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GDNF family receptor alpha 1

GFRalpha1, GFRA1, GDNFR-alpha
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: GDNF, RET, GFRalpha2, Acetyl-CoA Carboxylase, Alpha-1
Papers on GFRalpha1
Comparison of Diverse Differential Plating Methods to Enrich Bovine Spermatogonial Cells.
Visintin et al., São Paulo, Brazil. In Reprod Domest Anim, Feb 2016
Recovered cells were analysed for the expression of SSC molecular markers by quantitative RT-PCR (GFRA1, CXCR4, ITGA6, THY1) and flow cytometry (GFRA1, CXCR4 and ITGA6).
Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats.
Tharasanit et al., Bangkok, Thailand. In J Reprod Dev, Jan 2016
The colonies expressed mRNA for GFRA1, ZBTB16, RET and POU5F1.
A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis.
Jawaheer et al., Tochigi, Japan. In Arthritis Res Ther, Dec 2015
Potential candidate genes in these regions include MAP3K7, BACH2 (6q15), GFRA1 (10q25.3),
Transcription and imprinting dynamics in developing postnatal male germline stem cells.
Cairns et al., Salt Lake City, United States. In Genes Dev, Dec 2015
To better understand, we conducted extensive genomic profiling at multiple postnatal stages on subpopulations enriched for particular markers (THY1, KIT, OCT4, ID4, or GFRa1).
Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling.
Liu et al., Beijing, China. In Reproduction, Apr 2015
Other transcription factors and signaling pathways (GDNF-RET-GFRA1 signaling, FGF2-MAP2K1 signaling, CXCL12-CXCR4 signaling, CCL9-CCR1 signaling, FSH-nociceptin/OPRL1, retinoic acid/FSH-NRG/ERBB4, and AR/RB-ARID4A/ARID4B) are also addressed.
Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation.
He et al., Shanghai, China. In Sci Rep, 2014
RT-PCR, immunocytochemistry, and Western blots revealed that this cell line was positive for a number of human spermatogonial and SSC hallmarks, including VASA, DAZL, MAGEA4, GFRA1, RET, UCHL1, GPR125, PLZF and THY1, suggesting that these cells are human SSCs phenotypically.
Biology and identity of fish spermatogonial stem cell.
de França et al., Belo Horizonte, Brazil. In Gen Comp Endocrinol, 2014
However, some highly conserved vertebrate molecular markers, such as Gfra1 and Pou5f1/Oct4, are now available representing important candidates for studies evaluating the regulation of SSCs in fish and even functional investigations using germ cells transplantation.
Distribution of GFRA1-expressing spermatogonia in adult mouse testis.
Vicini et al., Roma, Italy. In Reproduction, 2012
GFRA1 expression is regulated by GDNF and in cultures of isolated seminiferous tubules, we found that GDNF expression and secretion by Sertoli cells is stage-dependent, being maximal in stages II-VI and decreasing thereafter.
Expression of glial cell line-derived neurotrophic factor and its receptors in cultured retinal Müller cells under high glucose circumstance.
Li et al., Shanghai, China. In Anat Rec (hoboken), 2012
Expression levels of GDNF and GFRalpha1 proteins increase gradually over time in experimental diabetic retinopathy under high glucose and exogenous GDNF-treated conditions.
Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra.
Burke et al., New York City, United States. In J Neurochem, 2011
Post-synaptic striatal glial cell line-derived neurotrophic factor receptor-alpha1 expression effects the biology of dopamine neurons in vivo.
A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration.
Too et al., Singapore, Singapore. In J Neurochem, 2010
these unanticipated results indicate that GFRalpha1b is involved in glioma migration through glial cell line-derived neurotrophic factor -GFRalpha1b-Neural Cell Adhesion Molecule signaling complex and modulation of RhoA expression
Beyond the cell surface: new mechanisms of receptor function.
Ibáñez, Stockholm, Sweden. In Biochem Biophys Res Commun, 2010
GFRalpha1 is a GPI-anchored receptor for GDNF (glial cell line-derived neurotrophic factor), a neuronal growth factor with widespread functions in the developing and adult nervous system.
Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line.
Kimmins et al., Québec, Canada. In Plos One, 2009
Histone methylation and acetylation regulate Pou5f1 and Gfra1 in male germ cell.
Glycosaminoglycan (GAG) biosynthesis and GAG-binding proteins.
Zhang, Saint Louis, United States. In Prog Mol Biol Transl Sci, 2009
GAGs regulate multiple signaling pathways including, but not limited to, fibroblast growth factor (FGF)/FGFR, hepatocyte growth factor (HGF)/c-Met, glial cell line-derived neurotrophic factor (GDNF)/c-Ret/GFRalpha1, vascular endothelial growth factor (VEGF)/VEGFR, platelet derived growth factor (PDGF)/PDGFR, BAFF/TACI, Indian hedgehog, Wnt, and BMP signaling pathways,where genetic studies have revealed an absolute requirement for GAGs in these pathways.
Functional role of the RET dependence receptor, GFRa co-receptors and ligands in the pituitary.
Alvarez et al., Santiago de Compostela, Spain. In Front Horm Res, 2009
In the adenopituitary RET and the co-receptor GFRa1 are expressed exclusively in the somatotrophs secreting GH.
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.
Ibáñez et al., Stockholm, Sweden. In Cell, 2003
Association of NCAM with GFRalpha1, a GPI-anchored receptor for GDNF, downregulates NCAM-mediated cell adhesion and promotes high-affinity binding of GDNF to p140(NCAM), resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET, a known GDNF signaling receptor.
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor.
Rosenthal et al., San Francisco, United States. In Nature, 1997
GDNF mediates its actions through a multicomponent receptor system composed of a ligand-binding glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-alpha) and the transmembrane protein tyrosine kinase Ret.
Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
Davies et al., Saint Andrews, United Kingdom. In Nature, 1997
GDNF signals through a receptor complex consisting of the receptor tyrosine kinase Ret and a glycosyl-phosphatidylinositol (GPI)-linked receptor termed GDNFR-alpha.
Characterization of a multicomponent receptor for GDNF.
Rosenthal et al., San Francisco, United States. In Nature, 1996
Here we show that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-alpha) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity.
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.
Fox et al., Thousand Oaks, United States. In Cell, 1996
We report the expression cloning and characterization of GDNFR-alpha, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF).
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