GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
GLI family zinc finger 3
Gli3, PHS, ACLS, PAPA
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
Gli3
antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Supplier
In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on
Gli3
Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma.
New
South Korea. In J Clin Pathol, 01 Apr 2013
RESULTS: HRSs were diffusely positive for GLI3, fascin and TUBB3; the mean positivity rates per case were 94% for GLI3, 82% for fascin, 69% for TUBB3, 17% for clusterin, 17% for γ-synuclein and 14% for syntenin.
Normal exon copy number of the GLI2 and GLI3 genes in patients with esophageal atresia.
New
Wrocław, Poland. In Dis Esophagus, 26 Mar 2013
Knockout studies in mice indicate that genes like Sonic hedgehog, Gli2, and Gli3 play a role in the etiology of EA.
Identification of a Homozygous PSTPIP1 Mutation in a Patient With a PAPA-Like Syndrome Responding to Canakinumab Treatment.
New
In Jama Dermatol, 01 Mar 2013
BACKGROUND Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome (OMIM 604416) is a rare autosomal dominant inherited autoinflammatory syndrome characterized by pyogenic sterile arthritis and less frequently accompanied by pyoderma gangrenosum and acne.
The Microarray Gene Profiling Analysis of Glioblastoma Cancer Cells Reveals Genes Affected by Fak Inhibitor Y15 and Combination of Y15 and Temozolomide.
New
Buffalo, United States. In Anticancer Agents Med Chem, 24 Feb 2013
Among genes up-regulated by Y15 and temozolomide more significantly than by each agent alone were: COX7B; interferon, gamma-inducible transcript: IFI16; DDIT4; GADD45G and down-regulated: KIF3A, AKT1; ABL; JAK1, GLI3 and ALDH1A3.
Pleiotropic Roles of uvrY on Biofilm Formation, Motility and Virulence in Uropathogenic Escherichia coli CFT073.
New
College Park, United States. In Plos One, Dec 2012
Furthermore, transcription of virulence specific genes such as papA, hlyB and galU was also reduced in the deletion mutant.
Monogenic causes of inflammatory disease in rheumatology.
Review
New
Milwaukee, United States. In Curr Opin Rheumatol, Sep 2012
Further study of well defined monogenic causes of inflammatory diseases, such as FMF, PAPA, TRAPS, and HIDS, has elucidated the pathophysiology of these diseases leading to targeted immunotherapy with anticytokine biological medications.
Interleukin-1, inflammasomes, autoinflammation and the skin.
Review
Zürich, Switzerland. In Swiss Med Wkly, 2011
In mouse models recapitulating mutations observed in CAPS, neutrophilic inflammation of the skin is a cardinal feature, in a manner similar to several autoinflammatory diseases with skin involvement such as PAPA (pyoderma gangrenosum, acne and pyogenic arthritis) and Schnitzler's syndrome, in which IL-1β very probably plays a pathogenic role.
Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.
GeneRIF
Chicago, United States. In Dev Biol, 2011
Data show that in Shh;Gli3 mutants, adjacent rings of Fgf8 and Wnt3a expression are induced in the diencephalon at the ZLI, reminiscent of the Fgf8/Wnt1-expressing isthmic organizer.
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.
GeneRIF
Evanston, United States. In J Biol Chem, 2011
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.
Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
GeneRIF
Houston, United States. In Hum Pathol, 2011
GLI3 is strongly expressed by virtually 100% of the Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
[Autoinflammatory diseases as cause of wound healing defects].
Review
Köln, Germany. In Hautarzt, 2011
In this article we will focus on the review of those autoinflammatory diseases that often display ulcerative cutaneous and aphthous lesions including pyoderma gangrenosum, Behçet disease, PAPA syndrome and hyperimmunoglobulinemia D with periodic fever syndrome (HIDS).
mRNA expression signature of Gleason grade predicts lethal prostate cancer.
Impact
Boston, United States. In J Clin Oncol, 2011
METHODS: Using the complementary DNA-mediated annealing, selection, extension, and ligation assay, we measured the mRNA expression of 6,100 genes in prostate tumor tissue in the Swedish Watchful Waiting cohort (n = 358) and Physicians' Health Study (PHS; n = 109).
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Impact
Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
Acne-associated syndromes: models for better understanding of acne pathogenesis.
Review
München, Germany. In J Eur Acad Dermatol Venereol, 2011
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation.
Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.
GeneRIF
Paris, France. In Development, 2011
Introduction of a Gli3 mutant allele encoding the short form of Gli3 into Ftm mutants rescues both telencephalic patterning and olfactory bulb morphogenesis, despite the persistence of cilia defects.
Gli3 is required for maintenance and fate specification of cortical progenitors.
GeneRIF
Bethesda, United States. In J Neurosci, 2011
Gli3 is required for maintaining the cortical progenitors in active cell cycle, suggesting that cells may acquire differentiated status as they turn off Gli3 expression during neurogenesis.
[Inflammasomes and related diseases].
Review
Kyoto, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2010
Genetic disorder of inflammasome-IL-1 system cause autoinflammatory diseases such as cryopyrin-associated autoinflammatory disease, familial Mediterranean fever, deficiency of IL-1 receptor antagonist, and PAPA syndrome.
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.
Impact
GeneRIF
Utrecht, Netherlands. In Science, 2002
genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
Impact
Toronto, Canada. In Nat Med, 1999
Although the mechanism of teratogenesis and determinants of risk remain unclear, related teratogenic xenobiotics are bioactivated by embryonic prostaglandin H synthase (PHS) to a free-radical intermediates that produce reactive oxygen species (ROS), which cause oxidative damage to DNA and other cellular macromolecules.
Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening.
Impact
Boston, United States. In Jama, 1997
METHODS: Survey of 4047 American men and women participating in the Physicians' Health Study (PHS) or in the Women's Health Study (WHS).
