Defects of cholesterol biosynthesis
In Journal of Inherited Metabolic Disease, 2005
... the medium was replaced with fresh culture medium supplemented with either 20 μM geranylgeranyltransferase inhibitor (GGTI-298; Calbiochem, Merk Chemicals Ltd, Nottingham, UK) or different concentrations of simvastatin (a gift from Merck, Sharpe, and Dohme BV, ...
Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.
Durham, United States. In Curr Cancer Drug Targets, Jan 2016
This review will provide an overview of the CaaX prenyltransferases, the rationale for targeting GGTase-I in cancer in particular, and the current status of GGTase-I inhibitor (GGTI) development.
Targeting protein prenylation for cancer therapy.
Tampa, United States. In Nat Rev Cancer, 2011
This observation prompted the development of inhibitors of farnesyltransferase (FT) and geranylgeranyl-transferase 1 (GGT1) as potential anticancer drugs.