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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium inwardly-rectifying channel, subfamily J, member 6

GIRK2, Weaver, BIR1, Kir3.2
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, GIRK1, HAD, ACID, OUT
Papers on GIRK2
Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity.
New
Robatzek et al., Norwich, United Kingdom. In New Phytol, Feb 2016
Constitutive interaction with the SUPPRESSOR OF BIR1 (SOBIR1) RLK contributes to RLP stability and kinase activity.
EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis.
New
Seeger et al., Berlin, Germany. In Am J Med Genet A, Feb 2016
UNASSIGNED: Weaver syndrome is an overgrowth syndrome characterized by pre- and postnatal overgrowth with distinctive craniofacial appearance.
Linking Essential Tremor to the Cerebellum-Animal Model Evidence.
Review
New
Handforth, Los Angeles, United States. In Cerebellum, Jan 2016
We describe models in which chronic partial PC loss is associated with tremor, such as the Weaver mouse, and others with PC loss that do not show tremor, such as the Purkinje cell degeneration mouse.
Frontispiece: Shaped Ceria Nanocrystals Catalyze Efficient and Selective Para-Hydrogen-Enhanced Polarization.
New
Bowers et al., Gainesville, United States. In Angew Chem Int Ed Engl, Dec 2015
Hagelin-Weaver et al.
Emerging potassium channel targets for the treatment of pain.
Review
New
Tsantoulas, London, United Kingdom. In Curr Opin Support Palliat Care, Jun 2015
Genetic analyses illustrate that K+ channel gene variation can predict pain sensitivity (KCNS1, GIRKs), risk for persistent pain (KCNS1, GIRKs, TRESK) and analgesic effectiveness (GIRK2).
Therapeutics and vaccines against chikungunya virus.
Review
New
Liljeström et al., Helsinki, Finland. In Vector Borne Zoonotic Dis, Apr 2015
Because of a sharp increase in new data in these fields, the present paper is complementary to previous reviews by Weaver et al. in 2012 and Kaur and Chu in 2013 .
Gigantism
Review
New
Eugster, Madagascar. In Unknown Journal, Mar 2015
Some of the most notorious overgrowth syndromes are Sotos syndrome, Beckwith-Wiedemann syndrome, Simpson-Golabi-Behmel syndrome and Weaver syndrome.
Antagonistic Interactions between the African Weaver Ant Oecophylla longinoda and the Parasitoid Anagyrus pseudococci Potentially Limits Suppression of the Invasive Mealybug Rastrococcus iceryoides.
Mohamed et al., Nairobi, Kenya. In Insects, 2014
The ant Oecophylla longinoda Latreille forms a trophobiotic relationship with the invasive mealybug Rastrococus iceryoides Green and promotes the latter's infestations to unacceptable levels in the presence of their natural enemies.
A new species of Stenopsyche, with descriptions of larvae and females of some species associated by gene sequences (Insecta: Trichoptera).
Wang et al., Nanjing, China. In Zootaxa, 2014
DNA from identifiable males of Stenopsyche lotus Weaver 1987 was also sequenced, but the larva and female of this species remain unknown.
From mice to men: lessons from mutant ataxic mice.
Review
Cendelin, Plzeň, Czech Republic. In Cerebellum Ataxias, 2013
Lurcher, Hot-foot, Purkinje cell degeneration, Nervous, Staggerer, Weaver, Reeler, and Scrambler mouse models and mouse models of SCA1, SCA2, SCA3, SCA6, SCA7, SCA23, DRPLA, Niemann-Pick disease and Friedreich ataxia are reviewed with special regard to cerebellar pathology, pathogenesis, functional changes and possible therapeutic influences, if any.
X-ray structure of the mammalian GIRK2-βγ G-protein complex.
Impact
MacKinnon et al., New York City, United States. In Nature, 2013
Here we present the 3.5 Å resolution crystal structure of the mammalian GIRK2 channel in complex with βγ G-protein subunits, the central signalling complex that links G-protein-coupled receptor stimulation to K(+) channel activity.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
GeneRIF
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that kcnj6 gene expression in mouse dorsal raphe nucleus
Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
GeneRIF
Galdzicki et al., Bethesda, United States. In Exp Neurol, 2012
GIRK overexpression in Ts65Dn mice has functional consequences affecting balance between GABA(A) and GABA(B) inhibition of CA1 pyramidal neurons in a pathway specific manner, that may contribute to cognitive deficits in Ts65 mouse model of Down syndrome.
Sperm GIRK2-containing K+ inward rectifying channels participate in sperm capacitation and fertilization.
GeneRIF
Thomas et al., Columbia, United States. In Syst Biol Reprod Med, 2011
studies in two different mammalian species point to a conserved mechanism by which the GIRK2 inward-rectifying K(+) ion channels support sperm function during fertilization
Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.
GeneRIF
Luján et al., Albacete, Spain. In Eur J Neurosci, 2011
Data describe the developmental regulation and subcellular diversity of neuronal GIRK/Kir3 channels, and support the contention that distinct subpopulations of GIRK channels exert separable influences on neuronal excitability.
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.
Impact
MacKinnon et al., New York City, United States. In Cell, 2011
G protein-gated K(+) channels (Kir3.1-Kir3.4)
Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.
GeneRIF
Dascal et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2011
The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated.
A stiff blow from the stroma: collagen crosslinking drives tumor progression.
Impact
Brugge et al., Boston, United States. In Cancer Cell, 2010
In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.
Erratum.
Impact
In Science, 1990
In the report "The response of living cells to very weak electric fields: The thermal noise limit" by J. C. Weaver and R. D. Astumian (26 Jan., p. 459), figures 2 and 3 on page 461 were inadvertently interchanged.
Report from the retiring chairman.
Impact
Rieser, In Science, 1975
This was started by a series of meetings under the heading of Arden House II, following the tradition of the meeting held in 1951 under the leadership of Warren Weaver.
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