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GLI family zinc finger 1

Gli, CID, Gli1, CENP-A
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, Shh, Smo, V1a
Papers using Gli antibodies
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
Supplier
Xie Jingwu, In PLoS ONE, 2010
... Antibodies against GAPDH and Gli were purchased from Cell Signaling Technology, Inc ...
Basic mechanism of eukaryotic chromosome segregation
Supplier
Nigg Erich A. et al., In Chromosoma, 2004
... ab8898), H3 di-methyl K4 (2mH3K4, ab7766), H3 acetyl K18 (ab1191), as well as mouse monoclonal anti-CENP-A (ab13939) were obtained from Abcam (Cambridge, UK) ...
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
Supplier
Massfelder Thierry et al., In Molecular Cancer, 2003
... μM) or transiently transfected for 1 to 5 days with cDNA overexpression plasmids (pCMV6-XL5 vector, pCMV6-XL5-Smo and pCMV6-XL5-Gli1) according to the manufacturer's instructions (Clinisciences, Origene local distributor, Montrouge, France), ...
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
Supplier
Vale Ronald D. et al., In The Journal of Cell Biology, 2003
... Giet, University of Rennes, Rennes, France), rat anti–α-tubulin (1:150; Serotec), mouse anti–CENP-A (1:2,000; Abcam), rabbit anti-DIC (1:500; provided ...
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
Supplier
Karnitz Larry M. et al., In The Journal of Cell Biology, 2001
... Gli1 coding sequence was amplified by PCR and cloned into pEGFP-C3 (Clontech Laboratories, Inc.) to create ...
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Papers on Gli
Chemical shift assignments of a new folded domain from yeast Pcf11.
New
Mackereth et al., Pessac, France. In Biomol Nmr Assign, 02 Aug 2015
Pcf11 interacts with RNA and the C-terminal domain (CTD) of the largest subunit of RNA polymerase II via the CTD-interaction domain (CID), and other peptide regions mediate contacts with CF IA subunits Clp1 and Rna14/Rna15.
Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.
New
Impact
Earnshaw, Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, 31 Jul 2015
Inner kinetochore proteins associate with specialized centromeric chromatin containing the histone H3 variant centromere protein A (CENP-A) in place of H3.
SMO gene amplification and activation of the hedgehog pathway as novel mechanisms of resistance to anti-epidermal growth factor receptor drugs in human lung cancer.
New
Morgillo et al., Napoli, Italy. In Clin Cancer Res, 29 Jul 2015
EXPERIMENTAL DESIGN: Since Hedgehog (Hh) pathway has emerged as an important mediator of epithelial-to-mesenchymal transition (EMT), we studied the activation of Hh signaling in models of EGFR TKIs intrinsic or acquired resistance from both EGFR mutated and wild-type (WT) non small cell lung cancer (NSCLC) cell lines.
Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS.
New
Huhn et al., Jülich, Germany. In Anal Bioanal Chem, 28 Jul 2015
Tandem-MS analysis with collision induced dissociation (CID) using a CE-quadrupole-time-of-flight (QTOF) setup predominantly resulted in sulfate losses and did not yield any further characteristic fragment ions at high collision energies.
β-Lactoglobulin detected in human milk forms noncovalent complexes with maltooligosaccharides as revealed by chip-nanoelectrospray high-resolution tandem mass spectrometry.
New
Zamfir et al., Timişoara / Temesvár, Romania. In Amino Acids, 27 Jul 2015
In both cases, the MS analysis revealed the formation of BLG-Glc6 complex, which was characterized by top-down fragmentation in tandem MS (MS/MS) using collision-induced dissociation (CID).
The role of hedgehog signalling in skeletal health and disease.
Review
New
Alman, Durham, United States. In Nat Rev Rheumatol, 16 Jul 2015
UNASSIGNED: Hedgehog ligands bind to protein patched homologue 1 (PTC), a conserved receptor that activates the GLI family of transcription factors, which are involved in development, disease and skeletal repair processes.
