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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Growth differentiation factor 1

GDF1, growth differentiation factor
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes the LAG1 homolog, ceramide synthase 1 gene. [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: glycodelin, GDF9, CAN, HAD, BMP15
Papers on GDF1
Comparison of Inflammatory Biomarkers in Outpatients With Prior Myocardial Infarction.
New
Ikeda et al., Chinju, South Korea. In Int Heart J, Feb 2016
We enrolled 430 post-MI patients and measured their levels of high-sensitivity C reactive protein (hs-CRP), growth differentiation factor-15 (GDF-15), and the interleukin-1 receptor family member called ST2 (ST2), one month after AMI.
Elevated growth differentiation factor 15 expression predicts poor prognosis in epithelial ovarian cancer patients.
New
Wang et al., Xi'an, China. In Tumour Biol, Feb 2016
UNASSIGNED: The purpose of this study was to determine the expression of growth differentiation factor 15 (GDF15) and explore its clinical significance in epithelial ovarian cancer (EOC) patients.
Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.
Review
New
Shin et al., Atlanta, United States. In Semin Cancer Biol, Dec 2015
Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways.
Beyond Cholesterol - New Cardiovascular Biomarkers.
New
Mangge, In Nestle Nutr Inst Workshop Ser, Dec 2015
troponin, copetin, natriuretic peptides, growth differentiation factor-15, or soluble ST2) indicate the acute coronary syndrome or cardiac insufficiency, but not a critical destabilization of AS lesions in coronary or carotid arteries.
Inflammatory biomarkers predicting prognosis in patients with acute dyspnea.
New
Melander et al., Lund, Sweden. In Am J Emerg Med, Dec 2015
(P = 2.5 × 10(-8)) and for growth differentiation factor-15 (GDF-15) was 3.45 (2.18-5.45)
Hepcidin/Ferritin Quotient Helps to Predict Spontaneous Recovery from Iron Loss following Blood Donation.
New
Schrezenmeier et al., Ulm, Germany. In Transfus Med Hemother, Nov 2015
Prospectively, we tested 27 male repeat donors for the following parameters at the day of blood donation as well as 1, 3, 7, 10, and 56 days thereafter: ferritin, hepcidin, transferrin, transferrin receptor, hemoglobin, erythropoietin, reticulocytes, hemoglobin in reticulocyte, twisted gastrulation protein homolog 1, and growth differentiation factor-15.
Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions.
Review
New
Pankhurst et al., Dunedin, New Zealand. In J Endocrinol, Sep 2015
AMH shares an intracellular pathway with the bone morphogenetic protein (BMP) and growth differentiation factor (GDF) ligands.
The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies.
Review
New
Çiftçioğlu et al., Antalya, Turkey. In Arch Dermatol Res, Sep 2015
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily.
Can biomarkers help to diagnose early heart failure with preserved ejection fraction?
Review
Tomandl et al., Brno, Czech Republic. In Dis Markers, 2014
Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged.
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Impact
Wagers et al., Cambridge, United States. In Science, 2014
Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle.
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.
Impact
Moura et al., Paris, France. In Nat Med, 2014
Expression of growth differentiation factor 11 (GDF11), an ActRIIA ligand, was increased in splenic erythroblasts from thalassemic mice and in erythroblasts and sera from subjects with β-thalassemia.
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Impact
Kumar et al., Cambridge, United States. In Nat Med, 2014
ACE-536 bound growth differentiation factor-11 (GDF11) and potently inhibited GDF11-mediated Smad2/3 signaling.
Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat.
Review
Fiems, Belgium. In Animals (basel), 2011
Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily.
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Review
Impact
Brown et al., Houston, United States. In Endocr Rev, 2011
BMP7, growth differentiation factor (GDF) 8, and GDF3 are versatile in their mechanisms of action, and altering their normal expression characteristics has significant effects on adiposity in vivo.
Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).
GeneRIF
Lehtonen et al., Helsinki, Finland. In Hum Mol Genet, 2010
Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1.
Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma.
GeneRIF
Hu et al., Chengdu, China. In Gynecol Oncol, 2009
GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy.
Long-range action of Nodal requires interaction with GDF1.
GeneRIF
Saijoh et al., Suita, Japan. In Genes Dev, 2008
GDF1 regulates the activity and signaling range of Nodal through direct interaction
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
GeneRIF
Ibáñez et al., Stockholm, Sweden. In Dev Biol, 2007
Results suggest that GDF1 and GDF3 together represent the functional mammalian homologs of Vg1.
Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.
GeneRIF
Muenke et al., Bethesda, United States. In Am J Hum Genet, 2007
Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries.
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
Impact
Ikegawa et al., Tokyo, Japan. In Nat Genet, 2007
Here, we report that the gene encoding growth differentiation factor 5 (GDF5) is associated with osteoarthritis in Asian populations.
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