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GLI family zinc finger 3

Gli3, PHS, ACLS, PAPA
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Gli, Shh
Papers using Gli3 antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Supplier
Grzeschik Karl-Heinz et al., In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on Gli3
Acridine based (S,N,S) pincer ligand: designing silver(i) complexes for the efficient activation of A(3) (aldehyde, alkyne and amine) coupling.
New
Singh et al., Delhi, India. In Dalton Trans, 10 Jan 2015
UNLABELLED: Complexes [AgL(NO3)CH3CN]() and [AgLNO3] () were formed on reacting AgNO3 with L in acetonitrile for 12 h (at room temperature) and 24 h (at 90 °C), respectively, where L is a (S,N,S) pincer ligand, 4,5-bis(phenylthiomethyl)acridine, synthesized by the reaction of in situ generated PhS(-) with 4,5-bis(bromomethyl)acridine under N2 atmosphere.
Identification of candidate genes, regions and markers for pre-harvest sprouting resistance in wheat (Triticum aestivum L.).
New
Pozniak et al., In Bmc Plant Biol, 29 Dec 2014
UNLABELLED: BackgroundPre-harvest sprouting (PHS) of wheat grain leads to a reduction in grain yield and quality.
Pallister-Hall syndrome has gone the way of modern medical genetics.
New
Hall, In Am J Med Genet C Semin Med Genet, 25 Dec 2014
Genotype/phenotype correlations have led to fine mapping of GLI3 and the recognition that PHS is caused by dominant negative mutations in the middle third of the gene.
Kelussia odoratissima Mozzaf - A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude.
New
Khajali et al., Sārī, Iran. In J Ethnopharmacol, 15 Dec 2014
Lowering blood pressure effects of Kelussia odoratissima Mozzaf (wild celery) was evaluated in preventing pulmonary hypertension syndrome (PHS) in broiler chickens reared at high altitude (2100m).
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
New
Impact
Leung et al., San Diego, United States. In Nat Genet, Jun 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mutant PTEN in Cancer: Worse Than Nothing.
New
Impact
den Hertog et al., Utrecht, Netherlands. In Cell, May 2014
Papa et al.
Classification of Five Uremic Solutes according to Their Effects on Renal Tubular Cells.
New
Itoh et al., Tokyo, Japan. In Int J Nephrol, Dec 2013
We conducted a comparative study to examine the similarities and differences between IS, p-cresyl sulfate (PCS), phenyl sulfate (PhS), hippuric acid (HA), and indoleacetic acid (IAA).
A translational approach to congenital non-obstructive hydronephrosis.
Review
New
Rosenblum et al., Toronto, Canada. In Pediatr Nephrol, Sep 2013
Recent data demonstrate that hedgehog signaling plays a critical role in regulating the structure and function of the collecting system in a manner dependent on the formation of GLI3 repressor.
[Sonic Hedgehog signaling pathway and regulation of inner ear development].
Review
New
Cao et al., Nanjing, China. In Yi Chuan, Sep 2013
In humans, diseases accompanied by hearing disorders caused by abnormal Shh signaling include Greig cephalopolysyndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS), Waardenburg syndrome (WS) and medulloblastoma, etc.
Monogenic autoinflammatory diseases: concept and clinical manifestations.
Review
New
Goldbach-Mansky et al., Bethesda, United States. In Clin Immunol, Jun 2013
The autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary "periodic fever syndromes", familial Mediterranean Fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency.
Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues.
Review
Cantarini et al., Padova, Italy. In Int J Rheumatol, 2012
To date, there are twelve known MAISs: familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, familial cold urticaria syndrome, Muckle-Wells syndrome, CINCA syndrome, mevalonate kinase deficiency, NLRP12-associated autoinflammatory disorder, Blau syndrome, early-onset sarcoidosis, PAPA syndrome, Majeed syndrome, and deficiency of the interleukin-1 receptor antagonist.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Monogenic causes of inflammatory disease in rheumatology.
Review
Verbsky, Milwaukee, United States. In Curr Opin Rheumatol, 2012
Further study of well defined monogenic causes of inflammatory diseases, such as FMF, PAPA, TRAPS, and HIDS, has elucidated the pathophysiology of these diseases leading to targeted immunotherapy with anticytokine biological medications.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
GeneRIF
Fernandez-Zapico et al., Rochester, United States. In J Biol Chem, 2012
AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
GeneRIF
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus].
GeneRIF
Jin et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No expression of GLI3 gene was detected in the flexor hallucis longus of ICTEV patients or normal controls.
mRNA expression signature of Gleason grade predicts lethal prostate cancer.
Impact
Mucci et al., Boston, United States. In J Clin Oncol, 2011
PATIENTS AND METHODS: Using the complementary DNA-mediated annealing, selection, extension, and ligation assay, we measured the mRNA expression of 6,100 genes in prostate tumor tissue in the Swedish Watchful Waiting cohort (n = 358) and Physicians' Health Study (PHS; n = 109).
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Impact
Attié-Bitach et al., Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.
Impact
GeneRIF
Zeller et al., Utrecht, Netherlands. In Science, 2002
genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development
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