Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoremore suppliers
In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere.
Columbus, United States. In Dev Cell, 25 Mar 2015
UNASSIGNED: CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity to ensure kinetochore assembly and proper chromosome segregation, but the precise mechanism of its specific localization within centromeric heterochromatin remains obscure.
Apoptosis of beta cells in diabetes mellitus.
Hyderābād, India. In Dna Cell Biol, Nov 2014
The other gene products that are involved in diabetes are nitric oxide synthase-2 (NOS2), small ubiquitin-like modifier (SUMO), apolipoprotein CIII (ApoCIII), forkhead box protein O1 (FOXO1), and Kruppel-like zinc finger protein Gli-similar 3 (GLIS3).
Kif7 keeps cilia tips in shape.
Copenhagen, Denmark. In Nat Cell Biol, Jul 2014
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Mass spectrometry-driven phosphoproteomics: patterning the systems biology mosaic.
More papers using
Zürich, Switzerland. In Wiley Interdiscip Rev Dev Biol, 2014
Subsequent mass spectrometric analysis revolves around peptide ion fragmentation to generate sequence information and identify the backbone sequence of phosphopeptides as well as the phosphate group attachment site(s), and different modes of fragmentation like collision-induced dissociation (CID), electron transfer dissociation (ETD), and higher energy collisional dissociation (HCD) have been established for phosphopeptide analysis.