Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoremore suppliers
In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
The presence of primary cilia in cancer cells does not predict responsiveness to modulation of smoothened activity.
Birmingham, United States. In Int J Oncol, 15 Jun 2015
To determine whether the presence or absence of primary cilia in cancer cells will predict their responsiveness to modulation of smoothened activity, we compared the ability of an agonist and/or inhibitor of smoothened (SAG and SANT1, respectively) to modulate GLI-mediated transcription, as measured by GLI1 mRNA level or GLI-luciferase reporter activity, in non-cancer cells with primary cilia (ovarian surface epithelial cells and breast fibroblasts), in cancer cells that cannot assemble primary cilia (MCF7, MDA-MB-231 cell lines), and in cancer cells with primary cilia (SKOV3, PANC1 cell lines).
Germline and somatic mutations in meningiomas.
Manchester, United Kingdom. In Cancer Genet, Mar 2015
Recently, a second SWI/SNF complex subunit, SMARCE1, was identified as a cause of clear cell meningiomas, indicating a wider role for this complex in meningioma disease.
Nanoanalysis of the arthropod neuro-toxins.
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Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
Venom profiles are screened by MALDI-TOF fingerprinting analysis prior to purification of venomous components, then marked target toxins of small molecular mass (1000-5000) are characterized directly by means of mass spectrometric techniques such as Frit-FAB MS/MS, CID/PSD-TOF MS, Capil.-HPLC/Q-TOF