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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, ionotropic, AMPA 1

GluR1, Glutamate receptor
mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GluR2, ACID, CAN, NMDA receptor, V1a
Papers on GluR1
Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway.
New
Niu et al., Taiyuan, China. In Neurotox Res, Feb 2016
Our results reveal that Al treatment produces a dose-dependent suppression of LTP and decreases in the AMPAR subunits GluR1 and GluR2, in both membrane and total cell extracts.
The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats.
New
Gorji et al., Tehrān, Iran. In Mol Neurobiol, Feb 2016
UNASSIGNED: Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy.
Challenges in developing drugs for primary headache.
Review
New
Ashina et al., Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
Glutamate receptor antagonism whilst efficacious has central side effects and some approaches such as nitric oxide synthase inhibition, substance P antagonism and cortical spreading depression blockade, despite having promising effects in basic pain models, have not delivered efficacy in the clinic.
Sex-dependent and independent effects of long-term voluntary wheel running on bdnf mRNA and protein expression.
New
Roth et al., College Park, United States. In Physiol Behav, Feb 2016
Total RNA was isolated from the hippocampus and expression of total Bdnf, Bdnf transcript IV, tPA, Pgc-1a, GluR1, NR2A, and NR2B were assessed with quantitative RT-PCR and total and mature Bdnf protein were assessed with ELISA.
Fear Potentiated Startle Increases Phospholipase D (PLD) Expression/Activity and PLD-Linked Metabotropic Glutamate Receptor Mediated Post-Tetanic Potentiation in Rat Amygdala.
New
Shinnick-Gallagher et al., Galveston, United States. In Neurobiol Learn Mem, Jan 2016
UNASSIGNED: Long-term memory (LTM) of fear stores activity dependent modifications that include changes in amygdala signaling.
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1.
New
Kanekiyo et al., Jacksonville, United States. In Exp Neurol, Jan 2016
While levels of PSD95, glutamate receptor 1 (GluR1), and N-methyl-d-aspartate receptor NR1 subunit (NR1), which are key postsynaptic proteins that regulate synaptic plasticity, were decreased with aging, they were restored by bexarotene treatment in the brains of control but not nLrp1(-/-) mice.
Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains.
Review
New
Greger et al., Cambridge, United Kingdom. In Biophys J, Oct 2015
Ionotropic glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic transmission and plasticity.
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.
Review
New
Traynelis et al., United States. In Mol Pharmacol, Jul 2015
A new and unexpected outcome from sequencing efforts has been the surprising number of mutations found in glutamate receptor subunits, with the GRIN2A gene encoding the GluN2A N-methyl-d-aspartate receptor subunit being most often affected.
Glutamate receptor pores.
Review
Huettner, Saint Louis, United States. In J Physiol, 2015
This article focuses on the pore region, reviewing how structural differences among glutamate receptor subtypes determine their distinct functional properties.
Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence.
Review
Markou et al., San Diego, United States. In Cns Neurol Disord Drug Targets, 2014
One presynaptic inhibitory glutamate receptor that critically regulates glutamate transmission is the metabotropic glutamate 7 receptor (mGluR7).
Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.
Review
Impact
Charney et al., Bethesda, United States. In Annu Rev Pharmacol Toxicol, 2013
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant effects in treatment-resistant major depressive disorder and bipolar depression.
βCaMKII in lateral habenula mediates core symptoms of depression.
Impact
Hu et al., Shanghai, China. In Science, 2013
Down-regulation of βCaMKII levels, blocking its activity or its target molecule the glutamate receptor GluR1 reversed the depressive symptoms.
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.
Impact
Worley et al., Baltimore, United States. In Cell, 2013
In response to D1-dopamine-receptor signaling that is induced by drug administration, the glutamate-receptor protein metabotropic glutamate receptor 5 (mGluR5) is phosphorylated by microtubule-associated protein kinase (MAPK), which we show potentiates Pin1-mediated prolyl-isomerization of mGluR5 in instances where the product of an activity-dependent gene, Homer1a, is present to enable Pin1-mGluR5 interaction.
Bergmann glial AMPA receptors are required for fine motor coordination.
Impact
GeneRIF
Kirchhoff et al., Homburg, Germany. In Science, 2012
study found the majority of cerebellar GluA1/A4-type AMPARs are expressed in Bergmann glial (BG) cells; BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life
The effects of GluA1 deletion on the hippocampal population code for position.
GeneRIF
Mehta et al., Heidelberg, Germany. In J Neurosci, 2012
The results of this study suggested that the impaired experience-dependent plasticity and trial-by-trial stability of the GluA1-/- neurons, rate maps in particular could lead to the impaired working memory performance
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Impact
GeneRIF
Barres et al., Stanford, United States. In Nature, 2012
Gpc4-deficient mice have defective synapse formation, with decreased amplitude of excitatory synaptic currents in the developing hippocampus and reduced recruitment of AMPARs to synapses
Mutations causing syndromic autism define an axis of synaptic pathophysiology.
Impact
Bear et al., Cambridge, United States. In Nature, 2012
Synaptic, biochemical and cognitive defects in these mutants are corrected by treatments that modulate metabotropic glutamate receptor 5 in opposite directions, and deficits in the mutants disappear when the mice are bred to carry both mutations.
Identification of a novel signaling pathway and its relevance for GluA1 recycling.
GeneRIF
Strutz-Seebohm et al., Bochum, Germany. In Plos One, 2011
This RAB-dependent GluA1 trafficking requires phosphorylation and activation of phosphoinositol-3-phosphate-5-kinase (PIKfyve) and the generation of PI(3,5)P(2).
GluA1 phosphorylation alters evoked firing pattern in vivo.
GeneRIF
Szegedi et al., Szeged, Hungary. In Neural Plast, 2011
Phosphorylation of AMPA receptor subunit GluA1 alters neuronal plasticity and temporal coding.
Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine.
Impact
Feijó et al., Portugal. In Science, 2011
Here, we show by pharmacology and loss-of-function mutants that in tobacco and Arabidopsis, glutamate receptor-like channels (GLRs) facilitate Ca(2+) influx across the plasma membrane, modulate apical [Ca(2+)](cyt) gradient, and consequently affect pollen tube growth and morphogenesis.
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