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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Allograft inflammatory factor 1

Gi, G-1, Protein G, Iba1, allograft inflammatory factor-1, AIF-1
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, ACID, HAD, GPCR
Papers using Gi antibodies
Roles for gliotransmission in the nervous system
Supplier
Meldolesi Jacopo et al., In The Journal of Cell Biology, 2004
... anti-EEA1 mAb’s were purchased from BD; anti-TfR mAb was obtained from Invitrogen; anti-VAMP3 rabbit and anti-Iba1 goat pAb’s were obtained from Abcam; horseradish peroxidase–conjugated goat anti–mouse ...
Clades of Adeno-associated viruses are widely disseminated in human tissues
Supplier
Kaspar Brian K et al., In Molecular Therapy, 2003
... (1:500; Invitrogen), goat-anti-ChAT (1:100; Millipore, Billerica, MA), guinea-pig-anti-GFAP (1:1,000; Advanced Immunochemical, Long Beach, CA) and rabbit-anti-Iba1 (1:500; Dako, Carpentaria, CA) ...
G protein pathways.
Supplier
Bishop-Bailey David et al., In Blood, 2001
... Normal rabbit IgG and antibodies for RXRα, Gq, and Gi/o/t/z/gust were from Santa Cruz Biotechnology (San Diego, CA); PPARγ ...
Chronic myeloid leukemia
Supplier
Combs Colin K et al., In Journal of Neuroinflammation, 1998
... Anti-Iba1 antibody was from Wako Chemicals USA, Inc (Richmond, VA, ...
Papers on Gi
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
New
Logothetis et al., Richmond, United States. In Pflugers Arch, Feb 2016
UNASSIGNED: We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011-1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signaling of the partner receptor.
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
New
Zhu et al., Homburg, Germany. In Proc Natl Acad Sci U S A, Feb 2016
We show here that TRPC4 activation requires coincident stimulation of Gi/o subgroup of G proteins and PLCδ, with a preference for PLCδ1 over PLCδ3, but not necessarily the PLCβ pathway commonly thought to be involved in receptor-operated TRPC activation.
Cerebrovascular pathology during the progression of experimental Alzheimer's disease.
New
Marchi et al., Montpellier, France. In Neurobiol Dis, Feb 2016
Positioning of reactive IBA1 microglia and GFAP astrocytes at the vasculature was rendered using confocal microscopy.
New development in studies of formyl-peptide receptors: critical roles in host defense.
Review
New
Wang et al., Shanghai, China. In J Leukoc Biol, Jan 2016
UNASSIGNED: Formyl-peptide receptors are a family of 7 transmembrane domain, Gi-protein-coupled receptors that possess multiple functions in many pathophysiologic processes because of their expression in a variety of cell types and their capacity to interact with a variety of structurally diverse, chemotactic ligands.
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
New
González-Maeso et al., Richmond, United States. In Sci Signal, Dec 2015
Previous findings demonstrated that the Gq/11-coupled serotonin 5-HT2A receptor and the Gi/o-coupled metabotropic glutamate 2 (mGlu2) receptor-GPCRs that are involved in signaling alterations associated with psychosis-assemble into a heteromeric complex in the mammalian brain.
Research and development of bronchodilators for asthma and COPD with a focus on G protein/KCa channel linkage and β2-adrenergic intrinsic efficacy.
Review
New
Oguma et al., Japan. In Pharmacol Ther, Dec 2015
Large-conductance Ca(2+)-activated K(+) (KCa) channels are activated by β2-adrenergic receptor agonists, via Gs, and suppressed by muscarinic receptor antagonists via Gi.
Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells.
New
Han et al., South Korea. In J Toxicol Sci, Dec 2015
In addition, CSE treatment activated PLC, PKC, and MAPK pathway through the Gi protein-coupled receptor.
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.
