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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gelsolin

gelsolin
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, fibrillin-1, HAD, ACID
Papers using gelsolin antibodies
Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase*
Supplier
Horiuchi Hisanori et al., In The Journal of Biological Chemistry, 2005
... The cDNAs encoding human cytosolic gelsolin (Gsn) fragments (G1–3, aa 1–357; G4–6, aa 358–730) were obtained by PCR using Marathon-Ready human bone marrow cDNA (Clontech) as a template ...
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Supplier
Moschetta Antonio, In PLoS ONE, 2001
... Antibodies used include mouse antibodies against human gelsolin (Abcam), β-actin (Sigma-Aldrich), GAPDH (Santa ...
Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated In vitro by the phosphorylation state of the polypeptide.
Supplier
Cotmore Susan, In PLoS Pathogens, 1997
... Antibodies against actin (MP Biomedicals: C-4, 691002), gelsolin (BD Biosciences # 610413), α-tubulin, and myc-tag ...
Papers on gelsolin
Proteomic analysis of the INS-1E secretome identify novel vitamin D-regulated proteins.
New
Thorsby et al., Oslo, Norway. In Diabetes Metab Res Rev, Feb 2016
Up-regulation of proteins implicated in β-cell growth and proliferation, such as IGF2, IGFBP7 and gelsolin, suggest that 1,25-(OH)2 D3 has a positive effect on β-cell growth and proliferation.
The Dendritic Cell MHC II Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.
New
Santambrogio et al., United States. In J Biol Chem, Feb 2016
Processing enzymes were identified by reference to a database of experimentally determined cleavage sites and experimentally validated for four epitopes derived from complement 3, collagen II thymosin β4 and gelsolin.
Fragmented gelsolins are increased in rheumatoid arthritis-associated interstitial lung disease with usual interstitial pneumonia pattern.
New
Inase et al., Tokyo, Japan. In Allergol Int, Jan 2016
RESULTS: In individual comparisons of BALF samples, the levels of the protein gelsolin and Ig kappa chain C region were significantly higher in the UIP pattern than in the OP pattern.
Comparative mass spectrometric and immunoassay-based proteome analysis in serum of Duchenne muscular dystrophy patients.
New
van der Burgt et al., Leiden, Netherlands. In Proteomics Clin Appl, Jan 2016
MS-based results were compared with ELISA for vitamin D binding protein (GC), fibulin-1 (FBLN1), gelsolin (GSN) and carbonic anhydrase 1 (CA1).
Cytoskeleton deregulation and impairment in amino acids and energy metabolism in early atherosclerosis at aortic tissue with reflection in plasma.
New
Alvarez-Llamas et al., Madrid, Spain. In Biochim Biophys Acta, Jan 2016
RESULTS: Data link the structural remodeling taking place in atherosclerotic arteries in terms of loss of contractile properties and favored cellular migration, with an up-regulation of integrin linked kinase, tropomyosin isoform 2 and capping protein gelsolin-like, and a down-regulation of vinculin.
Regulation of Sperm Capacitation and the Acrosome Reaction by PIP 2 and Actin Modulation.
Review
New
Finkelstein et al., Ramat Gan, Israel. In Asian J Androl, Jul 2015
The increase in F-actin during capacitation depends upon inactivation of the actin severing protein, gelsolin, by its binding to phosphatydilinositol-4, 5-bisphosphate (PIP 2 ) and its phosphorylation on tyrosine-438 by Src.
Plant villins: versatile actin regulatory proteins.
Review
Zhang et al., Beijing, China. In J Integr Plant Biol, 2015
Villin, a member of the villin/gelsolin/fragmin superfamily of proteins, is an important regulator of actin.
Potential therapeutic implications of gelsolin in Alzheimer's disease.
Review
Hua et al., Nanjing, China. In J Alzheimers Dis, 2014
Gelsolin, a multifunctional actin-binding protein, exists intracellularly as a cytoplasmic form and extracellularly as a secreted form in blood/cerebrospinal fluid.
Hereditary erythrocytosis, thrombocytosis and neutrophilia.
Review
Gotlib et al., Stanford, United States. In Best Pract Res Clin Haematol, 2014
More recently, germline mutations in JAK2, distinct from JAK2 V617F, and mutation of the gelsolin gene, were uncovered in several pedigrees of hereditary thrombocytosis.
The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science.
Review
Andersson et al., Lund, Sweden. In J Transl Med, 2013
Examples of candidate biomarkers that have been identified from these pancreas studies include among others, asporin, CD9, CXC chemokine ligand 7, fibronectin 1, galectin-1, gelsolin, intercellular adhesion molecule 1, insulin-like growth factor binding protein 2, metalloproteinase inhibitor 1, stromal cell derived factor 4, and transforming growth factor beta-induced protein.
Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells.
GeneRIF
Malicka-Błaszkiewicz et al., Wrocław, Poland. In Life Sci, 2012
alterations in the expression level of gelsolin and its subcellular distribution may be directly responsible for determining migration capacity of human cancer cells
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.
Impact
GeneRIF
Sadler et al., Australia. In Immunity, 2012
The antiviral protein kinase R (PKR) inhibited the key actin-modifying protein gelsolin to regulate actin dynamics.
Penetration resistance: PKR's other talent.
Impact
Stuart et al., Boston, United States. In Immunity, 2012
(2012) show that protein kinase R (PKR) regulates the cytoskeleton via an interaction with gelsolin.
Down-regulation of gelsolin may play a role in the progression of inverted papilloma through an antiapoptotic mechanism.
GeneRIF
Cho et al., Seoul, South Korea. In Am J Rhinol Allergy, 2012
lower expression in inverted papilloma
Long chain acyl CoA synthetase 1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis.
GeneRIF
Yun et al., Taegu, South Korea. In Biochem Biophys Res Commun, 2012
Gsn knockdown suppressed expression of lipogenic genes but strikingly increased that of Tnfalpha and Il6, which may have connections with lipolytic capacity of these genes.
Familial amyloid polyneuropathy.
Review
Impact
Said et al., Créteil, France. In Lancet Neurol, 2011
Less often the precursor of amyloidosis is mutant apolipoprotein A-1 or gelsolin.
Tropomyosin-based regulation of the actin cytoskeleton in time and space.
Review
Impact
Hardeman et al., Westmead, Australia. In Physiol Rev, 2008
The functional specificity of tropomyosins is related to the collaborative interactions of the isoforms with different actin binding proteins such as cofilin, gelsolin, Arp 2/3, myosin, caldesmon, and tropomodulin.
Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Impact
Scita et al., Milano, Italy. In Nat Cell Biol, 2004
One family of capping proteins, whose prototype is gelsolin, shares modular architecture, mechanism of action, and regulation through signalling-dependent mechanisms, such as Ca(2+) or phosphatidylinositol-4,5-phosphate binding.
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