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GLI family zinc finger 1

Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, Shh, Smo, Histone
Papers using Gli antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Supplier
Xie Jingwu, In PLoS ONE, 2010
... Antibodies against GAPDH and Gli were purchased from Cell Signaling Technology, Inc ...
Basic mechanism of eukaryotic chromosome segregation
Supplier
Nigg Erich A. et al., In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Supplier
Massfelder Thierry et al., In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Supplier
Vale Ronald D. et al., In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
Supplier
Karnitz Larry M. et al., In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
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Papers on Gli
Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca(2+) levels.
New
Ge et al., Shenyang, China. In Acta Pharmacol Sin, 13 May 2015
However, IMT, 4-AP, and Gli did not inhibit ECH-induced relaxation.
Sonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro.
New
Yang et al., Chongqing, China. In Cell Physiol Biochem, 30 Apr 2015
At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.
Characterization of the 12q Amplicons in Lipomatous Soft Tissue Tumors by Multiplex Ligation-dependent Probe Amplification-based Copy Number Analysis.
New
Ferdinande et al., Utrecht, Netherlands. In Anticancer Res, 30 Apr 2015
Moreover, we identified additional genes exclusively amplified in DDLPS in 12q13, 12q21 and 12q24, including glioma-associated oncogene homolog 1 (GLI1), mitogen activated protein kinase kinase kinase 12 (MAP3K12), cyclin-dependent kinase 2 (CDK2), ALX homeobox 1 (ALX1) and T-box 5 (TBX5).
Smoothened variants explain the majority of drug resistance in Basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, 09 Apr 2015
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms.
Germline and somatic mutations in meningiomas.
Review
New
Smith, Manchester, United Kingdom. In Cancer Genet, 19 Mar 2015
Recently, a second SWI/SNF complex subunit, SMARCE1, was identified as a cause of clear cell meningiomas, indicating a wider role for this complex in meningioma disease.
Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus.
New
Alvarez-Bolado et al., Heidelberg, Germany. In Front Neuroanat, Dec 2014
This balance-the Shh-Gli code-is species- and context-dependent and has been elucidated for the mouse spinal cord.
Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
New
Zheng et al., Xi'an, China. In Cell Death Dis, Dec 2014
Together, these results show that PCAF can induce cell apoptosis by modulating a GLI1/Bcl-2/BAX axis that in turn suppresses HCC progression, and suggest that 5-FU may exert a stronger anti-tumor effect in patients with PCAF expression in HCC tumors.
The centromere: chromatin foundation for the kinetochore machinery.
Review
New
Earnshaw et al., Mishima, Japan. In Dev Cell, Oct 2014
Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
New
Impact
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
By bypassing these regulated steps, we uncoupled CENP-A deposition from cell-cycle progression, resulting in mitotic defects.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
New
Impact
Cho et al., Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Kif7 keeps cilia tips in shape.
New
Impact
Akhmanova et al., Copenhagen, Denmark. In Nat Cell Biol, Jul 2014
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors.
Centromeric heterochromatin: the primordial segregation machine.
Impact
Bloom, Chapel Hill, United States. In Annu Rev Genet, 2013
Centromeric heterochromatin is characterized by specific histone modifications, a centromere-specific histone H3 variant (CENP-A), and the enrichment of cohesin, condensin, and topoisomerase II.
Sonic hedgehog signaling in the development of the mouse hypothalamus.
Review
Álvarez-Bolado et al., Bonn, Germany. In Front Neuroanat, 2013
To further elucidate the role of Shh in hypothalamic development, it will be essential to understand how Shh regulates the downstream Gli transcription factors.
Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis.
Review
Fernandez-Zapico et al., Rochester, United States. In F1000res, 2013
Aberrant activation of the transcription factor GLI1, a central effector of the Hedgehog (HH) pathway, is associated with several malignancies, including pancreatic ductal adenocarcinoma (PDAC), one of most deadly human cancers.
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.
GeneRIF
Zhang et al., Hangzhou, China. In Lung Cancer, 2012
Our results demonstrate that elevated CENP-A expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
Impact
GeneRIF
Dalal et al., Bethesda, United States. In Cell, 2012
Whereas canonical H3 nucleosomes have octameric dimensions throughout the cell cycle, CENP-A nucleosomes are predominantly tetramers in early G1 phase, alter to octamers at the end of G1 through S phase, and revert to tetramers after replication.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
GeneRIF
Chung et al., Tokyo, Japan. In J Biol Chem, 2012
upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis.
[Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma].
GeneRIF
Liu et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Gli1 is up-regulated in hepatocellular carcinoma tissues
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer.
GeneRIF
Luo et al., Jinan, China. In Int J Med Sci, 2011
In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.
Nanoanalysis of the arthropod neuro-toxins.
Review
Nakajima, Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
Venom profiles are screened by MALDI-TOF fingerprinting analysis prior to purification of venomous components, then marked target toxins of small molecular mass (1000-5000) are characterized directly by means of mass spectrometric techniques such as Frit-FAB MS/MS, CID/PSD-TOF MS, Capil.-HPLC/Q-TOF
More papers using Gli antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Supplier
Zachos George et al., In The Journal of Cell Biology, 2000
... (ab3792) was purchased from Millipore, polyclonal phospho–CENP-A (Ser7) antibody was purchased from Cell Signaling Technology, and polyclonal antibody ...
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Supplier
Ruiz i Altaba Ariel et al., In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Supplier
McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
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