gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Golgi-associated, gamma adaptin ear containing, ARF binding protein 3

GGA3
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: GGA1, GGA2, p16, beta-secretase, CAN
Papers using GGA3 antibodies
Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination
Supplier
Rotin Daniela et al., In The Journal of Cell Biology, 2000
... The anti-GGA3 antibody was obtained from Santa Cruz Biotechnology, Inc ...
Papers on GGA3
Variance Component Quantitative Trait Locus Analysis for Body Weight Traits in Purebred Korean Native Chicken.
New
Lee et al., Taejŏn, South Korea. In Asian-australas J Anim Sci, Jan 2016
Two significant QTLs for growth were identified on chicken chromosome 3 (GGA3) for growth 16 to18 weeks (logarithm of the odds [LOD] = 3.24, Nominal p value = 0.0001) and GGA4 for growth 6 to 8 weeks (LOD = 2.88, Nominal p value = 0.0003).
GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.
New
Lavoie et al., Sherbrooke, Canada. In Mol Biol Cell, Jan 2016
Here we demonstrate that Golgi-localized, γ adaptin-ear-containing ADP ribosylation factor-binding protein 3 (GGA3) interacts directly with the TrkA cytoplasmic tail through an internal DXXLL motif and mediates the functional recycling of TrkA to the plasma membrane.
Quantitative trait loci with sex-specific effects for internal organs weights and hematocrit value in a broiler-layer cross.
New
Coutinho et al., Botucatu, Brazil. In J Appl Genet, Nov 2015
Additionally, five genome-wide significant QTL with different effects across sexes were mapped to GGA 8, 19 and 26 for heart weight; GGA26 for heart % and GGA3 for hematocrit value.
Genome-Wide Linkage Analysis Identifies Loci for Physical Appearance Traits in Chickens.
New
Wen et al., China. In G3 (bethesda), Oct 2015
Mb on chicken (Gallus gallus; GG) chromosome 3 (i.e., GGA3).
The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
von Arnim et al., Ulm, Germany. In Plos One, 2014
Recently, GGA1 and GGA3 were shown to interact with BACE1, to be expressed in neurons, and to be decreased in AD brain, whereas little is known about GGA2.
Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers.
Munari et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
Two QTL were found for tibia weight on GGA2 and GGA4, and one for tibia width on GGA3.
Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.
Bed'Hom et al., Paris, France. In Genet Sel Evol, 2014
The highly significant SNPs were associated with body weight gain (three SNPs on GGA5, one SNP on GGA1 and one SNP on GGA3), plasma coloration measured as optical density at wavelengths in the range 465-510 nm (10 SNPs and all on GGA10) and the percentage of β2-globulin in blood plasma (15 SNPs on GGA1 and one SNP on GGA2).
A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.
Győrffy et al., Budapest, Hungary. In Genome Med, 2014
RESULTS: According to this approach, the top driver oncogenes having a mutation prevalence over 5 % included AKT1, TRANK1, TRAPPC10, RPGR, COL6A2, RAPGEF4, ATG2B, CNTRL, NAA38, OSBPL10, POTEF, SCLT1, SUN1, VWDE, MTUS2, and PIK3CA, and the top tumor suppressor genes included PHEX, TP53, GGA3, RGS22, PXDNL, ARFGEF1, BRCA2, CHD8, GCC2, and ARMC4.
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
GeneRIF
Tesco et al., Boston, United States. In J Neurosci, 2012
depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
Review
Evin et al., Melbourne, Australia. In J Neurochem, 2012
Ubiquitination of BACE1 C-terminal Lys501 signals GGA3 for exporting BACE1 to the lysosome for degradation.
Met receptor: a moving target.
Review
Clague, Liverpool, United Kingdom. In Sci Signal, 2011
This requires the recruitment of the adaptor protein GGA3, mediated through the interaction of GGA3 with the activated form of the small guanosine triphosphatase Arf6 and indirect binding to phosphorylated Met receptor through the adaptor protein Crk.
Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein.
GeneRIF
Evin et al., Melbourne, Australia. In Neurobiol Dis, 2011
Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP.
Ubiquitin regulates GGA3-mediated degradation of BACE1.
GeneRIF
Tesco et al., Boston, United States. In J Biol Chem, 2010
GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
GeneRIF
Hiltunen et al., Kuopio, Finland. In J Biol Chem, 2010
seladin-1 downregulation increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis
Defects in cellular sorting and retroviral assembly induced by GGA overexpression.
GeneRIF
Freed et al., Frederick, United States. In Bmc Cell Biol, 2008
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
Caspase activation in Alzheimer's disease: early to rise and late to bed.
Review
Head et al., Boise, United States. In Rev Neurosci, 2007
During this time, caspase cleavage of the amyloid precursor protein (APP), the adaptor protein GGA3 involved with beta-amyloid production, and tau may promote the formation of beta-amyloid (A beta) and neurofibrillary tangles (NFTs).
Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease.
Review
Vassar, Chicago, United States. In Neuron, 2007
In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Abeta generation.
Interactions of GGA3 with the ubiquitin sorting machinery.
Impact
GeneRIF
Bonifacino et al., Bethesda, United States. In Nat Cell Biol, 2004
RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor and internalized epidermal growth factor (EGF) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF.
Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.
Impact
Kornfeld et al., Saint Louis, United States. In Science, 2002
Further, AP-1 contained bound casein kinase-2 that phosphorylated GGA1 and GGA3, thereby causing autoinhibition.
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.
Impact
GeneRIF
Hurley et al., Bethesda, United States. In Nature, 2002
structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors
share on facebooktweetadd +1mail to friends