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Nuclear receptor subfamily 3, group C, member 1

glucocorticoid receptor
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, iMpact, GCS
Papers using glucocorticoid receptor antibodies
SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons.
Borlongan Cesario V., In PLoS ONE, 2004
... The glucocorticoid receptor (GR) agonist dexamethasone (DEX), obtained from Merck (Darmstadt, Germany) in aqueous ...
Papers on glucocorticoid receptor
Corticosteroids: Mechanisms of Action in Health and Disease.
Cidlowski et al., United States. In Rheum Dis Clin North Am, Feb 2016
The actions of glucocorticoids are predominantly mediated through the classic glucocorticoid receptor (GR).
21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action.
Burton et al., Buenos Aires, Argentina. In Mini Rev Med Chem, Feb 2016
UNASSIGNED: Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR), a ligand regulated transcription factor.
Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors.
Covaci et al., Sapporo, Japan. In Toxicol Lett, Feb 2016
In addition, these hydroxylated TPHP-metabolites also showed ERβ antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP.
Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.
Zhang et al., Suzhou, China. In J Mol Cell Cardiol, Feb 2016
The present study tested the hypothesis that gestational hypoxia leads to promoter hypermethylation and epigenetic repression of the glucocorticoid receptor (GR) gene in the developing heart, resulting in increased heart susceptibility to ischemia and reperfusion injury in offspring.
Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.
Athey et al., Ann Arbor, United States. In Neurogastroenterol Motil, Jan 2016
Cortisol binds with the GR in the cytosol, translocates to the nucleus, and activates the NR3C1 (nuclear receptor subfamily 3, group C, member 1 [GR]) gene.
Design and synthesis of novel androgen receptor antagonists via molecular modeling.
Cho et al., Kwangju, South Korea. In Bioorg Med Chem, Jan 2016
and also acted as a competitive AR antagonist with selectivity over the estrogen receptor (ER) and the glucocorticoid receptor (GR).
The Glucocorticoid Receptor: Cause or Cure for Obesity?
Hinds et al., Toledo, Philippines. In Am J Physiol Endocrinol Metab, Jan 2016
Conventional wisdom posits that these disparate outcomes are mediated by the classical glucocorticoid receptor GRα.
Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.
Franken et al., Genève, Switzerland. In Cold Spring Harb Symp Quant Biol, Jan 2016
Signaling through the glucocorticoid receptor and the serum response factor also participate in the phase entrainment of peripheral clocks, and these two pathways are controlled by the SCN independently of feeding-fasting rhythms.
The Treatment of Cushing's Disease.
Colao et al., Napoli, Italy. In Endocr Rev, Aug 2015
The adrenal-directed drug ketoconazole is the most commonly used drug, mainly because of its rapid action, whereas the glucocorticoid receptor antagonist, mifepristone, is highly effective in controlling clinical comorbidities, mainly glucose intolerance, thus being a useful treatment for CD when it is associated with diabetes mellitus.
PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.
Lodish et al., Cambridge, United States. In Nature, Jul 2015
Here we show that activation of the peroxisome proliferator-activated receptor α (PPAR-α) by the PPAR-α agonists GW7647 and fenofibrate synergizes with the glucocorticoid receptor (GR) to promote BFU-E self-renewal.
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Tesar et al., Cleveland, United States. In Nature, Jul 2015
Mechanistic studies show that miconazole and clobetasol function in oligodendrocyte progenitor cells through mitogen-activated protein kinase and glucocorticoid receptor signalling, respectively.
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Evans et al., Memphis, United States. In Nat Genet, Jun 2015
Overexpression of CASP1 resulted in cleavage of the glucocorticoid receptor, diminished the glucocorticoid-induced transcriptional response and increased glucocorticoid resistance.
Divergent transcriptional activation by glucocorticoids in mouse and human macrophages.
Hume et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
To assess the mechanism behind the regulation of transcription we also determined the DNA-binding pattern of the nuclear glucocorticoid receptor (GR) using chromatin immunoprecipitation followed by sequencing (ChIP-seq).
Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor.
Miyamoto et al., Baltimore, United States. In Dis Markers, 2014
These receptors include androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, vitamin D receptor, retinoid receptors, peroxisome proliferator-activated receptors, and others including orphan receptors.
Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder.
Praphanphoj et al., Bangkok, Thailand. In Genet Mol Res, 2014
This HPA negative feedback mechanism acts via the activation of glucocorticoid receptor, which is encoded by the NR3C1 gene.
Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity.
Maluf et al., Aurora, United States. In J Mol Biol, 2012
despite the complexity of glucocorticoid receptor function, DNA binding energetics are the primary determinant of sequence-specific transcriptional activity.
Glucocorticoid receptor activation inhibits p53-induced apoptosis of MCF10Amyc cells via induction of protein kinase Cε.
Maki et al., Chicago, United States. In J Biol Chem, 2012
activated GR can inhibit p53-dependent apoptosis through induction of the anti-apoptotic factor PKCepsilon.
Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.
't Hart et al., Amsterdam, Netherlands. In Diabet Med, 2012
Results show that N363S and ER22/23EK polymorphisms of the NR3C1 gene are negatively associated with parameters of beta-cell function in women, but not in men
NR3C1 gene polymorphism for genetic susceptibility to infantile spasms in a Chinese population.
Jia et al., Beijing, China. In Life Sci, 2012
importance of the NR3C1 gene polymorphism for genetic susceptibility to infantile spasms in a Chinese population
Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma, absence of stigmata of Cushing's syndrome and unusual histologic features.
Stratakis et al., Bethesda, United States. In J Pediatr Endocrinol Metab, 2011
Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma.
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