Atrial selectivity of antiarrhythmic drugs.
Dresden, Germany. In J Physiol, 2013
Currently recognized atrial selective targets include atrial Nav1.5 channels, Kv1.5 channels and constitutively active Kir3.1/3.4 channels, each of which confers atrial selectivity by different mechanisms.
RGS8 accelerates G-protein-mediated modulation of K+ currents.
Tokyo, Japan. In Nature, 1998
When co-expressed in Xenopus oocytes with a G-protein-coupled receptor and a G-protein-coupled inwardly rectifying K+ channel (GIRK1/2), RGS8 accelerated not only the turning off but also the turning on of the GIRK1/2 current upon receptor stimulation, without affecting the dose-response relationship.