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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth differentiation factor 11

GDF11, growth differentiation factor 11, BMP-11
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: myostatin, CAN, SFRP1, AGE, TGF-beta
Papers on GDF11
Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategies.
New
Courtois et al., Paris, France. In Curr Opin Hematol, Feb 2016
SUMMARY: Growth differentiation factor 11 (GDF11) blockade increases the apoptosis of erythroblasts with excess α-chains by upregulating Fas-ligand in late basophilic and polychromatophilic erythroblasts, thereby decreasing cell expansion (step 1).
Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span.
New
Pazdro et al., Athens, United States. In J Gerontol A Biol Sci Med Sci, Feb 2016
UNASSIGNED: Growth differentiation factor 11 (GDF11) is member of the transforming growth factor β (TGF-β) superfamily of proteins.
Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.
New
Melzer et al., Exeter, United Kingdom. In Physiol Genomics, Jan 2016
Blood-borne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models.
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency.
New
Hyun et al., Ch'unch'ŏn, South Korea. In Can J Vet Res, Jan 2016
Abstract available from the publisher.
Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease.
Review
New
Lüscher et al., Zürich, Switzerland. In Eur Heart J, Jan 2016
GDF11, a member of TGFβ superfamily with homology to myostatin also retards the aging process via yet unknown mechanisms.
Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration.
Review
New
Vergely et al., Dijon, France. In Pharmacol Ther, Dec 2015
Growth and differentiation factor 11 (Gdf11) as activins belong to the TGF-β family.
Circulating Growth Differentiation Factor 11/8 Levels Decline with Age.
New
Lee et al., Cincinnati, United States. In Circ Res, Nov 2015
RATIONALE: Growth differentiation factor 11 (GDF11) and 8 (GDF8) are members of the TGF-β superfamily sharing 89% protein sequence homology.
Blood-Borne Revitalization of the Aged Brain.
Review
New
Wyss-Coray et al., Palo Alto, United States. In Jama Neurol, Oct 2015
The age-associated plasma chemokine CCL11 has been shown to impair young brain function while GDF11 has been reported to increase the generation of neurons in aged mice.
GDF11 and the Mythical Fountain of Youth.
New
Impact
Rudnicki et al., Ottawa, Canada. In Cell Metab, Aug 2015
(2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
New
Impact
Glass et al., Cambridge, United States. In Cell Metab, Aug 2015
The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear.
The aging human recipient of transfusion products.
Review
New
Risch et al., Bern, Switzerland. In Transfus Apher Sci, Jun 2015
Components of blood plasma, such as the growth-differentiation protein GDF11, were shown to enhance neurogenesis and to improve the vasculature in the animal cortex and to rejuvenate muscle tissue.
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function.
Review
Cotta-de-Almeida et al., Rio de Janeiro, Brazil. In Front Immunol, 2014
Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.
Rejuvenation: it's in our blood.
Impact
Kaeberlein et al., Seattle, United States. In Cell Metab, 2014
Recent studies report that rejuvenating effects of young blood extend to multiple tissues and have identified GDF11 and CCL11 as factors mediating these effects.
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Impact
Wagers et al., Cambridge, United States. In Science, 2014
Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle.
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.
Impact
Rubin et al., Cambridge, United States. In Science, 2014
Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis.
Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone formation.
GeneRIF
Yang et al., Honolulu, United States. In Biochem Biophys Res Commun, 2012
These results suggest that over-expression of BMP11 propeptide stimulates bone formation by increasing osteoblast cell functions.
Restoration of retinal development in Vsx2 deficient mice by reduction of Gdf11 levels.
GeneRIF
Calof et al., Irvine, United States. In Adv Exp Med Biol, 2011
Reducing GDF11 levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.
Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.
GeneRIF
Calof et al., Irvine, United States. In Development, 2011
the transition between stem cells and committed progenitors is neither sharp nor irreversible and GDF11, ACTbetaB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in this system
PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations.
GeneRIF
Kubota et al., Kyoto, Japan. In Eur J Pediatr Surg, 2011
PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.
Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord.
GeneRIF
Liu et al., Charlottesville, United States. In J Neurosci, 2011
Gdf11 secreted by newly born neurons in the developing spinal cord facilitates the temporal progression of neurogenesis by acting as a positive feedback signal on the progenitor cells to promote cell cycle exit and decrease proliferation ability.
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