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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Rho/Rac guanine nucleotide exchange factor

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: Rhodopsin, Actin, V1a, RhoA, Rac1
Papers on GEF
Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
Renslo et al., San Francisco, United States. In Chemmedchem, Feb 2016
Phosphorylation of eIF2α (eIF2α-P) results in attenuation of global protein synthesis via the inhibitory effects of eIF2α-P on eIF2B, the guanine exchange factor (GEF) for eIF2.
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution.
Lim et al., San Francisco, United States. In Elife, Feb 2016
Distortion by oncogenic Ras alleles was dependent on the balance of positive (GEF) and negative (GAP) regulators in the system.
The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
Fromme et al., Ithaca, United States. In Elife, Feb 2016
We report a crystal structure revealing that the N-terminal DCB and HUS regulatory domains of the Arf-GEF Sec7 form a single structural unit.
SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival By Modulation of the DNA Repair Response to Temozolomide.
Tran et al., Phoenix, United States. In Mol Cancer Res, Feb 2016
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
RASSF1A suppresses the invasion and metastatic potential of human non-small cell lung cancer cells by inhibiting YAP activation through the GEF-H1/RhoB pathway.
Zalcman et al., Caen, France. In Cancer Res, Feb 2016
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimulating its ability to activate the anti-metastatic small GTPase RhoB.
eIF2B: recent structural and functional insights into a key regulator of translation.
Proud et al., Adelaide, Australia. In Biochem Soc Trans, Jan 2016
The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur.
Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.
von Dassow et al., Madison, United States. In Nat Cell Biol, Nov 2015
The waves are modulated by cyclin-dependent kinase 1 (Cdk1) activity and require the Rho GEF (guanine nucleotide exchange factor), Ect2.
Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.
Katzav, Jerusalem, Israel. In Oncotarget, Nov 2015
One of these, Vav1, is normally expressed exclusively in the hematopoietic system, where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), strictly regulated by tyrosine phosphorylation.
Regulating G protein activity by lipase-independent functions of phospholipase C.
Litosch, Miami, United States. In Life Sci, Oct 2015
GEF and GAPs modulate the G protein GTPase cycle.
Circadian Rhythms in Rho1 Activity Regulate Neuronal Plasticity and Network Hierarchy.
Blau et al., East New York, United States. In Cell, Sep 2015
Rhythms in Rho1 activity are controlled by clock-regulated transcription of Puratrophin-1-like (Pura), a Rho1 GEF.
Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses.
Tolias et al., Houston, United States. In Neurosci Lett, Sep 2015
Though the number of both GEFs and GAPs greatly exceeds that of Rho-GTPases, loss of even a single GEF or GAP often has profound effects on cognition and behavior.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Ron et al., Nottingham, United Kingdom. In Science, Jun 2015
Clustered missense mutations were found at the amino-terminal portion of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.
Crossroads of PI3K and Rac pathways.
Hirsch et al., Torino, Italy. In Small Gtpases, 2014
For instance, phosphorylated lipids produced by PI3Ks recruit and activate GEF and GAP proteins, key modulators of Rac function.
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Lin et al., Xiamen, China. In Cell Metab, 2014
Concurrently, the guanine nucleotide exchange factor (GEF) activity of Ragulator toward RAG is inhibited by AXIN, causing dissociation from endosome and inactivation of mTORC1.
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.
Yamada et al., Bethesda, United States. In Nat Cell Biol, 2014
We first identified βPix, a guanine nucleotide exchange factor (GEF), as a specific regulator of migration in 3D collagen using an affinity-precipitation-based GEF screen.
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic.
Dermardirossian et al., Los Angeles, United States. In Dev Cell, 2012
present evidence that depletion of GEF-H1, a guanine nucleotide exchange factor for Rho proteins, affects vesicle trafficking
Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.
Keely et al., Madison, United States. In Mol Biol Cell, 2012
extracellular matrix stiffness regulates RhoA through microtubule destabilization and the subsequent release and activation of GEF-H1.
Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.
Marchetti et al., Houston, United States. In Mol Cancer Res, 2012
Data indicate that highly aggressive spindle-shaped 231BR3 cells changed to a round cell morphology associated with expression of the small GTPase guanine nucleotide exchange factor-H1 (GEF-H1).
Guanine-nucleotide exchange factor H1 mediates lipopolysaccharide-induced interleukin 6 and tumor necrosis factor α expression in endothelial cells via activation of nuclear factor κB.
Huan et al., Shanghai, China. In Shock, 2012
LPS rapidly upregulates GEF-H1 expression. Activated Rho-associated kinase by GEF-H1 subsequently activates p38 and ERK1/2, thereby increasing IL-6/TNF-alpha expression in endothelial cells.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Krause et al., New Haven, United States. In Dev Cell, 2012
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
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