general transcription factor TFIIB
Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.
Stanford, United States. In Science, 2010
A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstrom resolution revealed the amino-terminal region of TFIIB, including a loop termed the "B finger," reaching into the active center of the polymerase where it may interact with both DNA and RNA, but this structure showed little of the carboxyl-terminal region.
Transcriptional activation. Tuning-up transcription.
United States. In Curr Biol, 1995
Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.