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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

GLI family zinc finger 3

Gli3, PHS, ACLS, PAPA
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Gli, Shh
Papers using Gli3 antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Supplier
Grzeschik Karl-Heinz et al., In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on Gli3
Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.
New
Studer et al., New York City, United States. In J Neurosci, 19 Sep 2015
Using pharmacological and genetic strategies, we demonstrate that early RA treatment directs MN differentiation independently of extrinsic SHH activation by suppressing the induction of GLI3.
A system-wide approach from the community to the hospital for improving neurologic outcomes in out-of-hospital cardiac arrest patients.
New
Lee et al., Seoul, South Korea. In Eur J Emerg Med, 11 Sep 2015
In 2011, compression-only cardiopulmonary resuscitation (CPR) for citizens, a state-wide standard dispatcher assisted-CPR protocol, medical control for regional emergency medical service (EMS), provision of high-quality advanced cardiac life support (ACLS) with capnography and extracorporeal CPR, and the standard postcardiac arrest care protocol were implemented in the system-wide CPR program.
p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.
New
Walterhouse et al., Chicago, United States. In Dna Repair (amst), 01 Sep 2015
We showed that TAF9 interacts with the oncogenic GLI family members GLI1 and GLI2 but not GLI3 in cell-free pull-down assays and with GLI1 in rhabdomyosarcoma and osteosarcoma cell lines.
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
New
Impact
Baudino et al., Saint-Étienne, France. In Science, 03 Aug 2015
Monoterpenes represent up to 70% percent of the scent content in some cultivars, such as the Papa Meilland rose.
GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.
New
Robbins et al., Miami, United States. In Ebiomedicine, Jun 2015
In particular, expression of the HEDGEHOG pathway component, GLI3, in female placentae was both negatively associated with arsenic exposure and positively associated with infant birth weight.
Dinitrosyl iron complexes (DNICs): from biomimetic synthesis and spectroscopic characterization toward unveiling the biological and catalytic roles of DNICs.
New
Impact
Liaw et al., Taiwan. In Acc Chem Res, May 2015
In addition, Fe/S K-edge X-ray absorption spectroscopy of tetrahedral DNICs deduced the qualitative assignment of Fe/NO oxidation states of {Fe(NO)2}(9) DNICs as a resonance hybrid of {Fe(II)((•)NO)(NO(-))}(9) and {Fe(III)(NO(-))2}(9) electronic states; the quantitative NO oxidation states of [(PhS)3Fe(NO)](-), [(PhS)2Fe(NO)2](-), and [(PhO)2Fe(NO)2](-) were further achieved by newly developed valence to core Fe Kβ X-ray emission spectroscopy as -0.58 ± 0.18, -0.77 ± 0.18, and -0.95 ± 0.18, respectively.
A common immunopathogenesis mechanism for infectious diseases: the protein-homeostasis-system hypothesis.
Review
New
Lee, Seoul, South Korea. In Infect Chemother, Mar 2015
The author proposes that this network is controlled by the protein homeostasis system (PHS), and that the immune system is one part of the PHS of the host.
Pallister-Hall syndrome has gone the way of modern medical genetics.
Review
New
Hall, In Am J Med Genet C Semin Med Genet, Dec 2014
Genotype/phenotype correlations have led to fine mapping of GLI3 and the recognition that PHS is caused by dominant negative mutations in the middle third of the gene.
Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy.
Review
New
Ruiz I Altaba et al., Salzburg, Austria. In Semin Cell Dev Biol, Sep 2014
In humans, the three GLI factors encode context-dependent activities with GLI1 being mostly an activator and GLI3 often a repressor.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
New
Impact
Leung et al., San Diego, United States. In Nat Genet, Jun 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mutant PTEN in Cancer: Worse Than Nothing.
New
Impact
den Hertog et al., Utrecht, Netherlands. In Cell, May 2014
Papa et al.
A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds.
Kim et al., Ch'ŏngju, South Korea. In J Anim Sci Technol, 2013
We have identified a set of candidate genes under selection and have known to be involved in growth, size and pork quality (CART, AGL, CF7L2, MAP2K5, DLK1, GLI3, CA3 and MC3R), ear morphology and size (HMGA2 and SOX5) stress response (ATF2, MSRB3, TMTC3 and SCAF8) and immune response ( HCST and RYR1).
[Sonic Hedgehog signaling pathway and regulation of inner ear development].
Review
Cao et al., Nanjing, China. In Yi Chuan, 2013
In humans, diseases accompanied by hearing disorders caused by abnormal Shh signaling include Greig cephalopolysyndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS), Waardenburg syndrome (WS) and medulloblastoma, etc.
Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues.
Review
Cantarini et al., Padova, Italy. In Int J Rheumatol, 2012
To date, there are twelve known MAISs: familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, familial cold urticaria syndrome, Muckle-Wells syndrome, CINCA syndrome, mevalonate kinase deficiency, NLRP12-associated autoinflammatory disorder, Blau syndrome, early-onset sarcoidosis, PAPA syndrome, Majeed syndrome, and deficiency of the interleukin-1 receptor antagonist.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
GeneRIF
Fernandez-Zapico et al., Rochester, United States. In J Biol Chem, 2012
AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
GeneRIF
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus].
GeneRIF
Jin et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No expression of GLI3 gene was detected in the flexor hallucis longus of ICTEV patients or normal controls.
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Impact
Attié-Bitach et al., Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
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