Preexisting conditions in pediatric ALL patients: Spectrum, frequency and clinical impact.
Hannover, Germany. In Eur J Med Genet, Jan 2016
The following conditions were reported in more than one patient: Gilbert's disease (n=13), neurofibromatosis type I (n=8), ataxia telangiectasia (n=8), thalassemia (n=7), Nijmegen Breakage syndrome (n=6), cystic fibrosis (n=4), glucose-6-phosphate dehydrogenase deficiency (n=4), Noonan syndrome (n=2), Klinefelter syndrome (n=2), alpha-1-antitrypsin deficiency (n=2), primary ciliary dyskinesia (n=2).
Global burden of genetic disease and the role of genetic screening.
New Delhi, India. In Semin Fetal Neonatal Med, Oct 2015
In developing, as compared to western countries, hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency have a higher incidence due to severe falciparum malaria in the distant past, and autosomal recessive disorders have a higher frequency due to greater proportion of consanguineous marriages.
Therapeutic potential of manipulating suicidal erythrocyte death.
Tübingen, Germany. In Expert Opin Ther Targets, 2014
AREAS COVERED: Stimulation of eryptosis contributes to anemia of several clinical conditions such as metabolic syndrome, diabetes, malignancy, hepatic failure, heart failure, uremia, hemolytic uremic syndrome, sepsis, fever, dehydration, mycoplasma infection, malaria, iron deficiency, sickle cell anemia, thalassemia, glucose-6-phosphate dehydrogenase deficiency and Wilson's disease.