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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glial cell derived neurotrophic factor

GDNF, Activating Transcription Factor 2, ATF-2, ATF
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: CAN, V1a, Brain-derived neurotrophic factor, AP-1, HAD
Papers using GDNF antibodies
Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid
Supplier
Yang Chuen-Mao et al., In Journal of Neuroinflammation, 2009
... PKCα and phospho-ATF2 antibodies were from Cell Signaling (Danver, MA) ...
A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
Supplier
Baek Seung Joon et al., In Oncogene, 2007
... Antibodies for PARP, phospho-JNK, JNK, phospho-p38MAPK, p38MAPK, and phospho-ATF2 (Thr71) were purchased from Cell Signaling (Beverly, MA) ...
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Supplier
Hartl Dominik, In PLoS ONE, 2006
... Antibodies for phospho-SAPK/JNK, total-SAPK/JNK, phospho-erk1/2, total-erk1/2, phospo-p38, phospho-c-jun, total-c-jun, phospho-ATF2, and IκBα were purchased from Cell Signaling Technologies (Beverly, MA) ...
Influence of diabetes on the loss of beta cell differenciation after islet transplantation in rats
Supplier
Dalle Stéphane et al., In Diabetes, 2006
... Anti–activating transcription factor (ATF)-1 and anti-glucokinase antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on GDNF
Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil.
New
Xiao et al., Datong, China. In Wound Repair Regen, Feb 2016
Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1β, IL-6 and TNF-⟨ were obviously inhibited, accompanied by the decrease of inflammatory M1 iNOS and the increase of anti-inflammatory M2 Arg-1, providing a microenvironment that contributes to synaptic protection.
A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2.
New
Kawashita et al., Cuiabá, Brazil. In Lipids, Feb 2016
Our results suggest that the increase in UCP1 content may occur via p38 MAPK and ATF2.
Recent progress in therapeutic strategy for ischemic stroke.
New
Abe et al., In Cell Transplant, Feb 2016
Secondly, we estimated the neuroprotective effect of glial cell line-derived neurotrophic factor (GDNF) by injecting sendai viral vector containing GDNF gene into post-ischemic brain.
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system.
New
González-Hernández et al., Santa Cruz de Tenerife, Spain. In Neurobiol Dis, Feb 2016
On the other hand, numerous studies support that the glial cell line-derived neurotrophic factor (GDNF) has a protective effect on DA-cells.
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease.
Review
New
Liss et al., Hamburg, Germany. In Febs Lett, Jan 2016
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system.
Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease.
Review
New
Saarma et al., Helsinki, Finland. In Febs Lett, Jan 2016
Glial cell line-derived neurotrophic factor (GDNF) and related neurturin (NRTN) can protect and repair DA neurons in neurotoxin animal models of PD.
Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease.
New
Yeh et al., Taiwan. In Sci Rep, Dec 2015
Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons.
Current disease modifying approaches to treat Parkinson's disease.
Review
New
Saarma et al., Helsinki, Finland. In Cell Mol Life Sci, Dec 2015
In particular, studies employing glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NRTN), as well as the recently described cerebral dopamine neurotrophic factor (CDNF) and the mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown positive results in protecting and repairing dopaminergic neurons in various models of PD.
Purine nucleosides in neuroregeneration and neuroprotection.
Review
New
Sebastião et al., Lisbon, Portugal. In Neuropharmacology, Dec 2015
brain derived neurotrophic factor (BDNF), glial derived neurotrophic factor (GDNF), is also focused considering the intimate relationship between some adenosine receptors, as is the case of the A2A receptors, and receptors for neurotrophins.
GDNF-induced cerebellar toxicity: A brief review.
Review
New
Fibiger et al., Canada. In Neurotoxicology, Dec 2015
UNASSIGNED: Recombinant-methionyl human glial cell line-derived neurotrophic factor (GDNF) is known for its neurorestorative and neuroprotective effects in rodent and primate models of Parkinson's disease (PD).
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.
Impact
Simmons et al., Oxford, United Kingdom. In Immunity, 2013
In particular, miR-29 downregulated interleukin-23 (IL-23) by targeting IL-12p40 directly and IL-23p19 indirectly, likely via reduction of ATF2.
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks.
Review
Impact
Murphy et al., Saint Louis, United States. In Nat Rev Immunol, 2013
Basic leucine zipper transcription factor ATF-like (BATF), BATF2 and BATF3 belong to the activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular processes.
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
Impact
Zender et al., Hannover, Germany. In Cell, 2013
Mechanistically, induction of MKK7 and a JNK1-dependent activation of the AP1 transcription factor ATF2 and the Ets factor ELK1 are crucial for increased regeneration of hepatocytes with MKK4 silencing.
Reconstitution of mouse spermatogonial stem cell niches in culture.
Impact
Shinohara et al., Kyoto, Japan. In Cell Stem Cell, 2012
Cobblestone colony formation depended on GDNF and CXCL12, and dominant-negative GDNF receptor transfection or CXCL12 receptor deficiency reduced SSC colonization.
GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization.
GeneRIF
Ubogu et al., Houston, United States. In Microvasc Res, 2012
GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.
Impact
Wahlestedt et al., Miami, United States. In Nat Biotechnol, 2012
We also show that inhibition of NATs leads to increases in glial-derived neurotrophic factor (GDNF) and ephrin receptor B2 (EPHB2) mRNA.
Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun).
GeneRIF
LoGrasso et al., Jupiter, United States. In J Biol Chem, 2012
we report the kinetic mechanism for JNK1beta1 with transcription factors ATF2 and c-Jun along with interaction kinetics for these substrates.
Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.
GeneRIF
Hu et al., West Lafayette, United States. In J Biol Chem, 2012
ATF2 subcellular localization is probably modulated by multiple mechanisms
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
Impact
GeneRIF
Ronai et al., Los Angeles, United States. In Cell, 2012
The ability of ATF2 to reach the mitochondria is determined by PKCepsilon, which directs ATF2 nuclear localization. Genotoxic stress attenuates PKCepsilon effect on ATF2; enables ATF2 nuclear export and localization at the mitochondria.
GDNF protects enteric glia from apoptosis: evidence for an autocrine loop.
GeneRIF
von Boyen et al., Marburg an der Lahn, Germany. In Bmc Gastroenterol, 2011
There is an autocrine anti-apoptotic loop in enteric glia cells which is operative in Crohn's disease and dependent of GDNF.
More papers using GDNF antibodies
Characterization of ST13 Protein Expression in Human Colorectal Cancer Tissues
Supplier
Han Zhaozhong, In PLoS ONE, 2004
... Antibodies against caspase-3, caspase-9, Fas, Bcl-XL, CHOP, E1A, p38, Phospho-p38 MAP Kinase, ATF-2 and Phospho-ATF-2 were purchased from Cell Signaling Technology, Inc ...
Prostaglandin E2 enhances pancreatic cancer invasiveness through an ETS1-dependent induction of matrix metalloproteinase-2
Supplier
Fang Deyu et al., In Arthritis Research & Therapy, 2003
... Antibodies against Erk, c-Jun, and ATF2, as well as their phosphorylated forms, were purchased from Promega Corporation.
Postnatal development of 5-HT(1A) receptor expression in rat somatic motoneurons.
Supplier
Linden Rafael, In PLoS ONE, 1999
... Generation of ATF2 mutant transgenic mice ...
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord
Supplier
Wang Ting-Hua et al., In Neurochemical Research, 1998
... To localize GDNF protein in the spinal cord, an affinity-purified rabbit polyclonal antibody (D-20, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
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