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Growth differentiation factor 7

GDF7, BMP-12
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: glycodelin, GDF6, CAN, SBS, GDF5
Papers on GDF7
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Schumacher et al., Bonn, Germany. In Cancer Med, Feb 2016
In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence.
Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
Thomopoulos et al., Atlanta, United States. In J Orthop Res, Nov 2015
UNASSIGNED: The outcomes of flexor tendon repair are highly variable.
Multidifferentiation potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy.
de Girolamo et al., Milano, Italy. In Regen Med, Sep 2015
The tenogenic induction with BMP-12 upregulated SCX and DCN gene expression in both populations.
Ll et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, Apr 2015
OBJECTIVE: To research the effect of recombinant adenovirus-bone morphogenetic protein 12 (Ad-BMP-12) transfection on the differentiation of peripheral blood mesenchymal stem cells (MSCs) into tendon/ligament cells.
Effects of BMP-12-releasing sutures on Achilles tendon healing.
Murphy et al., Madison, United States. In Tissue Eng Part A, Mar 2015
Additionally, previous reports indicated that treatment with bone morphogenetic protein-12 (BMP-12) improved tendon healing.
Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Jankowski et al., Rotterdam, Netherlands. In Gastroenterology, Feb 2015
The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development.
Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.
Asahara et al., Tokyo, Japan. In J Orthop Res, 2015
Human BMMSCs were treated with 50 ng/ml BMP-12 or transduced with MKX or scleraxis (SCX) adenoviral vector.
The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation.
Sun et al., New York City, United States. In Sci Rep, 2014
We also reveal that mechanical loading-mediated tenocytic differentiation follows a similar pathway and that BMP-12 and cyclic uniaxial strain act in an additive fashion to augment the maximal response by activating signal transducer Smad8.
CTGF positively regulates BMP12 induced tenogenic differentiation of tendon stem cells and signaling.
Tang et al., Chongqing, China. In Cell Physiol Biochem, 2014
The aim of our study was to determine if CTGF exerts a similar effect on BMP12-driven differentiation of rat TSCs.
EGR1 induces tenogenic differentiation of tendon stem cells and promotes rabbit rotator cuff repair.
Tang et al., Chongqing, China. In Cell Physiol Biochem, 2014
The BMP12/Smad1/5/8 signaling pathway was involved in EGR1-induced tenogenic differentiation and rotator cuff tendon repair.
Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12.
Zhou et al., Beijing, China. In J Transl Med, 2014
This study aimed to compare the different tenogenic differentiation capacities of the three types of MSCs in the presence of bone morphogenic protein 12 (BMP-12).
Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair.
Seeherman et al., Cambridge, United States. In J Orthop Res, 2011
expression regulated during tendon healing
Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.
Jelinsky et al., Cambridge, United States. In Growth Factors, 2011
studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.
Steinert et al., Würzburg, Germany. In Cytotherapy, 2010
induces ligamentogenic differentiation in mesenchymal progenitors
Effects of cartilage-derived morphogenetic protein-3 on the expression of chondrogenic and osteoblastic markers in the pluripotent mesenchymal C3H10T1/2 cell line.
Lee et al., San Antonio, United States. In Growth Factors, 2010
stimulates expression of both chondrogenic and osteoblstic markers in pluripotent mesenchymal C3H10T1/2 cells.
Effect of GDF-7 deficiency on tail tendon phenotype in mice.
Bierwert et al., Northampton, United States. In J Orthop Res, 2008
compensation by Gdf-5 may be at least in part responsible for the absence of a strong phenotype in GDF-7 deficient mice
Biological augmentation of rotator cuff tendon repair.
Rodeo et al., New York City, United States. In Clin Orthop Relat Res, 2008
We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing.
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands.
Hsueh et al., Stanford, United States. In Hum Reprod Update, 2006
Furthermore, we demonstrated the roles of BMPRII, ALK3 and ALK6 as the receptors for the orphan ligands GDF6, GDF7 and BMP10.
Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment.
Wozney et al., Philadelphia, United States. In J Clin Periodontol, 2004
Subcutaneous and intramuscular implants of BMP-12 have been shown to induce tendon formation and ligament-like tissue.
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.
Lee et al., Stanford, United States. In Nature, 1994
GDF5 and the closely related GDF6 and GDF7 define a new subgroup of factors related to known bone- and cartilage-inducing molecules, the bone morphogenetic proteins (BMPs).
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