Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoremore suppliers
In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Metabolites in vertebrate Hedgehog signaling.
Oslo, Norway. In Biochem Biophys Res Commun, May 2014
The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation.
"Atypical" regulation of Hedgehog-dependent cancers.
Stanford, United States. In Cancer Cell, Mar 2014
In this issue of Cancer Cell, Justilien and colleagues present the surprising finding that PKCι promotes Hedgehog ligand production and lung squamous cell carcinoma growth through SOX2, rather than the canonical transcription factor GLI.
Anarchic centromeres: deciphering order from apparent chaos.
Edinburgh, United Kingdom. In Curr Opin Cell Biol, Feb 2014
Specialised chromatin in which canonical histone H3 is replaced by CENP-A, an H3 related protein, is a signature of active centromeres and provides the foundation for kinetochore assembly.
Swapping CENP-A at the centromere.
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Stanford, United States. In Nat Cell Biol, Sep 2013
Faithful genome segregation depends on the functions of the eukaryotic centromere, which is characterized by the histone variant CENP-A.