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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Feb 2015.

GLI family zinc finger 3

Gli3, PHS, ACLS, PAPA
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Gli, Shh
Papers using Gli3 antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Supplier
Grzeschik Karl-Heinz et al., In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on Gli3
Novel GLI3 mutation in a Greek-Cypriot patient with Greig cephalopolysyndactyly syndrome.
New
Kleopa et al., Nicosia, Cyprus. In Clin Dysmorphol, 23 Mar 2015
We report on a patient with GCPS caused by a novel GLI3 mutation.
Sonic Hedgehog pathway is up regulated in adamantinomatous craniopharyngiomas.
New
Antonini et al., Ribeirão Preto, Brazil. In Eur J Endocrinol, 18 Mar 2015
Patients & Methods: In 18 aCP samples, CTNNB1 was sequenced, and the mRNA expression levels of SHH pathway members (SHH, PTCH1, SMO, GLI1, GLI2, GLI3 and SUFU) and SMO, GLI1, GLI3, SUFU, beta-catenin, and Ki67 proteins were evaluated by qPCR and immunohistochemistry, respectively.
Pyoderma gangrenosum, acne and ulcerative colitis in a patient with a novel mutation in the PSTPIP1 gene.
New
Sprecher et al., Tel Aviv-Yafo, Israel. In Clin Exp Dermatol, 16 Mar 2015
BACKGROUND: Pyogenic sterile arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare hereditary, autosomal dominant, auto-inflammatory disease caused by mutations in the PSTPIP1 gene, which encodes proline-serine-threonine phosphatase interacting protein 1.
Dietary polyherbal supplementation decreases CD3(+) cell infiltration into pancreatic islets and prevents hyperglycemia in nonobese diabetic mice.
New
Jason Collier et al., Knoxville, United States. In Nutr Res, 27 Jan 2015
The mice consumed isocaloric matched diets without (controls) and with polyherbal supplementation (PHS) ad libitum starting at a prediabetic stage (age 6 weeks) for 12 weeks.
A novel GLI3c.750delC truncation mutation in a multiplex Greig cephalopolysyndactyly syndrome family with an unusual phenotypic combination in a patient.
New
Ali et al., Benares, India. In Meta Gene, Dec 2014
GCPS is known to be caused by mutations in the transcription factor GLI3 gene (7p13) which results in functional haploinsufficiency of this gene.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
New
Impact
Leung et al., San Diego, United States. In Nat Genet, Jun 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mutant PTEN in Cancer: Worse Than Nothing.
New
Impact
den Hertog et al., Utrecht, Netherlands. In Cell, May 2014
Papa et al.
A translational approach to congenital non-obstructive hydronephrosis.
Review
Rosenblum et al., Toronto, Canada. In Pediatr Nephrol, 2013
Recent data demonstrate that hedgehog signaling plays a critical role in regulating the structure and function of the collecting system in a manner dependent on the formation of GLI3 repressor.
[Sonic Hedgehog signaling pathway and regulation of inner ear development].
Review
Cao et al., Nanjing, China. In Yi Chuan, 2013
In humans, diseases accompanied by hearing disorders caused by abnormal Shh signaling include Greig cephalopolysyndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS), Waardenburg syndrome (WS) and medulloblastoma, etc.
Monogenic autoinflammatory diseases: concept and clinical manifestations.
Review
Goldbach-Mansky et al., Bethesda, United States. In Clin Immunol, 2013
The autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary "periodic fever syndromes", familial Mediterranean Fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency.
Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues.
Review
Cantarini et al., Padova, Italy. In Int J Rheumatol, 2012
To date, there are twelve known MAISs: familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, familial cold urticaria syndrome, Muckle-Wells syndrome, CINCA syndrome, mevalonate kinase deficiency, NLRP12-associated autoinflammatory disorder, Blau syndrome, early-onset sarcoidosis, PAPA syndrome, Majeed syndrome, and deficiency of the interleukin-1 receptor antagonist.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Monogenic causes of inflammatory disease in rheumatology.
Review
Verbsky, Milwaukee, United States. In Curr Opin Rheumatol, 2012
Further study of well defined monogenic causes of inflammatory diseases, such as FMF, PAPA, TRAPS, and HIDS, has elucidated the pathophysiology of these diseases leading to targeted immunotherapy with anticytokine biological medications.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
GeneRIF
Fernandez-Zapico et al., Rochester, United States. In J Biol Chem, 2012
AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
GeneRIF
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus].
GeneRIF
Jin et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No expression of GLI3 gene was detected in the flexor hallucis longus of ICTEV patients or normal controls.
mRNA expression signature of Gleason grade predicts lethal prostate cancer.
Impact
Mucci et al., Boston, United States. In J Clin Oncol, 2011
PATIENTS AND METHODS: Using the complementary DNA-mediated annealing, selection, extension, and ligation assay, we measured the mRNA expression of 6,100 genes in prostate tumor tissue in the Swedish Watchful Waiting cohort (n = 358) and Physicians' Health Study (PHS; n = 109).
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Impact
Attié-Bitach et al., Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.
Impact
GeneRIF
Zeller et al., Utrecht, Netherlands. In Science, 2002
genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development
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