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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium inwardly-rectifying channel, subfamily J, member 9

GIRK3, Kir3.3, KCNJ9
G-protein activated potassium channel [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GIRK2, GIRK1, CAN, KIR, Kir4.1
Papers on GIRK3
GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.
New
Contet et al., New York City, United States. In Proc Natl Acad Sci U S A, Jul 2015
Constitutive deletion of the GIRK3 subunit has minimal phenotypic consequences, except in response to drugs of abuse.
GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.
New
Wickman et al., Minneapolis, United States. In J Neurosci, Jun 2015
Collectively, these data support the contention that the unique GIRK channel subtype in VTA DA neurons, the GIRK2/GIRK3 heteromer, regulates the sensitivity of the mouse mesolimbic DA system to drugs with addictive potential.
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.
Slesinger et al., Los Angeles, United States. In Neuron, 2014
Sorting nexin 27 (SNX27) is a PDZ-containing protein known to bind GIRK2c/GIRK3 channels, but its function in vivo is poorly understood.
Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity.
Tan et al., Genève, Switzerland. In J Neurosci, 2014
The plasticity of GIRK currents required NMDA receptor and CaMKII activation, and involved protein trafficking through specific PDZ domains of GIRK2c and GIRK3 subunit isoforms.
[Genetic polymorphisms commonly influencing efficacy of diverse addictive substances].
Review
Ikeda et al., In Nihon Arukoru Yakubutsu Igakkai Zasshi, 2014
The authors have focused on G-protein-activated inwardly rectifying potassium (GIRK) channel subunits, GIRK2 and GIRK3, that are important molecules in opioid transmission, and found that the single-nucleotide polymorphisms (SNPs) within the GIRK2 and GIRK3 gene regions were significantly associated with postoperative requirements of analgesics including opioids in patients who underwent abdominal surgery and mRNA expression of these genes in postmortem specimens, one of which was also associated with vulnerability to methamphetamine (METH) dependence.
[Genetic polymorphisms commonly associated with sensitivity to various addictive substances].
Review
Ikeda et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, 2013
The authors have focused on G-protein-activated inwardly rectifying potassium (GIRK) channel subunits, GIRK2 and GIRK3, which are important molecules in opioid transmission, and found that the SNPs within the GIRK2 and GIRK3 gene region were significantly associated with postoperative analgesic requirements, one of which was also associated with vulnerability to methamphetamine (METH) dependence.
A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny.
Hébert et al., Montréal, Canada. In J Recept Signal Transduct Res, 2013
Of note, we show that Kir3.1, in the absence of trafficking partner subunits, can exit the endoplasmic reticulum (ER) and reach the Golgi (though not the plasma membrane), and that expression of Kir3.3 subunits drastically reduced levels of Kir3.1 in the cell.
Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.
Slesinger et al., Los Angeles, United States. In Plos One, 2012
Deleting the RA domain in SNX27b (SNX27b-ΔRA) prevents the down-regulation of GIRK2c/GIRK3 channels.
Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel
Review
Weaver et al., Bethesda, United States. In Unknown Journal, 2012
ML297 shows a preference for the GIRK1/GIRK2 subunit combination compared to GIRK1/GIRK4 and is inactive on GIRK2/GIRK3 and a number of other potassium channels.
Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models.
Kozell et al., Portland, United States. In Alcohol Res, 2011
Subsequent work led to the identification of underlying quantitative trait genes (QTGs) (e.g., Mpdz) and high-quality QTG candidates (e.g., Kcnj9 and genes involved in mitochondrial respiration and oxidative stress) and their plausible mechanisms of action.
Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.
Luján et al., Albacete, Spain. In Eur J Neurosci, 2011
We investigated the temporal and spatial expression of GIRK1, GIRK2 and GIRK3 subunits in the developing and adult brain of mice and rats using biochemical, immunohistochemical and immunoelectron microscopic techniques.
Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.
GeneRIF
Han et al., Xi'an, China. In Mol Med Report, 2011
This study is the first to identify the expression of GIRK2-4 subunits in human esophageal smooth muscle cells.
Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits.
Luján et al., Barcelona, Spain. In Eur J Neurosci, 2010
Here, we used bioluminescence resonance energy transfer, co-immunoprecipitation, confocal and electron microscopy techniques to investigate the oligomerization of GABA(B) receptors with GIRK channels containing the GIRK3 subunit, whose contribution to functional channels is still unresolved.
Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3.
GeneRIF
Schachner et al., Hamburg, Germany. In J Biol Chem, 2010
a decisive role for the neuronal K(+) channel in regulating NCAM-dependent neurite outgrowth and attribute a physiologically meaningful role to the functional interplay of Kir3.3, NCAM, and TrkB in ontogeny
Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?
GeneRIF
Kara et al., Memphis, United States. In Psychiatry Res, 2010
The frequencies of GRIK3 (T928G) genotype distributions in the patients with schizophrenia were similar to those of their relatives.
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy.
Ottersen et al., Oslo, Norway. In Epilepsy Res, 2010
RESULTS: We found eight single SNPs, seven in KCNJ10 and one between KCNJ10 and KCNJ9, associated with TLE-FS (nominal p-values from 0.009 to 0.041).
Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.
GeneRIF
Buck et al., Portland, United States. In J Neurosci, 2009
Kcnj9 as a particularly promising candidate and report the development of a Kcnj9-null mutant model that exhibits significantly less severe withdrawal from pentobarbital as well as other sedative-hypnotics.
Expression of Kir3.3 potassium channel subunits in supraependymal axons.
GeneRIF
Veh et al., Berlin, Germany. In Neurosci Lett, 2008
The Kir3.3 subunit protein is expressed in raphe-derived axons at the light and electron microscopic level.
Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.
Review
Lüscher et al., Genève, Switzerland. In Trends Pharmacol Sci, 2008
Functional and behavioral studies now reveal that levels of RGS2 protein, through selective association with GIRK3, critically determine whether GABA(B) agonists are excitatory or inhibitory in the VTA.
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