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Glucose-6-phosphate isomerase

Glucose-6-Phosphate Isomerase
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, fibrillin-1, Hexokinase
Papers on Glucose-6-Phosphate Isomerase
In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.
New
Kamradt et al., Jena, Germany. In Eur J Immunol, Jan 2016
Using the glucose-6-phosphate isomerase (G6PI)-induced arthritis model in mice, we aimed to determine the therapeutic efficacy of increasing Treg-cell number and function during chronic destructive arthritis.
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
New
Sood et al., Houston, United States. In Cell Rep, Jan 2016
We identified NRCP as an intermediate binding partner between STAT1 and RNA polymerase II, leading to increased expression of downstream target genes such as glucose-6-phosphate isomerase.
Influence of age on rat bone-marrow mesenchymal stem cells potential.
Arufe et al., A Coruña, Spain. In Sci Rep, 2014
Enzimoimmunoassay analysis of several enzymes as L-lactate dehydrogenase and glucose-6-phosphate isomerase were also done to validate iTRAQ data.
The rumen microbial metagenome associated with high methane production in cattle.
Roehe et al., Edinburgh, United Kingdom. In Bmc Genomics, 2014
Genes less abundant in high emitters included acetate kinase, electron transport complex proteins RnfC and RnfD and glucose-6-phosphate isomerase.
Kinetic and thermodynamic characterization of the interactions between the components of human plasma kinin-forming system and isolated and purified cell wall proteins of Candida albicans.
Rapala-Kozik et al., Kraków, Poland. In Acta Biochim Pol, 2014
Five of these fungal proteins, including agglutinin-like sequence protein 3 (Als3), triosephosphate isomerase 1 (Tpi1), enolase 1 (Eno1), phosphoglycerate mutase 1 (Gpm1) and glucose-6-phosphate isomerase 1 (Gpi1), were purified and characterized in terms of affinities to the human contact factors, using the surface plasmon resonance measurements.
HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties.
GeneRIF
Seliger et al., Halle, Germany. In J Biol Chem, 2012
Bgn inhibits the major properties of HER-2/neu-transformed cells, which is inversely modulated by the PKC signaling cascade.
Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells.
GeneRIF
Hida et al., Sapporo, Japan. In Br J Cancer, 2012
These findings suggested that biglycan is a novel tumor endothelial cell marker and a target for anti-angiogenic therapy
Biglycan is an extracellular MuSK binding protein important for synapse stability.
GeneRIF
Fallon et al., Providence, United States. In J Neurosci, 2012
Extracellular matrix protein biglycan plays a novel role in regulating synapse stability.
Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition.
GeneRIF
Lechner et al., Providence, United States. In Plos One, 2011
Biglycan/decorin mixed double knockout mouse is a model of dystocia and delayed labor onset.
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
GeneRIF
Granville et al., Vancouver, Canada. In Plos One, 2011
Data show that granzyme B (GrB) liberated TGF-beta1 from substrates decorin, biglycan and betaglycan.
[Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis].
Review
Sumida et al., Tsukuba, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Immunization of DBA/1 mice with glucose-6-phosphate isomerase (GPI) induces severe acute arthritis.
[Animal models for bone and joint disease. K/BxN mice - serum transferred arthritis -].
Review
Matsumoto, Tsukuba, Japan. In Clin Calcium, 2011
K/BxN mice spontaneously develop severe symmetrical polyarthritis, and serum from these mice induces a similar arthritis in a wide range of mouse strains, due to autoantibodies recognizing glucose-6-phosphate isomerase (GPI) .
[Diagnostic value of glucose-6-phosphate isomerase in rheumatoid arthritis patients: systematic review].
Review
Bai et al., Chengdu, China. In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2010
In order to evaluate the diagnostic accuracy of glucose-6-phosphate isomerase in patients with rheumatoid arthritis, retrieval was performed using the data bases of Medline, Embase, Cochrane library, Cmcc and Cbmdisc (1990 to 2007).
Chondroitin sulfate and abnormal contact system in rheumatoid arthritis.
Review
Zhang et al., Saint Louis, United States. In Prog Mol Biol Transl Sci, 2009
In the K/BxN mouse model of RA, autoantibodies specific for glucose-6-phosphate isomerase (GPI) from these mice can transfer joint-specific inflammation to normal mice.
[The pathogenic role and production system of autoantibody in rheumatoid arthritis].
Review
Matsumoto, Tsukuba, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2005
Several antibodies (Abs) were identified from sera from RA patients such as rheumatoid factor, anti-CCP Abs, anti-glucose-6-phosphate isomerase Abs, anti-calpastatin Abs, anti-soluble gp130 Abs, anti-collagen type II Abs, etc.
Dynamic visualization of a joint-specific autoimmune response through positron emission tomography.
Impact
Allen et al., Saint Louis, United States. In Nat Immunol, 2002
In the K/BxN mouse model of rheumatoid arthritis, the transfer of autoantibodies specific for glucose-6-phosphate isomerase (GPI) into naïve mice rapidly induces joint-specific inflammation similar to that seen in human rheumatoid arthritis.
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease.
Impact
Benoist et al., Boston, United States. In Nat Immunol, 2002
Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins (Igs) that recognize the ubiquitous cytoplasmic enzyme glucose-6-phosphate isomerase (GPI).
Arthritis critically dependent on innate immune system players.
Impact
Mathis et al., Boston, United States. In Immunity, 2002
Disease in these animals is focused specifically on the joints but stems from autoreactivity to a ubiquitously expressed antigen, glucose-6-phosphate isomerase (GPI).
Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease.
Impact
Ditzel et al., Los Angeles, United States. In Nat Immunol, 2001
In K/BxN T cell receptor-transgenic mice, spontaneous inflammatory arthritis exhibiting many of the features of human rheumatoid arthritis (RA) is initiated by T cells, but is almost entirely sustained by antibodies to the self-antigen glucose-6-phosphate isomerase (GPI).
Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
Impact
Mathis et al., Strasbourg, France. In Science, 1999
In this study, the target of both the initiating T cells and pathogenic immunoglobulins was identified as glucose-6-phosphate isomerase, a glycolytic enzyme.
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