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Growth differentiation factor 3

GDF3, Growth Differentiation Factor 3
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Nanog, Sox2, TGF-beta, glycodelin
Papers on GDF3
PEGylated Carbon Nanocapsule: A Universal Reactor and Carrier for In Vivo Delivery of Hydrophobic and Hydrophilic Nanoparticles.
Sivakumar et al., Kānpur, India. In Acs Appl Mater Interfaces, Feb 2016
Stable and inert nature of carbon capsules in a wide range of reaction conditions like high temperature and harsh solvents, make it suitable for being used as nano/microreactors for the syntheses of a variety of NPs for bioimaging applications, such as NaYF4:Eu(3+)(5%), LaVO4:Eu(3+)(10%), GdVO4:Eu(3+)(10%), Y2O3:Eu(3+)(5%), GdF3:Tb(3+)(10%), Mo, Pt, Pd, Au, and Ag.
Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia.
UK10K Consortium et al., London, United Kingdom. In Ann Hum Genet, Jan 2016
X-ray excited photoluminescence near the giant resonance in solid-solution Gd1-xTbxOCl nanocrystals and their retention upon solvothermal topotactic transformation to Gd1-xTbxF3.
Banerjee et al., College Station, United States. In Nanoscale, Jan 2016
The metastable hexagonal phase of GdF3 can be stabilized at room temperature through this topotactic approach and is transformed subsequently to the orthorhombic phase.
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
Niakan et al., Farmington, United States. In Development, Oct 2015
For example, we identify several genes exclusively expressed in the human pluripotent epiblast, including the transcription factor KLF17. Key components of the TGF-β signalling pathway, including NODAL, GDF3, TGFBR1/ALK5, LEFTY1, SMAD2, SMAD4 and TDGF1, are also enriched in the human epiblast.
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.
Luo et al., Århus, Denmark. In Stem Cell Res Ther, 2014
The iPSC-MSCs and the tri-lineage differentiated cells (osteoblasts, chondrocytes, adipocytes) all lack expression of "stemness" genes: OCT4, SOX2, GDF3, CRIPTO, UTF1, DPPA4, DNMT3B, LIN28a, and SAL4.
Synthesis, characterization, and cytotoxicity in human erythrocytes of multifunctional, magnetic, and luminescent nanocrystalline rare earth fluorides.
Lis et al., Poznań, Poland. In J Nanopart Res, 2014
The hydrothermal method was used for the synthesis of Eu(3+)- or Tb(3+)-doped GdF3-, NaGdF4-, and BaGdF5-based nanocrystalline materials.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.
Reviewing and updating the major molecular markers for stem cells.
Bonatto et al., Porto Alegre, Brazil. In Stem Cells Dev, 2013
The commonly cited markers for embryonic ESCs are Nanog, Oct-4, Sox-2, Rex-1, Dnmt3b, Lin-28, Tdgf1, FoxD3, Tert, Utf-1, Gal, Cx43, Gdf3, Gtcm1, Terf1, Terf2, Lefty A, and Lefty B. MSCs are primarily identified by the expression of CD13, CD29, CD44, CD49e, CD54, CD71, CD73, CD90, CD105, CD106, CD166, and HLA-ABC and lack CD14, CD31, CD34, CD45, CD62E, CD62L, CD62P, and HLA-DR expression.
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.
Vale et al., Los Angeles, United States. In Febs Lett, 2012
Cripto functions as an obligatory co-receptor for the TGF-β ligands Nodal, GDF1 and GDF3 but attenuates signaling of others such as activin-A, activin-B and TGF-β1.
GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.
Yu et al., Shanghai, China. In J Cancer Res Clin Oncol, 2012
GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues.
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
Taketani et al., Tokyo, Japan. In Fertil Steril, 2012
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
Yu et al., Shanghai, China. In Mol Cell Biochem, 2012
the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.
Blencowe et al., Toronto, Canada. In Cell, 2011
We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation.
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Brown et al., Houston, United States. In Endocr Rev, 2011
BMP7, growth differentiation factor (GDF) 8, and GDF3 are versatile in their mechanisms of action, and altering their normal expression characteristics has significant effects on adiposity in vivo.
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.
Lehmann et al., Edmonton, Canada. In Hum Mol Genet, 2010
Mutation of GDF3 causes ocular and skeletal anomalies.
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma.
Seya et al., Sapporo, Japan. In J Exp Clin Cancer Res, 2009
GDF3 has the ability to induce progression of CD24-inducible melanoma in mice.
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
Schlaeger et al., Boston, United States. In Nat Biotechnol, 2009
Proviral silencing and expression of TRA-1-60, DNMT3B and REX1 can be used to distinguish the fully reprogrammed state, whereas alkaline phosphatase, SSEA-4, GDF3, hTERT and NANOG are insufficient as markers.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Zhang et al., United Kingdom. In Nat Biotechnol, 2007
They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3.
GDF3 at the crossroads of TGF-beta signaling.
Brivanlou et al., New York City, United States. In Cell Cycle, 2006
This review will summarize the current understanding of TGF-beta signaling in ES and focus on early embryological roles of the TGF-beta member, GDF-3.
Visible quantum cutting in GdF3:Eu(3+) nanocrystals via downconversion.
Li et al., Dalian, China. In Nanotechnology, 2006
GdF3:Eu(3+) nanocrystals (NCs) and nanorods were synthesized by a microemulsion-mediated hydrothermal process.
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