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GLI family zinc finger 1

Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, Shh, Smo, Histone
Papers using Gli antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Supplier
Xie Jingwu, In PLoS ONE, 2010
... Antibodies against GAPDH and Gli were purchased from Cell Signaling Technology, Inc ...
Basic mechanism of eukaryotic chromosome segregation
Supplier
Nigg Erich A. et al., In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Supplier
Massfelder Thierry et al., In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Supplier
Vale Ronald D. et al., In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
Supplier
Karnitz Larry M. et al., In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
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Papers on Gli
The use of ion mobility mass spectrometry to assist protein design: a case study on zinc finger fold versus coiled coil interactions.
New
Barran et al., Edinburgh, United Kingdom. In Analyst, 03 Apr 2015
With collision induced dissociation (CID), we probe complex stability, and establish that peptide-metal interactions are stronger and more 'specific' than those of peptide-peptide complexes, and the anticipated hetero-dimeric complex is more stable than the two homo-dimers.
Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin.
New
Allshire et al., Edinburgh, United Kingdom. In Plos Genet, 31 Mar 2015
UNASSIGNED: Centromere sequences are not conserved between species, and there is compelling evidence for epigenetic regulation of centromere identity, with location being dictated by the presence of chromatin containing the histone H3 variant CENP-A.
CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere.
New
Kitagawa et al., Columbus, United States. In Dev Cell, 25 Mar 2015
UNASSIGNED: CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity to ensure kinetochore assembly and proper chromosome segregation, but the precise mechanism of its specific localization within centromeric heterochromatin remains obscure.
Apoptosis of beta cells in diabetes mellitus.
Review
New
Rani et al., Hyderābād, India. In Dna Cell Biol, Nov 2014
The other gene products that are involved in diabetes are nitric oxide synthase-2 (NOS2), small ubiquitin-like modifier (SUMO), apolipoprotein CIII (ApoCIII), forkhead box protein O1 (FOXO1), and Kruppel-like zinc finger protein Gli-similar 3 (GLIS3).
[Investigation of self-renewal mechanism about CD133+ cancer stem cells in human laryngeal carcinoma Hep-2 cell line].
New
Wang et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Nov 2014
Self-renewal related gene such as β-catenin, SHH, SMOH and Bmi-1,Gli-1 were all up-regulated in CD133+ group both in mRNA and protein.
The centromere: chromatin foundation for the kinetochore machinery.
Review
New
Earnshaw et al., Mishima, Japan. In Dev Cell, Oct 2014
Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
New
Impact
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
By bypassing these regulated steps, we uncoupled CENP-A deposition from cell-cycle progression, resulting in mitotic defects.
Kif7 keeps cilia tips in shape.
New
Impact
Akhmanova et al., Copenhagen, Denmark. In Nat Cell Biol, Jul 2014
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors.
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
New
Impact
Anderson et al., New York City, United States. In Nat Cell Biol, Jul 2014
Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and the Gli-Sufu complexes that mediate Hh signalling, which are enriched at cilia tips.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
New
Impact
Cho et al., Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Mass spectrometry-driven phosphoproteomics: patterning the systems biology mosaic.
Review
Aebersold et al., Zürich, Switzerland. In Wiley Interdiscip Rev Dev Biol, 2014
Subsequent mass spectrometric analysis revolves around peptide ion fragmentation to generate sequence information and identify the backbone sequence of phosphopeptides as well as the phosphate group attachment site(s), and different modes of fragmentation like collision-induced dissociation (CID), electron transfer dissociation (ETD), and higher energy collisional dissociation (HCD) have been established for phosphopeptide analysis.
Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.
Herrera et al., Mexico. In Cell Div, 2013
The aim of this study was to determine whether alterations in the localization of HP1 proteins induced by trichostatin A (TSA) modify Mis12 and Centromere Protein A (CENP-A) recruitment to the centromere and whether changes in the expression of HP1 proteins and H3K9 methylation at centromeric chromatin increase CIN in HCT116 and WI-38 cells.
Centromeric heterochromatin: the primordial segregation machine.
Impact
Bloom, Chapel Hill, United States. In Annu Rev Genet, 2013
Centromeric heterochromatin is characterized by specific histone modifications, a centromere-specific histone H3 variant (CENP-A), and the enrichment of cohesin, condensin, and topoisomerase II.
Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis.
Review
Fernandez-Zapico et al., Rochester, United States. In F1000res, 2013
Aberrant activation of the transcription factor GLI1, a central effector of the Hedgehog (HH) pathway, is associated with several malignancies, including pancreatic ductal adenocarcinoma (PDAC), one of most deadly human cancers.
Sonic hedgehog signaling in the development of the mouse hypothalamus.
Review
Álvarez-Bolado et al., Bonn, Germany. In Front Neuroanat, 2013
To further elucidate the role of Shh in hypothalamic development, it will be essential to understand how Shh regulates the downstream Gli transcription factors.
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.
GeneRIF
Zhang et al., Hangzhou, China. In Lung Cancer, 2012
Our results demonstrate that elevated CENP-A expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
Impact
GeneRIF
Dalal et al., Bethesda, United States. In Cell, 2012
Whereas canonical H3 nucleosomes have octameric dimensions throughout the cell cycle, CENP-A nucleosomes are predominantly tetramers in early G1 phase, alter to octamers at the end of G1 through S phase, and revert to tetramers after replication.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
GeneRIF
Chung et al., Tokyo, Japan. In J Biol Chem, 2012
upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis.
[Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma].
GeneRIF
Liu et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Gli1 is up-regulated in hepatocellular carcinoma tissues
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer.
GeneRIF
Luo et al., Jinan, China. In Int J Med Sci, 2011
In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.
More papers using Gli antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Supplier
Zachos George et al., In The Journal of Cell Biology, 2000
... (ab3792) was purchased from Millipore, polyclonal phospho–CENP-A (Ser7) antibody was purchased from Cell Signaling Technology, and polyclonal antibody ...
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Supplier
Ruiz i Altaba Ariel et al., In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Supplier
McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
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