New
Impact
Yu et al., Houston, United States. In Nature, Dec 2015
Furthermore, this adaptive PTEN loss in brain metastatic tumour cells leads to an increased secretion of the chemokine CCL2, which recruits IBA1-expressing myeloid cells that reciprocally enhance the outgrowth of brain metastatic tumour cells via enhanced proliferation and reduced apoptosis.
Contribution of pertussis toxin to the pathogenesis of pertussis disease.
Review
New
Carbonetti, Baltimore, United States. In Pathog Dis, Nov 2015
PT inhibits G protein-coupled receptor signaling through Gi proteins in mammalian cells, an activity that has led to its widespread use as a cell biology tool.
Anticancer effect of adenosine on gastric cancer via diverse signaling pathways.
Review
New
Nishizaki et al., Nishinomiya, Japan. In World J Gastroenterol, Nov 2015
Secondly, the A3 adenosine receptor, linked to Gi/Gq proteins, mediates apoptosis by activating the Gq protein effector, phospholipase Cγ, to produce inositol 1,4,5-trisphosphate and diacylglycerol, which activate protein kinase C. Consequently, the mechanisms underlying adenosine-induced apoptosis vary, depending upon gastric cancer cell types.
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis.
Review
New
Wagner et al., Pomona, United States. In J Steroid Biochem Mol Biol, Aug 2015
Thus, estradiol and other hormones like leptin reduce energy intake at least partly by activating PI3K to disrupt the pleiotropic functions of Gi/o-coupled receptors that inhibit anorexigenic POMC neurons.
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
New
Impact
Offermanns et al., Bad Nauheim, Germany. In Nat Med, Feb 2015
Here we demonstrate that the short-chain fatty acid receptors FFA2 (encoded by FFAR2) and FFA3 (encoded by FFAR3) are expressed in mouse and human pancreatic beta cells and mediate an inhibition of insulin secretion by coupling to Gi-type G proteins.
The serum concentration of allograft inflammatory factor-1 is correlated with metabolic parameters in healthy subjects.
GeneRIF
Nakamura et al., Kyoto, Japan. In Metabolism, 2012
The serum AIF-1 concentrations were positively correlated with levels of fasting plasma glucose, hemoglobin A1c, triglycerides, and uric acid, and with waist circumference and BMI, and were inversely correlated with HDL cholesterol levels.
Allograft inflammatory factor-1 gene polymorphisms in patients with rheumatoid arthritis.
GeneRIF
Gawronska-Szklarz et al., Szczecin, Poland. In Genet Test Mol Biomarkers, 2012
Our results suggest that the AIF1 rs2259571 CC genotype is associated with the active form of RA.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.
GeneRIF
Gomez et al., Malmö, Sweden. In Cardiovasc Res, 2012
Overexpression of AIF-1 stimulates migration and proliferation of human vascular smooth muscle cells, whereas IRT-1 exerts opposite effects.
The dynamic expression of allograft inflammatory factor-1 in hepatic tissues and splenic cells of BALB/c mice with Schistosoma japonicum infection.
GeneRIF
Niu et al., Wuhan, China. In Tissue Antigens, 2012
AIF-1 was overexpressed in the liver of BALB/c mice infected with S. japonicum, and the interaction between AIF-1 and TNF-alpha or other cytokines played an important role in the pathogenesis and progression of hepatic schistosomiasis.
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
Impact
Logothetis et al., New York City, United States. In Cell, 2011
Serotonergic and glutamatergic drugs bind the mGluR2/2AR heterocomplex, which then balances Gi- and Gq-dependent signaling.
cAMP detection methods in HTS: selecting the best from the rest.
Review
Impact
Williams, Ramsgate, United Kingdom. In Nat Rev Drug Discov, 2004
Consequently, choosing the most appropriate technology can be a daunting task, particularly for Gi- or Gs-coupled receptors.
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
Impact
Bourne et al., San Francisco, United States. In Cell, 2003
Frontness depends upon Gi-mediated production of 3'-phosphoinositol lipids (PI3Ps), the activated form of Rac, a small GTPase, and F-actin.
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