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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gamma-glutamyltransferase 7

GGT4, D20S101, GGT7, gamma-glutamyltranspeptidase-like 3, gamma-glutamyl transpeptidase 4, GGT3, GGTL3
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GGT1, ACID, STEP, HAD, V1a
Papers on GGT4
γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth.
Li et al., Stanford, United States. In Bmc Cancer, 2014
GGT7 is a novel GGT family member that is highly expressed in brain and was previously shown to have decreased expression in gliomas.
Exploring the Arabidopsis sulfur metabolome.
Grill et al., Freising, Germany. In Plant J, 2014
We used our method to characterize the γ-glutamyl transferase mutant ggt4-1, which is involved in the vacuolar breakdown of glutathione conjugates in detoxification reactions.
Clades of γ-glutamyltransferases (GGTs) in the ascomycota and heterologous expression of Colletotrichum graminicola CgGGT1, a member of the pezizomycotina-only GGT clade.
Epstein et al., Davis, United States. In J Microbiol, 2013
2) In contrast, a main clade (GGT3) differs in 11 of the 14 highly conserved amino acids that are found in GGTs in the other kingdoms.
Comparative genomics of duplicate γ-glutamyl transferase genes in teleosts: medaka (Oryzias latipes), stickleback (Gasterosteus aculeatus), green spotted pufferfish (Tetraodon nigroviridis), fugu (Takifugu rubripes), and zebrafish (Danio rerio).
Kullman et al., Raleigh, United States. In J Exp Zool B Mol Dev Evol, 2012
Duplicate (paralogous) GGT sequences for GGT1 (GGT1 a and b), GGTL1 (GGTL1 a and b), and GGTL3 (GGTL3 a and b) were identified for each species.
Cytosolic action of phytochelatin synthase.
Grill et al., Freising, Germany. In Plant Physiol, 2010
Analysis of a triple mutant deficient in both Arabidopsis PCS and vacuolar gamma-glutamyl transpeptidase GGT4 is consistent with earlier observations of an efficient sequestration of GS conjugates into the vacuole and the requirement of GGT4 for their turnover.
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.
Oliver et al., Ames, United States. In Plant Physiol, 2008
In the ggt1-1/ggt4-1/oxp1-1 triple mutant with no GGT activity in any organs except young siliques, the 5OP concentration in leaves was not different from that in oxp1-1, suggesting that GGTs are not major contributors to 5OP production in Arabidopsis.
The human gamma-glutamyltransferase gene family.
Sneddon et al., Los Angeles, United States. In Hum Genet, 2008
In collaboration with the HUGO Gene Nomenclature Committee (HGNC) we have designated possible active genes with nucleotide or amino acid sequence similarity to GGT1, as GGT5 (formerly GGL, GGTLA1/GGT-rel), GGT6 (formerly rat ggt6 homologue) and GGT7 (formerly GGTL3, GGT4).
Localization of members of the gamma-glutamyl transpeptidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis.
Leustek et al., New Brunswick, United States. In Plant Physiol, 2007
They are designated GGT1 (At4g39640), GGT2 (At4g39650), GGT3 (At1g69820), and GGT4 (At4g29210).
gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis.
Meyer et al., Heidelberg, Germany. In Febs Lett, 2007
study identifies gamma-glutamyl transpeptidase 4 (At4g29210, GGT4) as the first step of vacuolar degradation of glutathione conjugates [GGT4]
Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis.
Oliver et al., Ames, United States. In Plant J, 2007
This study identifies gamma-glutamyltransferase 3 as catalyzing the obligate initial step in glutathione conjugate metabolism, and suggests that it has an important role in protecting plants from some xenobiotic chemicals.
Assessment of copper status in epileptic patients treated with anticonvulsant drugs by measuring the specific oxidase activity of ceruloplasmin.
Tutor et al., Santiago de Compostela, Spain. In Epilepsy Res, 2003
In 11 patients with a beta-globulin migrating GGT isoform (GGT3), a sensitive marker of cholestasis, the levels of ceruloplasmin, oxidase activity and total GGT activity were significantly higher (P<0.05)
Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.
Gu et al., Shanghai, China. In Biochem Biophys Res Commun, 2002
GGTL3 protein interacts with CT120, a plasma membrane-associated protein possibly involved in lung carcinogenesis.
Testing for genetic associations with the PAX gene family in a spina bifida population.
Northrup et al., Houston, United States. In Am J Med Genet, 2002
Significant findings were obtained for the following markers: marker locus D20S101 flanking the PAX1 gene (P = 0.019), marker locus D1S228 within the PAX7 gene (P = 0.011), and marker locus D2S110 within the PAX8 gene (P = 0.013).
Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions.
Wjst et al., Baltimore, United States. In Genet Epidemiol, 2001
Furthermore, it estimates with 95% certainty that the map location of the susceptibility gene is flanked by markers D20S186 and D20S101, which are approximately 16.3 cM apart.
Mapping of chromosome 20 for loss of heterozygosity in childhood ALL reveals a 1,000-kb deletion in one patient.
Grandchamp et al., Paris, France. In Leukemia, 1999
To further characterize the region of deletion and to precisely establish its frequency, we searched for LOH in 103 children with ALL using polymorphic markers in the previously described region of interest, namely between D20S101 and D20S887.
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