Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia.
Guangzhou, China. In Plos One, 2013
For further improving the prognosis evaluation system, we investigated the transcripts levels of PDCD7, FIS1, FAM3A, CA6, APP, KLRF1, ATCAY, GGT5 and Ang2 in 97 AML patients and 30 non-malignant controls, and validated using the published microarray data from 225 cytogenetically normal AML (CN-AML) patients treated according to the German AMLCG-1999 protocol.
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Minneapolis, United States. In Cell Biochem Biophys, 2008
Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL domain that recruits G beta(5), an outlying member of the G protein beta subunit family, and (iii) a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP.
The role of Gβ5 in vision.
Richmond, United States. In Prog Mol Biol Transl Sci, 2008
Unlike conventional Gβsthat form dimers with Gγ, Gβ5 partners with R7RGS proteins, which contain the G-protein gamma-like (GGL) domain, to act as a GTPase accelerating protein (GAP) complex on certain Gα subunits.
Physiological actions of regulators of G-protein signaling (RGS) proteins.
Suita, Japan. In Life Sci, 2004
For the latter mechanism, additional regulatory modules, such as PDZ, PX, and G-protein gamma subunit-like (GGL) domains, identified in several RGS proteins may be responsible: (i) PDZ domain of RGS12 interacts with a G-protein-coupled chemokine receptor, CXCR2, and thus facilitates its GAP action on CXCR2-mediated G-protein signals.