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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Growth differentiation factor 5

GDF5, CDMP-1, growth differentiation factor-5, cartilage-derived morphogenetic protein-1
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using GDF5 antibodies
Papers on GDF5
Genetic contribution to radiographic severity in osteoarthritis of the knee.
Doherty et al., London, United Kingdom. In Ann Rheum Dis, 2012
In conclusion, we find that GDF5, but not COG5 or MCF2L, influence the extent of radiographic damage in knee osteoarthritis
New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.
Knaus et al., Berlin, Germany. In J Bone Miner Res, 2012
A novel molecular mechanism of a GDF5 mutation affecting chondrogenesis and osteogenesis, is reported.
Delayed fracture healing in growth differentiation factor 5-deficient mice: a pilot study.
Tuan et al., Bethesda, United States. In Clin Orthop Relat Res, 2011
Although GDF-5 deficiency did not compromise long-term fracture healing, a delay in cartilage formation and remodeling supports roles for GDF-5 in the early phase of bone repair.
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.
Loughlin et al., Newcastle upon Tyne, United Kingdom. In Hum Mol Genet, 2011
Data demonstrates that the genetic effect of the rs143383 SNP on GDF5 expression is modulated epigenetically by DNA methylation.
A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population.
Wajanavisit et al., Bangkok, Thailand. In J Orthop Surg Res, 2010
GDF5 polymorphism has an association with knee osteoarthritis in Thai ethnic.
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