gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

GLI family zinc finger 3

Gli3, PHS, ACLS, PAPA
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Gli, Shh
Papers using Gli3 antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Supplier
Grzeschik Karl-Heinz et al., In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on Gli3
Glioma-associated oncogene-2 is essential for trophoblastic fusion by forming a transcriptional complex with Glial cell missing-a.
New
Wu et al., Tokyo, Japan. In J Biol Chem, 14 Feb 2016
Moreover, among Glioma-associated oncogene (GLI) family transcriptional factors in Hedgehog signaling, knockdown of GLI2 but not GLI1 and GLI3 significantly attenuated Hedgehog-induced cell fusion, whereas overexpression of GLI2 activator alone was sufficient to induce cell fusion.
Expression pattern of the Hedgehog signaling pathway in pituitary adenomas.
New
Yovos et al., Thessaloníki, Greece. In Neurosci Lett, 12 Feb 2016
We used a customized RT(2) Profiler PCR Array, to investigate the expression of genes related to Notch and Hedgehog signaling pathways (PTCH1, PTCH2, GLI1, GLI3, NOTCH3, JAG1, HES1, and HIP).
MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3.
New
He et al., Shanghai, China. In Oncotarget, 10 Feb 2016
Moreover, we demonstrated that GLI3 was a direct target of miR-133b and the expression of Cyclin B1 and Cyclin D1 was enhanced by miR-133b mimics but decreased by its inhibitors.
The early history of Pallister-Hall syndrome-Buried treasure of a sort.
New
Hall, Canada. In Gene, 05 Feb 2016
Shortly after familial cases were recognized, the responsible gene was identified at GLI3.
Identification of markers linked to genes for sprouting tolerance (independent of grain color) in hard white winter wheat (HWWW).
New
Baenziger et al., Lincoln, United States. In Theor Appl Genet, 19 Jan 2016
Pre-harvest sprouting (PHS) of wheat (Triticum aestivum L.) can negatively impact end-use quality and seed viability at planting.
Binding small molecules and ions to [Fe4S4Cl4](2-) modulates rate of protonation of the cluster.
New
Henderson et al., Karbalā', Iraq. In Dalton Trans, 14 Jan 2016
UNASSIGNED: The mechanism of the acid-catalyzed substitution reaction of the terminal chloro-ligands in [Fe4S4Cl4](2-) by PhS(-) in the presence of NHBu(n)3(+) involves rate-limiting proton transfer from NHBu(n)3(+) to the cluster (k0 = 490 ± 20 dm(3) mol(-1) s(-1)).
Novel KIF7 Mutation in a Tunisian Boy with Acrocallosal Syndrome: Case Report and Review of the Literature.
New
Hoffjan et al., Bochum, Germany. In Mol Syndromol, Oct 2015
Acrocallosal syndrome (ACLS) is a rare autosomal recessive disorder characterized by agenesis of the corpus callosum, facial dysmorphism, postaxial polydactyly of the hands as well as preaxial polydactyly of the feet, and developmental delay.
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
New
Impact
Baudino et al., Saint-Étienne, France. In Science, Aug 2015
Monoterpenes represent up to 70% percent of the scent content in some cultivars, such as the Papa Meilland rose.
Dinitrosyl iron complexes (DNICs): from biomimetic synthesis and spectroscopic characterization toward unveiling the biological and catalytic roles of DNICs.
New
Impact
Liaw et al., Taiwan. In Acc Chem Res, May 2015
In addition, Fe/S K-edge X-ray absorption spectroscopy of tetrahedral DNICs deduced the qualitative assignment of Fe/NO oxidation states of {Fe(NO)2}(9) DNICs as a resonance hybrid of {Fe(II)((•)NO)(NO(-))}(9) and {Fe(III)(NO(-))2}(9) electronic states; the quantitative NO oxidation states of [(PhS)3Fe(NO)](-), [(PhS)2Fe(NO)2](-), and [(PhO)2Fe(NO)2](-) were further achieved by newly developed valence to core Fe Kβ X-ray emission spectroscopy as -0.58 ± 0.18, -0.77 ± 0.18, and -0.95 ± 0.18, respectively.
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.
Athar et al., Mobile, United States. In Cancers (basel), 2014
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3.
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
He et al., Shenzhen, China. In Nat Commun, 2014
Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2.
A genome-wide association study of growth trait-related single nucleotide polymorphisms in Chinese Yancheng chickens.
Chen et al., Yancheng, China. In Genet Mol Res, 2014
Four genes (FAM184B, KCNIP4, MIR15A, and GLI3) were closely associated with body weight.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Impact
Leung et al., San Diego, United States. In Nat Genet, 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mutant PTEN in Cancer: Worse Than Nothing.
Impact
den Hertog et al., Utrecht, Netherlands. In Cell, 2014
Papa et al.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
GeneRIF
Fernandez-Zapico et al., Rochester, United States. In J Biol Chem, 2012
AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
GeneRIF
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus].
GeneRIF
Jin et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No expression of GLI3 gene was detected in the flexor hallucis longus of ICTEV patients or normal controls.
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Impact
Attié-Bitach et al., Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
share on facebooktweetadd +1mail to friends