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GDNF family receptor alpha 3

GFRalpha3, GFRA3
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GDNF, RET, GFRalpha1, GFRalpha2, Acetyl-CoA Carboxylase
Papers on GFRalpha3
Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors.
GeneRIF
Alvarez et al., Santiago de Compostela, Spain. In J Clin Endocrinol Metab, 2012
The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas.
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression.
Ghelardini et al., Florence, Italy. In Psychopharmacology (berl), 2011
METHODS: Male mice were treated with 100 mg kg(-1) ALCAR daily for 7 days; 0.6 μg/mouse ARTN was acutely injected intracerebroventricularly. Gene knockdown of ARTN and GDNF family receptor alpha (GFRalpha3) was obtained by oligonucleotide antisense strategy.
Ret signalling integrates a craniofacial muscle module during development.
Roehl et al., London, United Kingdom. In Development, 2011
Three genes in the Ret pathway (gfra3, artemin2 and ret) are required specifically for the development of muscles attaching to the opercular bone (gill cover), but not other adjacent muscles.
Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.
GeneRIF
Gebhart et al., Pittsburgh, United States. In Am J Physiol Gastrointest Liver Physiol, 2011
Suggest that enhanced GFRalpha3 signaling in visceral afferents may contribute to development of colorectal hypersensitivity.
Enhanced artemin/GFRα3 levels regulate mechanically insensitive, heat-sensitive C-fiber recruitment after axotomy and regeneration.
GeneRIF
Koerber et al., Pittsburgh, United States. In J Neurosci, 2011
GFRalpha3, the receptor for artemin, is increased following axotomy and regeneration in heat-sensitive C-fibers.
Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways.
Barthold et al., Wilmington, United States. In Biol Reprod, 2010
Several of the genes showing the largest inductions regulate neuronal development or activity, including Pnoc (34-fold), Nptx2 (9-fold), Nfasc (4-fold), Gfra3 (3-fold), Unc5d (3-fold), and Crlf1 (3-fold).
Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors.
Osborne et al., Sydney, Australia. In J Comp Neurol, 2010
Most small unmyelinated neurons in adult rat dorsal root ganglia (DRG) express one or more of the coreceptors targeted by glial cell line-derived neurotrophic factor (GDNF), neurturin, and artemin (GFRalpha1, GFRalpha2, and GFRalpha3, respectively).
Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.
GeneRIF
Wong et al., Belo Horizonte, Brazil. In J Psychiatr Res, 2010
This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.
Pilotti et al., Milano, Italy. In Clin Cancer Res, 2010
RET activation (which may activate MET) involves the tumoral vascular component by means of RET/MET cross-talk and VEGFA (vascular endothelial growth factor A)/GFRalpha3 (glial cell-derived neurotrophic factor family receptor alpha3)/artemin-mediated signaling as revealed by VEGF receptor 2/RET coimmunoprecipitation.
Artemin-stimulated progression of human non-small cell lung carcinoma is mediated by BCL2.
Lobie et al., Auckland, New Zealand. In Mol Cancer Ther, 2010
Oncomine data indicate that expression of components of the ARTN signaling pathway (ARTN, GFRA3, and RET) is increased in neoplastic compared with normal lung tissues; increased expression of ARTN in NSCLC also predicted metastasis to lymph nodes and a higher grade in certain NSCLC subtypes.
Distribution of artemin and GFRalpha3 labeled nerve fibers in the dura mater of rat: artemin and GFRalpha3 in the dura.
Gold et al., Pittsburgh, United States. In Headache, 2010
OBJECTIVE: We examined the distribution of artemin and its receptor, glial cell line-derived neurotrophic factor family receptor alpha3 (GFRalpha3), in the dura mater of rats.
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice.
GeneRIF
Hsueh et al., Stanford, United States. In Febs Lett, 2009
Data report an autocrine/paracrine role of the artemin-GFRA3 signaling system in regulating early embryonic development and apoptosis.
Behavioral and cellular level changes in the aging somatosensory system.
Albers et al., Pittsburgh, United States. In Ann N Y Acad Sci, 2009
The receptor for the growth factor artemin (Artn), GFRalpha3, and the ion channel TRPV1, which is expressed by 95-99% of GFRalpha3-positive primary sensory neurons, was also decreased.
Treatment of transected peripheral nerves with artemin improved motor neuron regeneration, but did not reduce nerve injury-induced pain behaviour.
Risling et al., Stockholm, Sweden. In Scand J Plast Reconstr Surg Hand Surg, 2008
As the artemin high-affinity receptor GFRalpha-3 is present in Schwann cells and not in motor neurons, the effect on motor neuron axon regeneration may result from an indirect effect through Schwann cells in the injured nerve.
Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.
Impact
Kioussis et al., London, United Kingdom. In Nature, 2007
Functional genetic analysis revealed that Gfra3-deficiency results in impairment of Peyer's patch development, suggesting that the signalling axis RET/GFRalpha3/ARTN is involved in this process.
Evolution of the GDNF family ligands and receptors.
Review
Hätinen et al., Helsinki, Finland. In Brain Behav Evol, 2005
The role of artemin and persephin that signal via GFRalpha3 and GFRalpha4, respectively, is unknown in non-mammals.
Guidance cues involved in the development of the peripheral autonomic nervous system.
Review
Anderson et al., Melbourne, Australia. In Auton Neurosci, 2004
The rostral migration of cells to form the superior cervical ganglion (SCG) and the extension of axons along blood vessels involves artemin signaling through Ret and GFRalpha3, and the entry of sympathetic axons into target tissues involves neurotrophins and GDNF.
GDNF - a stranger in the TGF-beta superfamily?
Review
Saarma, Helsinki, Finland. In Eur J Biochem, 2000
GFRalpha1, GFRalpha2, GFRalpha3 and GFRalpha4 are the physiological coreceptors for GDNF, neurturin, artemin and persephin, respectively.
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