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GTF2B general transcription factor IIB

general transcription factor TFIIB
Top mentioned proteins: POLYMERASE, CAN, TBP, ACID, p105
Papers on general transcription factor TFIIB
A new paradigm for transcription factor TFIIB functionality.
Usheva et al., Boston, United States. In Sci Rep, 2013
However, the general transcription factor TFIIB is presumed to be universally required for RNAP2 transcription initiation.
NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon Methanosarcina mazei Gö1.
Schmitz et al., Kiel, Germany. In Febs J, 2010
Finally, strong interactions between NrpRII and the general transcription factors TATA-binding proteins (TBP) 1-3 and the general transcription factor TFIIB (TFB) were demonstrated, interactions which are also sensitive to 2-oxoglutarate.
New insights into the role of TFIIB in transcription initiation.
Roberts et al., Manchester, United Kingdom. In Transcription, 2010
The general transcription factor TFIIB plays essential, but as yet unclear, roles in transcription initiation by RNA polymerase II.
Phosphorylation of TFIIB links transcription initiation and termination.
Roberts et al., Manchester, United Kingdom. In Curr Biol, 2010
The general transcription factor TFIIB plays a central role in preinitiation complex (PIC) assembly and the recruitment of RNA polymerase II (RNA pol II) to the promoter.
Human negative elongation factor activates transcription and regulates alternative transcription initiation.
Li et al., San Antonio, United States. In J Biol Chem, 2010
This was accompanied by decreased histone modifications associated with active transcription initiation (H3K9Ac) and elongation (H3K36Me3), as well as reduced recruitment of the general transcription factor TFIIB and increased overall histone occupancy at a subset of the down-regulated promoters.
Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.
Impact
Kornberg et al., Stanford, United States. In Science, 2010
A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstrom resolution revealed the amino-terminal region of TFIIB, including a loop termed the "B finger," reaching into the active center of the polymerase where it may interact with both DNA and RNA, but this structure showed little of the carboxyl-terminal region.
Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells.
Meisterernst et al., Münster, Germany. In Genome Biol, 2009
BACKGROUND: The general transcription factor TFIIB and its antagonist negative cofactor 2 (NC2) are hallmarks of RNA polymerase II (RNAPII) transcription.
Gene looping is conferred by activator-dependent interaction of transcription initiation and termination machineries.
Ansari et al., Detroit, United States. In J Biol Chem, 2009
Instead, activators physically interacted with the general transcription factor TFIIB when the genes were activated and in a looped configuration.
TFIIB aptamers inhibit transcription by perturbing PIC formation at distinct stages.
Lis et al., Ithaca, United States. In Nucleic Acids Res, 2008
Here, we report the isolation and characterization of high-affinity RNA aptamers that bind to the yeast general transcription factor TFIIB.
TFIIB and the regulation of transcription by RNA polymerase II.
Review
Roberts et al., Manchester, United Kingdom. In Chromosoma, 2007
The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II.
Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC.
Impact
Hahn et al., Seattle, United States. In Cell, 2004
Biochemical probes positioned on the surface of the general transcription factor TFIIB were used to probe the architecture of the RNA polymerase II (Pol II) transcription preinitiation complex (PIC).
Transcription factor IIB acetylates itself to regulate transcription.
Impact
Usheva et al., Boston, United States. In Nature, 2003
Here we show that the general transcription factor TFIIB, which is required for the initiation of eukaryotic polymerase II transcription, is acetylated.
Crystal structure of a transcription factor IIIB core interface ternary complex.
Impact
Sigler et al., New Haven, United States. In Nature, 2003
The amino-terminal half of Brf1 shares a high degree of sequence similarity with the polymerase II general transcription factor TFIIB, but it is the carboxy-terminal half of Brf1 that contributes most of its binding affinity with TBP.
Transcriptional activation. Tuning-up transcription.
Review
Reinberg et al., United States. In Curr Biol, 1995
Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.
Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.
Impact
Green et al., Worcester, United States. In Nature, 1993
We have previously shown that an acidic activator can directly interact with the general transcription factor TFIIB and increase its stable assembly into a preinitiation complex.
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