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GTPase, IMAP family member 4

Gimap4, IAN1
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, LYP, CD8, STAT4, IMAP
Papers on Gimap4
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
New
Finnish Pediatric Diabetes Registry et al., Turku, Finland. In J Immunol, Jul 2015
GIMAP4 is believed to contribute to the Th cell subtype-driven immunological balance via its role in T cell survival.
Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.
New
Henttinen et al., Turku, Finland. In Immunol Cell Biol, Feb 2015
Among GIMAP family, GIMAP4 is the only member reported to have true GTPase activity, and its transcription is found to be differentially regulated during early human CD4(+) T helper (Th) lymphocyte differentiation.
Genetics of vasculitis.
Review
González-Gay et al., Johannesburg, South Africa. In Curr Opin Rheumatol, 2015
These associations include ERAP1, CCR1-CCR3, STAT4, KLRC4, GIMAP4, and TNFAIP3 in Behçet's disease; BLK and CD40 in Kawasaki disease; SERPINA1 and SEMA6A in antineutrophil cytoplasmic antibody associated vasculitides; IL12B and FCGR2A/ FCGR2A in Takayasu arteritis; and CECR1 in a newly defined vascular inflammatory syndrome associated with adenosine deaminase (ADA2) deficiency.
Extensive variation between tissues in allele specific expression in an outbred mammal.
Goddard et al., Australia. In Bmc Genomics, 2014
We identified several long runs of neighbouring genes that showed either paternal or maternal ASE, one example was five adjacent genes (GIMAP8, GIMAP7 copy1, GIMAP4, GIMAP7 copy 2 and GIMAP5) that showed almost exclusive paternal expression in brain caudal lobe.
S100A9: A Potential Biomarker for the Progression of Non-Alcoholic Fatty Liver Disease and the Diagnosis of Non-Alcoholic Steatohepatitis.
Mao et al., Shanghai, China. In Plos One, 2014
In contrast, srebf1, tbx21, and gimap4 only showed limited discriminating abilities in different groups.
Genetics of Behçet's disease: lessons learned from genomewide association studies.
Review
Gül, İstanbul, Turkey. In Curr Opin Rheumatol, 2014
Genomewide studies also established associations with IL10, IL23R, CCR1, STAT4, KLRC4, GIMAP2/GIMAP4, and UBAC2 genes in Behçet's disease patients of different ethnicities.
Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.
Butcher et al., Cambridge, United Kingdom. In Plos One, 2013
Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival.
Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
Lee et al., Seoul, South Korea. In Ann Rheum Dis, 2013
p=7.70×10(-6)) in GIMAP4; rs10266069 (OR=1.32,
A role for the atopy-associated gene PHF11 in T-cell activation and viability.
Jones et al., Sydney, Australia. In Immunol Cell Biol, 2010
Knock-down of PHF11 also decreased cell viability and was accompanied by reduced expression of GIMAP4 and 5 genes required for T-cell differentiation, viability and homeostasis.
Comparative gene expression profiling between human cultured myotubes and skeletal muscle tissue.
Gómez-Foix et al., Lausanne, Switzerland. In Bmc Genomics, 2009
Coordinated reduced expression of five members of the GIMAP gene family, which form a cluster on chromosome 7, was shown, and the GIMAP4-reduction was validated.
Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.
GeneRIF
Lahesmaa et al., Turku, Finland. In Mol Cell Proteomics, 2009
GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2.
Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Ralpha449F knock-in T cell progenitors.
Abraham et al., Vancouver, Canada. In Mol Cell Proteomics, 2007
An iTRAQ (isobaric tags for relative and absolute quantitation) proteomics analysis was performed comparing CD4(-)CD8(-) double negative T cell progenitors from mice overexpressing IL-7 (Tg IL-7) (lymphoma-prone) with Tg IL-7 mice with a mutated IL-7 receptor (Tg IL-7/IL-7Ralpha(449F)) (lymphoma-protected). Several proteins involved in survival, proliferation, and apoptosis were found to be differentially expressed between the two samples, and three proteins of particular interest, GIMAP4, BIT1, and FKBP51, were validated by immunoblot analysis.
A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1.
GeneRIF
Butcher et al., Cambridge, United Kingdom. In J Immunol, 2007
A severe deficiency of Gimap4 expression in the inbred Brown Norway (BN) rat links this trait to the Gimap gene cluster on rat chromosome 4, the probable cause being an AT dinucleotide insertion in the BN Gimap4 allele.
Transcriptional analysis of clonal deletion in vivo.
Hogquist et al., Minneapolis, United States. In J Immunol, 2007
These included three up-regulated genes, bim, nur77, and ian1, and one down-regulated gene, lip1.
Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer.
Nakamura et al., Tokyo, Japan. In Int J Oncol, 2006
Some of them are known to be transcription factors and/or gene expression regulators such as TAF5L, TFCP2L4, PHF20, LMO4, TCF20, RFX2, and DKFZp547I048 as well as those encoding nucleotide-binding proteins such as C9orf76, EHD3, and GIMAP4.
Gimap4 accelerates T-cell death.
GeneRIF
Jacobs et al., Amsterdam, Netherlands. In Blood, 2006
Gimap4 accelerates the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 activation and phosphatidylserine exposure. Apoptosis directly correlates with the phosphorylation status of Gimap4.
Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.
GeneRIF
Roméo et al., Paris, France. In Blood, 2002
molecular and genetic properties; expression in resting T- and B-cells and decreased expression during lymphocyte activation
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