GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
GLI family zinc finger 1
Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from
NCBI)
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Papers using
Gli
antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Supplier
In PLoS ONE, 2010
Basic mechanism of eukaryotic chromosome segregation
Supplier
In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Supplier
In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Supplier
In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
more suppliersSupplier
In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
Papers on
Gli
Proteomic Analysis and Molecular Modeling Characterize the Iron-Regulatory Protein, Hemojuvelin/Repulsive Guidance Molecule c.
New
In Biochem J, 06 Apr 2013
Here we have mapped the disulfide bonds in mouse HJV/RGMc using a proteomics strategy combining sequential mass spectrometry (MS) steps composed of electron transfer dissociation (ETD) and collision-induced dissociation (CID), in which ETD induces cleavage of disulfide linkages, and CID establishes disulfide bond assignments between liberated peptides.
Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma.
New
South Korea. In J Clin Pathol, 01 Apr 2013
We investigated the expression of several FDC markers in HL and anaplastic large cell lymphoma (ALCL) and evaluated their diagnostic efficacy.
The role of hematopoietic stem cell transplantation in SP110 associated veno-occlusive disease with immunodeficiency syndrome.
New
Jerusalem, Israel. In Pediatr Allergy Immunol, 01 Apr 2013
Hematopoietic stem cell transplantation (HSCT) - the only definitive treatment for CID - appeared to have a high rate of complications in a previous report.
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.
New
Impact
Stanford, United States. In Nature, 28 Mar 2013
Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI.
Cancer genetics and genomics of human FOX family genes.
Review
New
Tokyo, Japan. In Cancer Lett, 28 Feb 2013
FOXM1 is overexpressed owing to gene amplification in basal-type breast cancer and diffuse large B-cell lymphoma (DLBCL), and it is transcriptionally upregulated owing to Hedgehog-GLI, hypoxia-HIF1α or YAP-TEAD signaling activation.
Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway.
New
Xi'an, China. In Pharmazie, 28 Feb 2013
Mechanically, treatment of RCC cells with zerumbone activated caspase-3 and caspase-9, and finally led to cleavage of PARR In addition, downregulation of Gli-1 and Bcl-2, which were closely related to the chemoresistance of RCC, was observed in zerumbone-treated RCC cells.
Transcription in the maintenance of centromere chromatin identity.
Review
New
Australia. In Nucleic Acids Res, Dec 2012
However, non-siRNA transcripts emanating from both pericentric and centromere core domains have also been detected in a cell cycle and cellular differentiation-dependent manner.
An Efficient Dynamic Programming Algorithm for Phosphorylation Site Assignment of Large-Scale Mass Spectrometry Data.
New
Bethesda, United States. In Proceedings (ieee Int Conf Bioinformatics Biomed), Nov 2012
The algorithm is tested using experimentally generated data sets of peptides with known phosphorylation sites while varying the fragmentation strategy (CID or HCD) and molar amounts of the peptides.
The split personality of CENP-A nucleosomes.
New
Impact
Stanford, United States. In Cell, Aug 2012
Two independent studies in this issue, in yeast and human cells, now suggest that CENP-A nucleosomes adopt different structures depending on the stage of the cell cycle.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
New
Impact
Bethesda, United States. In Cell, Aug 2012
We tested this hypothesis by tracking CENP-A nucleosomal components, structure, chromatin folding, and covalent modifications across the human cell cycle.
The CENP-A nucleosome: a dynamic structure and role at the centromere.
Review
New
Bethesda, United States. In Chromosome Res, Jul 2012
The specific centromere histone H3 variant CENP-A has been described as the epigenetic mark of this chromatin region.
HACking the centromere chromatin code: insights from human artificial chromosomes.
Review
New
United States. In Chromosome Res, Jul 2012
At the centromere, CENP-A nucleosomes form part of a chromatin landscape termed centrochromatin.
The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease.
Review
New
Changsha, China. In Pharmazie, Jun 2012
Recent studies show that up-regulated expression of hypoxia-induced factor-1 (HIF-1) and inflamemation in ischemic tissues activate the Hh signaling cascade in a GLI-dependent or independent way, resulting in elevated expression levels of pro-angiogenic and agiogenic factors to facilitate angiogenesis.
An inverse relationship to germline transcription defines centromeric chromatin in C. elegans.
New
Impact
San Diego, United States. In Nature, May 2012
The histone H3 variant CENP-A (also known as CenH3) defines centromeres in monocentric organisms, which confine centromere activity to a discrete chromosomal region, and holocentric organisms, which distribute centromere activity along the chromosome length.
A new histone at the centromere?
New
Impact
Charlottesville, United States. In Cell, Mar 2012
The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly.
Hepatitis B virus X protein mutant upregulates CENP-A expression in hepatoma cells.
GeneRIF
Shanghai, China. In Oncol Rep, 2012
overexpression of CENP-A is closely associated with hepatitis B virus x protein COOH mutation in hepatocellular carcinoma
Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.
GeneRIF
Syracuse, United States. In Development, 2011
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
CENP-A exceeds microtubule attachment sites in centromere clusters of both budding and fission yeast.
GeneRIF
Columbus, United States. In J Cell Biol, 2011
The results suggest that the number of CENP-A molecules exceeds the number of kinetochore-microtubule (MT) attachment sites on each chromosome and that CENP-A is not the sole determinant of kinetochore assembly sites in Schizosaccharomyces pombe.
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.
GeneRIF
Evanston, United States. In J Biol Chem, 2011
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.
Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.
More papers using
Gli
antibodies
GeneRIF
Shanghai, China. In Hepatogastroenterology, 2011
Hh pathway is aberrant activation in colorectal carcinoma cell line. Its inhibitor may be effectual agent for colorectal cancer chemoprevention. Gli1 maintained cell survival by binding promoter regions and facilitating transcription of IGFBP6 and Bcl-2.
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Supplier
In The Journal of Cell Biology, 2000
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Supplier
In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Supplier
In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
