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Growth differentiation factor 3

GDF3, Growth Differentiation Factor 3
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on GDF3
GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.
GeneRIF
Yu et al., Shanghai, China. In J Cancer Res Clin Oncol, 2012
GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues.
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
GeneRIF
Taketani et al., Tokyo, Japan. In Fertil Steril, 2012
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
GeneRIF
Yu et al., Shanghai, China. In Mol Cell Biochem, 2012
the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.
GeneRIF
Lehmann et al., Edmonton, Canada. In Hum Mol Genet, 2010
Mutation of GDF3 causes ocular and skeletal anomalies.
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma.
GeneRIF
Seya et al., Sapporo, Japan. In J Exp Clin Cancer Res, 2009
GDF3 has the ability to induce progression of CD24-inducible melanoma in mice.
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