Anti-tumoral effects of miR-3189-3p in glioblastoma.
New Orleans, United States. In J Biol Chem, Apr 2015
In vitro, the functionality of miR-3189-3p was tested by RNA-binding protein immunoprecipitation, and miR-3189-3p coimmunoprecipitated with Argonaute 2 together with two of its major predicted gene targets, the SF3B2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.
Gαq signalling: the new and the old.
Madrid, Spain. In Cell Signal, 2014
Novel effectors include p63RhoGEF, that provides a link between G protein-coupled receptors and RhoA activation, phosphatidylinositol 3-kinase (PI3K), implicated in the regulation of the Akt pathway, or the cold-activated TRPM8 channel, which is directly inhibited upon Gαq binding.
Strike a pose: Gαq complexes at the membrane.
Ann Arbor, United States. In Trends Pharmacol Sci, 2014
Gαq functions at the intracellular surface of the plasma membrane, as do its best-characterized targets, phospholipase C-β, p63RhoGEF, and GPCR kinase 2 (GRK2).
p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.
Charlottesville, United States. In Trends Cardiovasc Med, 2012
This review focuses on the function and mechanisms of activation of p63RhoGEF (Arhgef 25; GEFT) recently identified in SM and its possible role in selective targeting of RhoA-mediated regulation of basal blood pressure through agonists that couple through G(αq/11).