Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoremore suppliers
In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
The molecular basis for centromere identity and function.
Cambridge, United States. In Nat Rev Mol Cell Biol, Jan 2016
Most eukaryotic centromeres are defined epigenetically and require the presence of nucleosomes containing the histone H3 variant centromere protein A (CENP-A; also known as CENH3).
Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.
Utrecht, Netherlands. In Nat Methods, Dec 2015
Our approach is based on the application of mass spectrometry (MS)-cleavable cross-linkers, sequential collision-induced dissociation (CID)-tandem MS (MS/MS) and electron-transfer dissociation (ETD)-MS/MS acquisitions, and a dedicated search engine, XlinkX, which allows rapid cross-link identification against a complete human proteome database.
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.
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Mobile, United States. In Cancers (basel), 2014
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3.