gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GDP dissociation inhibitor 1

GDP dissociation inhibitor, GDI1, Rab GDP dissociation inhibitor, Rab-GDI, sec19
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, Rab5, CAN, fibrillin-1, RhoGDI
Papers on GDP dissociation inhibitor
Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.
Han et al., Beijing, China. In Oncotarget, Feb 2016
The RNA-binding proteinPCBP2, an oncogenic protein in human malignant gliomas, is an essential regulator of mRNA and miRNA biogenesis, stability and activity.Here, we identified Rho GDP dissociation inhibitor α (ARHGDIA) as a target mRNA that binds to PCBP2, and we uncovered the role of ARHGDIA as a putative metastasis suppressor through analyses of in vitro and in vivo models of EMT and metastasis.
Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.
Takano et al., In Small Gtpases, Feb 2016
Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GDIα), have been reported in patients with heritable NS and encode the following amino acid changes: ΔD185, R120X, and G173V.
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
Sherwood et al., Boston, United States. In Plos Genet, Jan 2016
We also characterized a novel invadopodia regulator, gdi-1 (Rab GDP dissociation inhibitor), which mediates membrane trafficking.
miR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1.
Pan et al., Quanzhou, China. In Oncotarget, Dec 2015
MiR-25 is activated by the WNT/β-catenin signaling pathway, and exerts its pro-metastatic function by directly inhibiting the Rho GDP dissociation inhibitor alpha (RhoGDI1).
eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach.
Wang et al., Chengdu, China. In Sci Rep, 2014
Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is involved in cell survival and proliferation, and Rho GDP dissociation inhibitor alpha (RhoGDIα), a member of Rho GDI family that is involved in cytoskeletal reorganization.
How not to do kinetics: examples involving GTPases and guanine nucleotide exchange factors.
Goody, Dortmund, Germany. In Febs J, 2014
In a final example, it is shown how the lack of an appropriate kinetic investigation led to the false conclusion that a secreted protein from Legionella pneumophila can act not only as a GEF towards eukaryotic Rab1 but also as a factor that is able to actively dissociate the stable complex between Rab1 and GDP dissociation inhibitor.
Possible involvement of GDI1 protein, a GDP dissociation inhibitor related to vesicle transport, in an amelioration of zinc toxicity in Saccharomyces cerevisiae.
Nakakihara et al., Okayama, Japan. In Yeast, 2012
GDI1 protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content.
Novel GDI1 mutation in a large family with nonsyndromic X-linked intellectual disability.
Tzschach et al., Ulm, Germany. In Am J Med Genet A, 2011
GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers.
Mutations in GDI1 and X-linked non-specific mental retardation.
Baggiani et al., Carrara, Italy. In Ann Ig, 2011
The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype.
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.
Pavitt et al., Manchester, United Kingdom. In Nature, 2010
First we show that eIF5 stabilizes the binding of GDP to eIF2 and is therefore a bi-functional protein that acts as a GDP dissociation inhibitor (GDI).
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.
Bonetto et al., Milano, Italy. In Mol Cell Proteomics, 2010
A model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway.
RhoGDI2 as a therapeutic target in cancer.
Yoo et al., Chinju, South Korea. In Expert Opin Ther Targets, 2010
IMPORTANCE OF THE FIELD: Rho GDP dissociation inhibitor 2 (RhoGDI2) has been identified as a regulator of Rho GTPases that play important roles in the development of numerous aspects of the malignant phenotype, including cell cycle progression, resistance to apoptotic stimuli, neovascularization, tumor cell motility, invasiveness, and metastasis.
Pathways of metastasis suppression in bladder cancer.
Theodorescu et al., Charlottesville, United States. In Cancer Metastasis Rev, 2009
We have recently identified Rho family GDP dissociation inhibitor 2 (RhoGDI2) protein as functional metastasis suppressor and a prognostic marker in patients after cystectomy.
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
Seabra et al., London, United Kingdom. In J Lipid Res, 2006
The REP-like protein Rab GDP dissociation inhibitor (RabGDI) then recycles the prenylated Rab between the membrane and the cytosol.
[Non-specific X-linked mental retardation].
Martínez-Castellano, Valencia, Spain. In Rev Neurol, 2006
Other types of functions of the known genes include establishing and modulating synapses (DLG3, IL1RAPL, NLGN4X, GDI1), regulating transcription (ZNF41, ZNF81, PQBP1) translation (FTSJ1), and fatty acid metabolism (FACL4), etc. CONCLUSIONS: Each gene that has been identified only accounts for a minor fraction of the total amount of XLMR, and even if taken together they still do not explain half the cases of non-specific XLMR.
A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells.
Dolan et al., Norwich, United Kingdom. In Nature, 2006
We cloned SCN1 and showed that SCN1 is a RhoGTPase GDP dissociation inhibitor (RhoGDI) that spatially restricts the sites of growth to a single point on the trichoblast.
Yip3 catalyses the dissociation of endosomal Rab-GDI complexes.
Pfeffer et al., Stanford, United States. In Nature, 2003
Prenyl Rab-GDI complexes contain all of the information necessary to direct Rab delivery onto distinct membrane compartments.
Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.
Gal et al., Hamburg, Germany. In Nat Genet, 2000
So far, seven X-chromosomal genes mutated in nonspecific mental retardation (MRX) have been identified: FMR2, GDI1, RPS6KA3, IL1RAPL, TM4SF2, OPHN1 and PAK3 (refs 2-9).
Mutations in GDI1 are responsible for X-linked non-specific mental retardation.
Toniolo et al., Pavia, Italy. In Nat Genet, 1998
We have found mutations in the GDI1 gene (which encodes uGDI) in two families affected with X-linked non-specific mental retardation.
share on facebooktweetadd +1mail to friends