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Golgi-associated, gamma adaptin ear containing, ARF binding protein 2

GGA2, Gga2p, Vear
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GGA1, GGA3, p16, AP-1, AGE
Papers on GGA2
An Analog-Sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway.
Martín et al., Madrid, Spain. In J Biol Chem, Feb 2016
We also demonstrated that, in the absence of SLT2, the GGA1 paralog GGA2 is essential for cells to survive under cell wall stress and for proper protein sorting through the carboxypeptidase Y (CPY) pathway.
Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes.
Lehtonen et al., Helsinki, Finland. In J Cell Sci, Jan 2016
We further found that CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process.
Quantitative trait loci with sex-specific effects for internal organs weights and hematocrit value in a broiler-layer cross.
Coutinho et al., Botucatu, Brazil. In J Appl Genet, Nov 2015
Thus, genome-wide significant QTL with similar effects across sexes were mapped to GGA2, 4 and 14 for heart weight, and to GGA2, 8 and 12 for gizzard %.
Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers.
Munari et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
Two QTL were found for tibia weight on GGA2 and GGA4, and one for tibia width on GGA3.
Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.
Bed'Hom et al., Paris, France. In Genet Sel Evol, 2014
The highly significant SNPs were associated with body weight gain (three SNPs on GGA5, one SNP on GGA1 and one SNP on GGA3), plasma coloration measured as optical density at wavelengths in the range 465-510 nm (10 SNPs and all on GGA10) and the percentage of β2-globulin in blood plasma (15 SNPs on GGA1 and one SNP on GGA2).
Detection of QTL controlling feed efficiency and excretion in chickens fed a wheat-based diet.
Narcy et al., France. In Genet Sel Evol, 2014
Nine of these QTL were genome-wide significant (four for feed intake on GGA1, one for feed efficiency on GGA2, and four for anatomy on GGA1, 2, 3 and 4).
The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
von Arnim et al., Ulm, Germany. In Plos One, 2014
Recently, GGA1 and GGA3 were shown to interact with BACE1, to be expressed in neurons, and to be decreased in AD brain, whereas little is known about GGA2.
Genome-wide linkage analysis and association study identifies loci for polydactyly in chickens.
Wen et al., China. In G3 (bethesda), 2014
One QTL located at 35 cM on the GGA2 was significant at the 1% genome-wise level and another QTL at the 1% chromosome-wide significance level was detected at 39 cM on GGA19.
Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.
Kornfeld et al., Saint Louis, United States. In G3 (bethesda), 2014
Using insertional mutagenesis, we found that Gga1 or Gga3 homozygous knockout mice were for the most part normal, whereas mice homozygous for two different Gga2 gene-trap alleles exhibited either embryonic or neonatal lethality in the C57BL/6 background, depending on the source of the vector utilized (Byg vs. Tigm, respectively).
Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line.
Peixoto et al., Curitiba, Brazil. In Springerplus, 2013
The osteoprotegerin gene (OPG), located on GGA2, is an important regulator of bone metabolism and reabsorption, being suggestive as a possible functional candidate gene associated with bone integrity in chickens.
Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group.
van den Heuvel-Eibrink et al., Rotterdam, Netherlands. In Blood, 2013
Highly expressed genes included HOXA11, HOXA10, RET, PERP, and GGA2.
Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.
Payne et al., Los Angeles, United States. In Nat Cell Biol, 2012
Data show that Gga2p binds directly to the Gga2p binds directly to the trans-Golgi network (TGN) PtdIns(4)-kinase Pik1p and contributes to Pik1p recruitment.
Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development.
Kornfeld et al., Saint Louis, United States. In Plos One, 2011
GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3.
Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5 .
Teng et al., Hefei, China. In Biochemistry, 2010
Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5
Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.
Philpott et al., Bethesda, United States. In J Biol Chem, 2009
Ubiquitin binding by Gga2 was not required for the trans-Golgi network to endosome trafficking of Arn1, but it was required for sorting of Arn1 into the vacuole.
Defects in cellular sorting and retroviral assembly induced by GGA overexpression.
Freed et al., Frederick, United States. In Bmc Cell Biol, 2008
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners.
Klip et al., Toronto, Canada. In Endocrinology, 2005
Newly synthesized GLUT4 enters an insulin-responsive compartment aided by GGA2 (an Arf-binding protein).
Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.
Payne et al., Los Angeles, United States. In Nat Cell Biol, 2003
Both proteins associate with the clathrin adaptor Gga2p in vivo; Ent5p also interacts with the clathrin adaptor complex AP-1 and clathrin.
Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
Kornfeld et al., Saint Louis, United States. In Science, 2001
Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR).
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