Digging a hole under hedgehog: Downstream inhibition as an emerging anticancer strategy.
Review
New
Canettieri et al., Roma, Italy. In Biochim Biophys Acta, 12 Jul 2015
UNASSIGNED: Hedgehog signaling is a key regulator of development and stem cell fate and its aberrant activation is a leading cause of a number of tumors.
Targeting GLI factors to inhibit the Hedgehog pathway.
Review
New
Di Marcotullio et al., Roma, Italy. In Trends Pharmacol Sci, 10 Jul 2015
Recently, particular interest has been elicited by the identification of molecules able to hit glioma-associated oncogene (GLI) factors, the final effectors of the Hh pathway, which provide a valid tool to overcome anti-SMO resistance.
Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.
Review
New
Haustermans et al., Leuven, Belgium. In Oncotarget, 10 Jul 2015
Unfortunately, resistance against currently used SMO inhibitors has already been observed in basal cell carcinoma (BCC) patients.
Inactivation of a Gαs-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.
New
Impact
Gutkind et al., Bethesda, United States. In Nat Cell Biol, 30 Jun 2015
Mechanistically, we found that Gαs-PKA disruption promotes the cell autonomous Sonic Hedgehog pathway stimulation and Hippo signalling inhibition, resulting in the non-canonical activation of GLI and YAP1.
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
New
Impact
Black et al., Philadelphia, United States. In Science, 08 Jun 2015
A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location.
Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis.
New
Peng et al., Hefei, China. In Oncol Lett, May 2015
The expression of Gli-1, a key component of the Hh signaling pathway, and Snail, E-cadherin and N-cadherin, key components of EMT, was detected by reverse transcription polymerase chain reaction (RT-PCR) and western blotting.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms.
Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.
Review
New
Ekwall et al., Edinburgh, United Kingdom. In Cold Spring Harb Perspect Biol, Dec 2014
This is a phenomenon in which a transgene inserted within heterochromatin is variably expressed, but can be stably inherited in subsequent cell generations.
Centromeric heterochromatin: the primordial segregation machine.
Impact
Bloom, Chapel Hill, United States. In Annu Rev Genet, 2013
Centromeric heterochromatin is characterized by specific histone modifications, a centromere-specific histone H3 variant (CENP-A), and the enrichment of cohesin, condensin, and topoisomerase II.
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.
GeneRIF
Zhang et al., Hangzhou, China. In Lung Cancer, 2012
Our results demonstrate that elevated CENP-A expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
Impact
GeneRIF
Dalal et al., Bethesda, United States. In Cell, 2012
Whereas canonical H3 nucleosomes have octameric dimensions throughout the cell cycle, CENP-A nucleosomes are predominantly tetramers in early G1 phase, alter to octamers at the end of G1 through S phase, and revert to tetramers after replication.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
GeneRIF
Chung et al., Tokyo, Japan. In J Biol Chem, 2012
upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis.
[Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma].
GeneRIF
Liu et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Gli1 is up-regulated in hepatocellular carcinoma tissues
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer.
GeneRIF
Luo et al., Jinan, China. In Int J Med Sci, 2011
In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.
More papers using Gli antibodies
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Supplier
Zachos George et al., In The Journal of Cell Biology, 2000
... (ab3792) was purchased from Millipore, polyclonal phospho–CENP-A (Ser7) antibody was purchased from Cell Signaling Technology, and polyclonal antibody ...
GLI activates transcription through a herpes simplex viral protein 16-like activation domain
Supplier
Ruiz i Altaba Ariel et al., In The EMBO Journal, 1997
... GLI1 transgenic (GFP<-tetO->GLI1) mice were crossed ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Supplier
McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Janke, Macromolecular Biochemistry Research Center, Montpellier, France), and mouse anti–CENP-A (1:1,000; Abcam).
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