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Ring finger protein 128

Gene related to anergy in lymphocytes, RNF128
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CD4, JNK, Interleukin-2, AGE
Papers on Gene related to anergy in lymphocytes
Rare mutations associating with serum creatinine and chronic kidney disease.
Stefansson et al., Reykjavík, Iceland. In Hum Mol Genet, 2015
In addition to replicating established loci, we discovered missense and loss-of-function variants associating with SCr in three solute carriers (SLC6A19, SLC25A45 and SLC47A1) and two E3 ubiquitin ligases (RNF186 and RNF128).
Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis.
Wang et al., United States. In J Immunol, 2014
Gene related to anergy in lymphocytes (GRAIL) is critical for the impairment of CD4 T cell proliferation.
GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness.
Review
Fathman et al., Stanford, United States. In Febs J, 2011
GRAIL (gene related to anergy in lymphocytes, also known as RNF128), an ubiquitin-protein ligase (E3), utilizes a unique single transmembrane protein with a split-function motif, and is an important gatekeeper of T-cell unresponsiveness.
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Impact
Dong et al., Houston, United States. In Immunity, 2010
Gene related to anergy in lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell tolerance.
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.
Seroogy et al., Madison, United States. In J Biol Chem, 2010
GRAIL (gene related to anergy in lymphocytes), is an E3 ubiquitin ligase with increased expression in anergic CD4+ T cells.
The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells.
GeneRIF
Fathman et al., Stanford, United States. In J Immunol, 2009
GRAIL can down-modulate the expression of CD83 antigen on CD4 T cells.
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
GeneRIF
Wu et al., Stanford, United States. In J Immunol, 2009
endogenous GRAIL regulates general cell cycle and proliferation of primary naive CD4 T cells.
Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver.
Kasuga et al., Kōbe, Japan. In J Mol Endocrinol, 2009
Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes.
Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures.
Seroogy et al., Madison, United States. In Clin Exp Immunol, 2009
Gene related to anergy in lymphocytes (GRAIL), an anergy-related E3 ubiquitin ligase, was up-regulated in the SEB-exposed CD25(+) and CD25(-)FoxP3(+)Vbeta8(+)CD4(+) T cells and FoxP3(-)CD25(-)Vbeta8(+)CD4(+) T cells, suggesting that GRAIL may be important for dominant and recessive tolerance.
Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation.
Seroogy et al., Madison, United States. In Acta Haematol, 2008
The E3 ubiquitin ligase, GRAIL (RNF128), is expressed in the bone marrow, but its role is as yet undefined.
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
GeneRIF
Fathman et al., Stanford, United States. In J Biol Chem, 2008
GRAIL captures and then ubiquitinates transmembrane proteins across the cell membrane
Upregulation of GRAIL is associated with remission of ulcerative colitis.
GeneRIF
Hayashi et al., Suita, Japan. In Am J Physiol Gastrointest Liver Physiol, 2008
GRAIL expression was significantly higher in patients with ulcerative colitis in remission than in patients with active disease and in healthy volunteers.
Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression.
GeneRIF
Anderson et al., Boston, United States. In J Immunol, 2007
Inhibition of T cell activation is not due to apoptosis or disruption of proximal T- cell receptor signaling, but is associated with up-regulation of GRAIL in CD4+ T cells, with modest effects on other E3 ubiquitin ligases.
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