, 2012
The strong inward rectification and calcium permeability of AMPA receptors is explained by a low level of GluA2 subunit mRNA expression in hippocampal interneuron synapses.
Regulation of N-methyl-D-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7.
Yan et al., Buffalo, United States. In J Biol Chem, 2012
mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function
Rapid glutamate receptor 2 trafficking during retinal degeneration.
Marc et al., Salt Lake City, United States. In Mol Neurodegener, 2011
Light-induced retinal degeneration rapidly triggers GluR2 plasticity, which is a potential mechanism behind functionally phenotypic revisions of retinal neurons and neuritogenesis during retinal degenerations.
Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats.
See et al., Charleston, United States. In Plos One, 2011
analysis of extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
Logothetis et al., New York City, United States. In Cell, 2011
We now show that a heteromeric complex between the 2AR and the G(i)-linked GPCR, metabotropic glutamate 2 receptor (mGluR2), integrates ligand input, modulating signaling output and behavioral changes.
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