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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

GLI family zinc finger 1

Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, Shh, Smo, V1a
Papers using Gli antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Xie Jingwu, In PLoS ONE, 2010
... Antibodies against GAPDH and Gli were purchased from Cell Signaling Technology, Inc ...
Basic mechanism of eukaryotic chromosome segregation
Nigg Erich A. et al., In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Massfelder Thierry et al., In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Vale Ronald D. et al., In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
Karnitz Larry M. et al., In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
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Papers on Gli
The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis.
Liu et al., Xuzhou, China. In Inflammation, 09 Dec 2015
Our results suggest that SHH-Gli pathway is involved in the pathogenesis of RA, and blocking SHH-Gli pathway inhibits RA-SF cell proliferation and increases cell apoptosis, which may shed light on developing new ideas for RA treatment.
GLI1 expression is an important prognostic factor that contributes to the poor prognosis of rhabdomyosarcoma.
Li et al., Shihezi, China. In Histol Histopathol, 06 Dec 2015
UNASSIGNED: The GLI1 and MDM2 genes are amplified or exhibit copy number gains in rhabdomyosarcoma (RMS).
N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons.
Kim et al., Bethesda, United States. In Biol Open, 06 Dec 2015
We found that synaptamide increased the average axon length, inhibited GLI family zinc finger 1 (GLI1) transcription and sonic hedgehog (Shh) target gene expression while inducing cAMP elevation.
Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes.
Roskoski, United States. In Pharmacol Res, 01 Dec 2015
Chemical compounds studied in this article: Afatinib (PubMed CID: 10,184,653), Crizotinib (PubMed CID:), Erlotinib (PubMed CID: 176,870), Gefitinib (PubMed CID: 123,631), Imatinib (PubMed CID: 5291), Nilotinib (PubMed CID: 644,241), Sorafinib (PubMed CID: 216,239), Sunitinib (PubMed CID: 5,329,102); Tofacitinib (PubMed CID: 9,926,791); Vemurafenib (PubMed CID: 42,611,257).
Anti-centromere protein A antibodies in systemic sclerosis: Significance and origin.
Valentini et al., Bari, Italy. In Autoimmun Rev, 08 Nov 2015
About 20%-40% of patients have antibodies to centromere protein (CENP)-A or -B.
Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.
Wu et al., Dortmund, Germany. In Curr Opin Chem Biol, 31 Oct 2015
Chemically induced dimerization (CID) has been used as a valuable tool to study various biological processes.
Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.
Heck et al., Utrecht, Netherlands. In Nat Methods, 28 Oct 2015
Our approach is based on the application of mass spectrometry (MS)-cleavable cross-linkers, sequential collision-induced dissociation (CID)-tandem MS (MS/MS) and electron-transfer dissociation (ETD)-MS/MS acquisitions, and a dedicated search engine, XlinkX, which allows rapid cross-link identification against a complete human proteome database.
Mitogen-Activated Protein Kinases and Hedgehog-GLI signaling in cancer: a crosstalk providing therapeutic opportunities?
Stecca et al., Florence, Italy. In Semin Cancer Biol, Sep 2015
UNASSIGNED: The Hedgehog-GLI (HH-GLI) signaling is of critical importance during embryonic development, where it regulates a number of cellular processes, including patterning, proliferation and differentiation.
Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.
Earnshaw, Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, Jul 2015
Inner kinetochore proteins associate with specialized centromeric chromatin containing the histone H3 variant centromere protein A (CENP-A) in place of H3.
Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.
Gutkind et al., Bethesda, United States. In Nat Cell Biol, Jun 2015
Mechanistically, we found that Gαs-PKA disruption promotes the cell autonomous Sonic Hedgehog pathway stimulation and Hippo signalling inhibition, resulting in the non-canonical activation of GLI and YAP1.
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
Black et al., Philadelphia, United States. In Science, Jun 2015
A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms.
Sonic Hedgehog Signaling: Evidence for Its Protective Role in Endotoxin Induced Acute Lung Injury in Mouse Model.
Wang et al., Jinan, China. In Plos One, Dec 2014
mRNA expression levels of TNF-α, SHH, Patched (PTC) and GLI1 in lung tissue were studied with real time quantitative PCR (RT-PCR), while the protein expression of SHH and GLI1 was determined by western blot analysis.
Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer.
Antonarakis et al., Baltimore, United States. In Cancers (basel), Dec 2014
Activity in the Hedgehog pathway, which regulates GLI-mediated transcription, is important in organogenesis and stem cell regulation in self-renewing organs, but is pathologically elevated in many human malignancies.
LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration.
Gao et al., Jinan, China. In Sci Rep, Dec 2014
The Liver Kinase B1 (LKB1) gene plays crucial roles in cell differentiation, proliferation and the establishment of cell polarity.
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.
Zhang et al., Hangzhou, China. In Lung Cancer, 2012
Our results demonstrate that elevated CENP-A expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
Dalal et al., Bethesda, United States. In Cell, 2012
Whereas canonical H3 nucleosomes have octameric dimensions throughout the cell cycle, CENP-A nucleosomes are predominantly tetramers in early G1 phase, alter to octamers at the end of G1 through S phase, and revert to tetramers after replication.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
Chung et al., Tokyo, Japan. In J Biol Chem, 2012
upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis.
[Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma].
Liu et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Gli1 is up-regulated in hepatocellular carcinoma tissues
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer.
Luo et al., Jinan, China. In Int J Med Sci, 2011
In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.
More papers using Gli antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Zachos George et al., In The Journal of Cell Biology, 2000
... (ab3792) was purchased from Millipore, polyclonal phospho–CENP-A (Ser7) antibody was purchased from Cell Signaling Technology, and polyclonal antibody ...
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Ruiz i Altaba Ariel et al., In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
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