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Growth differentiation factor 9

GDF9, growth differentiation factor 9
Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMP15, glycodelin, FSH, HAD, CAN
Papers on GDF9
Quantitative expression patterns of GDF9 and BMP15 genes in sheep ovarian follicles grown in vivo or cultured in vitro.
New
Rao et al., Tirupati, India. In Theriogenology, Feb 2016
Quantitative patterns of expression of the growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15) genes in different development stages of in vivo and in vitro grown ovarian follicles in sheep were studied for the first time.
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
New
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
Fifty-one gene elements were overdetected on the 8C arrays relative to hES/iPS cells, including 14 detected at least 80-fold higher, which annotated to multiple pathways: six cytokine family (CSF1R, IL2RG, IL3RA, IL4, IL17B, IL23R), four transforming growth factor beta (TGFB) family (BMP6, BMP15, GDF9, ENG), one fibroblast growth factor (FGF) family [FGF14(FH4)], one epidermal growth factor member (GAB1), plus CD36, and CLEC10A.
Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.
New
Seli et al., New Haven, United States. In Endocrinology, Jan 2016
The abnormalities in Epab(-/-) CCs are not due to lower expression of the oocyte-derived factors growth differentiation factor 9 or bone morphogenetic protein 15, because Epab(-/-) oocytes express these proteins at comparable levels with WT.
Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
New
García-Velasco et al., Madrid, Spain. In Eur J Obstet Gynecol Reprod Biol, Jan 2016
Main outcome measures were growth-differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15) expression, hormonal profile and apoptosis rate.
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
New
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
qPCR analysis revealed that BMP4 at a concentration of 50-100 ngml(-1) for a culture period of 14 days led to maximum induction of germ lineage genes like DAZL, VASA, PLZF (PGC-specific); SYCP3, MLH1, TNP1/2 and PRM2 (Meiotic genes); BOULE and TEKT1 (Spermatocyte markers); GDF9, ZP2 and 3 (Oocyte markers).
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
New
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Quantitative polymerase chain reaction analysis revealed that 20%-40% CCM induced the highest expression of primordial germ cell-specific (deleted in Azoospermia- like (Dazl), dead (Asp-Glu-Ala-Asp) box polypeptide 4 (Vasa also known as DDX4) and promyelocytic leukemia zinc finger protein (Plzf)); meiotic (synaptonemal complex protein 3 (Sycp3), mutl homolog I (Mlh1), transition protein 1/2 (Tnp1/2) and protamine 2 (Prm2); spermatocyte-specific boule-like RNA binding protein (Boule) and tektin 1 (Tekt1)) and oocyte-specific growth differentiation factor 9 (Gdf9) and zona pellucida 2 /3 (Zp2/3)) genes over 8-14 days in culture.
Genetics of primary ovarian insufficiency: new developments and opportunities.
Review
New
Chen et al., Jinan, China. In Hum Reprod Update, Nov 2015
Based on candidate gene studies, single gene perturbations unequivocally having a deleterious effect in at least one population include Bone morphogenetic protein 15 (BMP15), Progesterone receptor membrane component 1 (PGRMC1), and Fragile X mental retardation 1 (FMR1) premutation on the X chromosome; Growth differentiation factor 9 (GDF9), Folliculogenesis specific bHLH transcription factor (FIGLA), Newborn ovary homeobox gene (NOBOX), Nuclear receptor subfamily 5, group A, member 1 (NR5A1) and Nanos homolog 3 (NANOS3) seem likely as well, but mostly being found in no more than 1-2% of a single population studied.
Influence of BMP-2 on early follicular development and mRNA expression of oocyte specific genes in bovine preantral follicles cultured in vitro.
New
Silva et al., Sobral, Brazil. In Histol Histopathol, Nov 2015
It also investigates the effects of FSH and BMP-2 on the growth, morphology, ultrastructure and expression of mRNA for GDF9, NLRP5 and NPM2 genes in secondary follicles cultured for 18 days.
The domestic chicken: Causes and consequences of an egg a day.
Review
New
Giles et al., Ithaca, United States. In Poult Sci, Apr 2015
Recent findings in mammals have indicated that the oocyte produces several oocyte-specific factors, including growth differentiation factor 9 (GDF9) and bone morphogenetic factor 15 (BMP15), which influence the surrounding cells and follicular development.
Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
Xu et al., Changchun, China. In Plos One, 2014
In this study, the cooperative effects of FOXL2 with activin A, growth differentiation factor-9 (GDF9) and follistatin, three members of the transforming growth factor beta (TGF-β) superfamily that were previously suggested to exert a critical role in follicle development was investigated.
The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders.
Review
Fabre et al., Milano, Italy. In Hum Reprod Update, 2014
METHODS: A thorough literature search was carried out in order to summarize what has been reported so far on the role of BMP15, and the BMP15 paralog, growth and differentiation factor 9 (GDF9), in ovarian function and female fertility.
Cell reprogramming. Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming.
Impact
Cibelli et al., Spain. In Science, 2014
We also show that overexpression of just ASF1A and OCT4 in hADFs exposed to the oocyte-specific paracrine growth factor GDF9 can reprogram hADFs into pluripotent cells.
Genetic associations with diminished ovarian reserve: a systematic review of the literature.
Review
Segars et al., New York City, United States. In J Assist Reprod Genet, 2014
RESULTS: Twenty-one articles identified genes associated with DOR: one gene mutation (FMR1), three polymorphisms (GDF9, FSHR, and ESR1), and seven genes differentially expressed between women with DOR and controls (AMH, LHCGR, IGF1, IGF2, IGF1R, IGF2R and GREM1).
Role of oocyte-derived paracrine factors in follicular development.
Review
Sugiura et al., Tokyo, Japan. In Anim Sci J, 2014
Mammalian oocytes secrete transforming growth factor β (TGF-β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs).
Inhibition of follicular development induced by chronic unpredictable stress is associated with growth and differentiation factor 9 and gonadotropin in mice.
GeneRIF
Zhou et al., Hefei, China. In Biol Reprod, 2012
The results show that chronic unpredictable stress suppresses GDF9 expression.
Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
GeneRIF
Gilchrist et al., Adelaide, Australia. In Mol Hum Reprod, 2012
show that purified mature regions of GDF9 and BMP15 synergistically interact in a specific manner which is not dependent on the presence of a pro-region.
Growth differentiation factor-9 expression is inversely correlated with an aggressive behaviour in human bladder cancer cells.
GeneRIF
Jiang et al., Cardiff, United Kingdom. In Int J Mol Med, 2012
GDF-9 levels are inversely correlated with the growth, adhesion and migration of bladder cancer cells in vitro.
Activation of latent human GDF9 by a single residue change (Gly 391 Arg) in the mature domain.
GeneRIF
Harrison et al., Australia. In Endocrinology, 2012
GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals
Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells.
GeneRIF
Leung et al., Vancouver, Canada. In Plos One, 2010
GDF9 decreases basal and activin A-induced FST and FSTL3 expression, and this explains, in part, its enhancing effects on activin A-induced inhibin beta(B)-subunit mRNA expression and inhibin B production in hGL cells
Growth differentiation factor-9 is required during early ovarian folliculogenesis.
Impact
Matzuk et al., Houston, United States. In Nature, 1996
During the functional analysis of members of the transforming growth factor-beta superfamily in mouse development, we have uncovered a new family member, growth differentiation factor-9 (GDF-9), which is required for ovarian folliculogenesis.
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