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GLI family zinc finger 1

Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, Shh, Smo, Histone
Papers using Gli antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Supplier
Xie Jingwu, In PLoS ONE, 2010
... Antibodies against GAPDH and Gli were purchased from Cell Signaling Technology, Inc ...
Basic mechanism of eukaryotic chromosome segregation
Supplier
Nigg Erich A. et al., In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Supplier
Massfelder Thierry et al., In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Supplier
Vale Ronald D. et al., In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
Supplier
Karnitz Larry M. et al., In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
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Papers on Gli
Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.
New
Gebhardt et al., Jena, Germany. In Mol Biosyst, 26 Jun 2015
UNASSIGNED: The GLI transcription factors, GLI1, GLI2, and GLI3, transduce Hedgehog and non-hedgehog signals and are involved in regulating development and tumorgenesis.
Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer.
New
Wei et al., Jinan, China. In Int J Mol Med, 21 Jun 2015
Furthermore, the small interfering RNA (siRNA)‑mediated downregulation of AMPK reversed the inhibitory effects of metformin on rhShh‑induced Gli-1 expression and stemness.
Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.
New
Impact
Earnshaw, Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, 20 Jun 2015
Inner kinetochore proteins associate with specialized centromeric chromatin containing the histone H3 variant centromere protein A (CENP-A) in place of H3.
The presence of primary cilia in cancer cells does not predict responsiveness to modulation of smoothened activity.
New
Frost et al., Birmingham, United States. In Int J Oncol, 15 Jun 2015
To determine whether the presence or absence of primary cilia in cancer cells will predict their responsiveness to modulation of smoothened activity, we compared the ability of an agonist and/or inhibitor of smoothened (SAG and SANT1, respectively) to modulate GLI-mediated transcription, as measured by GLI1 mRNA level or GLI-luciferase reporter activity, in non-cancer cells with primary cilia (ovarian surface epithelial cells and breast fibroblasts), in cancer cells that cannot assemble primary cilia (MCF7, MDA-MB-231 cell lines), and in cancer cells with primary cilia (SKOV3, PANC1 cell lines).
Inactivation of a Gαs-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.
New
Impact
Gutkind et al., Bethesda, United States. In Nat Cell Biol, 11 Jun 2015
Mechanistically, we found that Gαs-PKA disruption promotes the cell autonomous Sonic Hedgehog pathway stimulation and Hippo signalling inhibition, resulting in the non-canonical activation of GLI and YAP1.
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
New
Impact
Black et al., Philadelphia, United States. In Science, 08 Jun 2015
A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, 09 Apr 2015
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms.
Germline and somatic mutations in meningiomas.
Review
New
Smith, Manchester, United Kingdom. In Cancer Genet, Mar 2015
Recently, a second SWI/SNF complex subunit, SMARCE1, was identified as a cause of clear cell meningiomas, indicating a wider role for this complex in meningioma disease.
Serine effects on collision-induced dissociation and photodissociation of peptide cation radicals of the z (+•) -type.
New
Tureček et al., Madison, United States. In Int J Mass Spectrom, Mar 2015
Energy-resolved collision-induced dissociation (ER-CID), time-resolved infrared multiphoton dissociation (TR-IRMPD), and single-photon UV photodissociation at 355 nm revealed several competitive dissociation pathways consisting of loss of OH radical, water, and backbone cleavages occurring at N-terminal and C-terminal positions relative to the serine residue.
Surface induced dissociation yields substructure of Methanosarcina thermophila 20S proteasome complexes.
New
Wysocki et al., Columbus, United States. In Int J Mass Spectrom, Mar 2015
SID produces both α and β subunits while collision induced dissociation (CID) produces only highly charged α subunit.
The centromere: chromatin foundation for the kinetochore machinery.
Review
New
Earnshaw et al., Mishima, Japan. In Dev Cell, Oct 2014
Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery.
Sonic hedgehog signaling in the development of the mouse hypothalamus.
Review
Álvarez-Bolado et al., Bonn, Germany. In Front Neuroanat, 2013
To further elucidate the role of Shh in hypothalamic development, it will be essential to understand how Shh regulates the downstream Gli transcription factors.
Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis.
Review
Fernandez-Zapico et al., Rochester, United States. In F1000res, 2013
Aberrant activation of the transcription factor GLI1, a central effector of the Hedgehog (HH) pathway, is associated with several malignancies, including pancreatic ductal adenocarcinoma (PDAC), one of most deadly human cancers.
Centromeric heterochromatin: the primordial segregation machine.
Impact
Bloom, Chapel Hill, United States. In Annu Rev Genet, 2013
Centromeric heterochromatin is characterized by specific histone modifications, a centromere-specific histone H3 variant (CENP-A), and the enrichment of cohesin, condensin, and topoisomerase II.
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.
GeneRIF
Zhang et al., Hangzhou, China. In Lung Cancer, 2012
Our results demonstrate that elevated CENP-A expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
Impact
GeneRIF
Dalal et al., Bethesda, United States. In Cell, 2012
Whereas canonical H3 nucleosomes have octameric dimensions throughout the cell cycle, CENP-A nucleosomes are predominantly tetramers in early G1 phase, alter to octamers at the end of G1 through S phase, and revert to tetramers after replication.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
GeneRIF
Chung et al., Tokyo, Japan. In J Biol Chem, 2012
upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis.
[Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma].
GeneRIF
Liu et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Gli1 is up-regulated in hepatocellular carcinoma tissues
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer.
GeneRIF
Luo et al., Jinan, China. In Int J Med Sci, 2011
In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.
Nanoanalysis of the arthropod neuro-toxins.
Review
Nakajima, Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
Venom profiles are screened by MALDI-TOF fingerprinting analysis prior to purification of venomous components, then marked target toxins of small molecular mass (1000-5000) are characterized directly by means of mass spectrometric techniques such as Frit-FAB MS/MS, CID/PSD-TOF MS, Capil.-HPLC/Q-TOF
More papers using Gli antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Supplier
Zachos George et al., In The Journal of Cell Biology, 2000
... (ab3792) was purchased from Millipore, polyclonal phospho–CENP-A (Ser7) antibody was purchased from Cell Signaling Technology, and polyclonal antibody ...
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Supplier
Ruiz i Altaba Ariel et al., In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Supplier
McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
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